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Peer-reviewade publikationer — 56229 artiklar

Autoguided Online Data Curation for Diffusion Model Training
arXiv:2509.15267v2 Announce Type: replace Abstract: The costs of generative model compute rekindled promises and hopes for efficient data curation. In this work, we investigate whether recently developed autoguidance and online data selection methods can improve the time and sample efficiency of training generative diffusion models. We integrate joint example selection (JEST) and autoguidance into a unified code base for fast ablation and benchmarking. We evaluate combinations of data curation on a controlled 2-D synthetic data generation task as well as (3x64x64)-D image generation. Our comparisons are made at equal wall-clock time and equal number of samples, explicitly accounting for the overhead of selection. Across experiments, autoguidance consistently improves sample quality and diversity. Early AJEST (applying selection only at the beginning of training) can match or modestly exceed autoguidance alone in data efficiency on both tasks. However, its time overhead and added complexity make autoguidance or uniform random data selection preferable in most situations. These findings suggest that while targeted online selection can yield efficiency gains in early training, robust sample quality improvements are primarily driven by autoguidance. We discuss limitations and scope, and outline when data selection may be beneficial.
GRASP: Learning to Ground Social Reasoning in Multi-Person Non-Verbal Interactions
arXiv:2605.15764v1 Announce Type: new Abstract: Understanding social interactions requires reasoning over subtle non-verbal cues, yet current multimodal large language models (MLLMs) often fail to identify who interacts with whom in multi-person videos. We introduce GRASP, a large-scale social reasoning dataset that connects high-level social QA with fine-grained gaze and deictic gesture events. GRASP contains 290K question--answer pairs over 46K videos totaling 749 hours, organized by a 16-category taxonomy spanning gaze, gesture, and joint gaze--gesture reasoning, together with GRASP-Bench for evaluation. Unlike prior resources that focus on either isolated cues or high-level social QA, GRASP builds questions from identity-consistent gaze trajectories, deictic gestures, and their joint compositions into social events. Moreover, we propose Social Grounding Reward (SGR), a learning signal that uses these social events to encourage models to reason about the participants involved in each interaction. Experiments show that SGR improves performance on GRASP-Bench while maintaining zero-shot performance on related social video QA benchmarks.
Accelerating Zeroth-Order Spectral Optimization with Partial Orthogonalization from Power Iteration
arXiv:2605.09034v2 Announce Type: replace Abstract: Zeroth-order (ZO) optimization has become increasingly popular and important in fine-tuning large language models (LLMs), especially on edge devices due to its ability to adjust the model to local data without the need for memory-intensive back-propagation. Recent works try to reduce ZO variance through low-dimensional subspace search, but subspace restriction alone leaves key optimization geometry under-exploited, motivating additional acceleration. In this work, we focus on the hidden layer training problem in which spectral optimizers like Muon outperform AdamW due to its ability to exploit weak spectral directions by orthogonalization. However, we have discovered that unlike in the first-order setting, full orthogonalization works poorly in the ZO setting since the gradient estimates are highly noisy and unreliable. To address this issue, we propose applying partial spectral orthogonalization to accelerate ZO optimization. To do so, we replace the iconic Newton-Schulz procedure in Muon with the faster, more concentrated power-iteration method so that it only amplifies dominant spectral directions. Furthermore, to improve the efficiency and generalization of the algorithm, we adopted a streaming variant of power-iteration that requires low variance in gradients, which was achieved through constraining our search inside a subspace obtained through the projection of momentum, echoing recent advances. Experiments on LLM fine-tuning show that our method can achieve from 1.5x to 4x the convergence speed of ZO-Muon, the current SOTA algorithm, across SuperGlue datasets in the OPT-13B model. Across different models, we also reach competitive final accuracies with less time in most cases compared with strong ZO baselines such as MeZO, LOZO and ZO-Muon. Code is available at https://github.com/MOFA-LAB/ZO-MOPI.git.
Optimizing Chilled Water Systems with Cooling Towers via Virtual Power Metrics and Extremum-Seeking Control
arXiv:2605.15431v1 Announce Type: new Abstract: This paper presents an extremum seeking control (ESC) method for cooling tower fans to minimize overall power consumption of a chilled water plant system. Simulation studies across different climate locations demonstrate energy savings of approximately 15% compared to conventional control during summer conditions. This paper also proposes a virtual power meter (VPM) to enable use of the strategy in systems that lack physical power meters. Validation tests for the VPMs against physical meters showed good accuracy with a correlation of 96.11% and a normalized error of 5.11%. Coupled with the VPM, the proposed ESC control solution can be implemented on systems using typically available sensor measurements without the need for additional instrumentation.
A Unified View of Score-Based and Drifting Models
arXiv:2603.07514v3 Announce Type: replace Abstract: Drifting models train one-step generators by optimizing a kernel-induced mean-shift discrepancy between the data and model distributions, with Laplace kernels used by default in practice. At each point, this discrepancy compares the kernel-weighted displacement toward nearby data samples with the corresponding displacement toward nearby model samples, thereby defining a transport direction for generated samples. In this paper, we show that drifting is more closely connected to score-based generative modeling than it may first appear, establishing a precise link to the score-matching principle underlying diffusion models. For Gaussian kernels, the population mean-shift field exactly equals the difference between the scores (i.e., the gradient-log-densities) of the Gaussian-smoothed data and model distributions. This identity follows from Tweedie's formula, which links the score of a Gaussian-smoothed density to its conditional mean, and implies that Gaussian-kernel drifting is exactly a score-matching objective on smoothed distributions. More generally, we derive an exact decomposition for radial kernels in which mean shift equals a score-based field plus a residual term. For the practical Laplace kernel, we further show theoretically and empirically that this residual is negligible in high dimension, implying that the transport field used in practice is nearly score-based. Our results reveal a structural connection to diffusion models: both methods use score-mismatch transport directions, but drifting realizes the score nonparametrically through kernel-based estimates, whereas diffusion models learn it parametrically with neural networks.
Learning Structured Robot Policies from Vision-Language Models via Synthetic Neuro-Symbolic Supervision
arXiv:2604.02812v2 Announce Type: replace Abstract: Vision-Language Models (VLMs) have recently demonstrated strong capabilities in mapping multimodal observations to robot behaviors. However, most current approaches rely on end-to-end visuomotor policies that remain opaque and difficult to analyze, limiting their use in real-world robotic applications. In contrast, classical robotic systems often rely on structured policy representations that provide interpretability, modularity, and reactive execution. This work investigates how foundation models can be specialized to generate structured robot policies grounded in multimodal perception, bridging high-dimensional learning and symbolic control. We propose a neuro-symbolic approach in which a VLM synthesizes executable Behavior Tree policies from visual observations, natural language instructions, and structured system specifications. To enable scalable supervision without manual annotation, we introduce an automated pipeline that generates a synthetic multimodal dataset of domain-randomized scenes paired with instruction-policy examples produced by a foundation model. By decoupling structured task decomposition under constrained symbolic grammars from hardware-specific motor control, we demonstrate that a 12B-parameter model can learn structured spatial-symbolic mappings required for executable BT synthesis, solely through in-silico supervision. Real-world physical experiments on two heterogeneous robotic manipulators confirm that these structurally constrained policies achieve zero-shot transfer to real-world environments. The results emphasize that the data bottleneck in robotic planning can be bypassed by procedurally synthesizing high-fidelity, neuro-symbolic training data.
ELDOR: A Dataset and Benchmark for Illegal Gold Mining in the Amazon Rainforest
arXiv:2605.15397v1 Announce Type: new Abstract: Illegal gold mining in the Amazon rainforest causes deforestation, water contamination, and long-term ecosystem disruption, yet remains difficult to monitor at fine spatial scales. Satellite imagery supports large-scale observation, but often misses small mining-related structures and subtle land-cover transitions, especially under frequent cloud cover. We introduce ELDOR, a large-scale UAV benchmark for monitoring environmental and landscape disturbance from illegal gold mining in the rainforest. ELDOR contains manually annotated orthomosaic imagery covering over 2,500 hectares, with pixel-level semantic labels for both mining-related activities and surrounding ecological structures. With this unified annotation source, we establish four benchmark tasks: semantic segmentation, segmentation-derived recognition, direct multi-label classification, and class-presence recognition with vision-language models. Across these tasks, we compare generic and remote-sensing-specific segmentation models, vision foundation model-related segmentation methods, direct multi-label classification methods, and vision-language models under a controlled closed-set protocol. Results show that current methods still struggle with rare small-scale mining structures and fine-grained recovery classes, suggesting the need for context-aware and multimodal modeling. To support domain analysis and practical use, we further build an interactive explorer for domain experts that provides a unified interface for data exploration and model inference.
Where to Perch in a Tree: Vision-Guidance for Tree-Grasping Drones
arXiv:2605.15430v1 Announce Type: new Abstract: This study demonstrates a method to locate an ideal perch location on a tree for vision-guided autonomous tree-perching drones. Various image processing algorithms, including those used for machine learning, image segmentation and binary image morphology, are implemented to assess the shape and structure of a tree. Rather than identifying the closest available branch, this study builds on vision methods by evaluating the potential of each branch, determining its suitability for perching based on factors such as branch width, slope (angle to the horizontal) and curvature. For a given tree-perching drone and a dataset of more than 10,000 urban tree images taken from February to October in a subtropical and temperate monsoon climate, the proposed method successfully produces a result for 76% of feasible targets. A feasible target defined as a tree where the branch diameters are sufficiently thick and where the available perching space is at least equal to the width of a tendon-driven grasping claw. These successful preliminary results create a foundation from which a number of identified improvements and additional features can be developed to create a generalised method; this will involve the incorporation of supplementary data from depth perception and attitude sensors to enhance the branch assessment.
MCAC: A Model Counting Algorithm for Exact Computation of Error Metrics of Approximate Circuits
arXiv:2411.10037v3 Announce Type: replace Abstract: Effective usage of approximate circuits for various performance trade-offs requires accurate computation of error. MCAC is a novel model counting framework for exact computation of several average and worst-case error metrics that are used to evaluate approximate circuits. Unlike other methods in the literature, our framework uses the same error miter for all metrics. It requires a single synthesis of the system consisting of the exact and approximate circuits followed by a subtractor that finds the difference of the two outputs. Existing miter-based methods require multiple calls to the model counter, one for each output of the miter. MCAC uses the CNF formula of the system to compute all metrics. Our algorithm converts the formula to a tree and uses message passing to compute all metrics. We propose data structures to efficiently store and perform sparse computations required for conversion to a tree and message passing. Results for all the error metrics for several benchmark instances show a significant speedup over using off-the-shelf model counters along with specialized miters for each metric.
Enhanced input stacking for non-square MIMO modal identification of aeronautical structures via Fast and Relaxed Vector Fitting
arXiv:2605.16037v1 Announce Type: cross Abstract: Fast and Relaxed Vector Fitting (FRVF) is a frequency-domain system identification approach that has been widely adopted in electrical system modelling, while its application to mechanical systems has remained relatively unexplored. In this work, FRVF is reformulated for the identification of structural modal parameters of an aircraft based on Ground Vibration Test (GVT) data within a Multi-Input Multi-Output (MIMO) framework. The proposed procedure consists of three stages: (i) rational approximation of frequency response functions via an enhanced input-stacking strategy, (ii) identification of system poles from the resulting rational model, and (iii) estimation of modal parameters from the extracted poles and associated residues. The methodology is first numerically validated on a MIMO beam model, with particular emphasis on accuracy and robustness under increasing measurement noise. Subsequently, experimental validation is conducted using GVT data from the BAE Systems Hawk T1A aircraft. The results obtained demonstrate a level of performance comparable to that achieved by existing methods. Overall, the extended MIMO formulation of FRVF exhibits high accuracy and strong robustness to measurement noise, highlighting its suitability for application in GVT-based modal analysis.
How nature discovers rare Turing islands: exploration by common limit cycles
arXiv:2605.15839v1 Announce Type: cross Abstract: Turing patterns are a cornerstone of biological self-organization, yet their emergence typically requires finely tuned parameters occupying narrow regions of high-dimensional space. This poses a fundamental challenge: how can evolving biological systems reliably find and exploit such rare conditions? In this work, we propose that common biochemical limit cycles, such as those arising from genetic feedback loops, can act as natural explorers of Turing space. By coupling a reaction-diffusion system to an orbit that modulates some of its parameters, we show that the system can dynamically sweep through Turing-permissive regimes and generate transient spatial patterns. We use an entropy-based measure in Fourier space to quantify pattern formation and demonstrate how cycles enhance the detectability and robustness of Turing islands. We further explore how coupling to positional gradients increases reproducibility, suggesting a route from oscillatory dynamics to stable developmental programs. Our results highlight a powerful mechanism by which nature might bootstrap complex spatial structure from simple temporal motifs.
Markov State Model for the forced unfolding of a small peptide
arXiv:2605.15805v1 Announce Type: cross Abstract: In typical single-molecule force spectroscopy experiments the mechanical unfolding of molecular complexes or biomolecules is studied applying a force ramp to one end of the system while the other end is kept fixed in space. The computational counterpart of this type of experiments can routinely be performed using molecular dynamics simulations with atomistic resolution. However, due to the large difference in time scales often coarse graining procedures are applied in the simulations. Most of the applied techniques do not allow to follow the atomistic details of the relevant conformational transitions due to the structural simplifications used to speed up the simulations. Here, we apply an earlier developed dynamic coarse graining technique based on Markov state modeling to a model peptidic system that does not unfold in a simple two-state manner. Using the donor-acceptor distances of the helical hydrogen bonds as collective variables and performing a dimension reduction technique allows us to construct a Markov model of the unfolding process that correctly represents the microscopic behavior of the system. The chosen example shows that the method can be used to mimick the mechanical unfolding process of systems for which the end-to-end distance does not provide a sufficient order parameter and that do not unfold in a simple cooperative manner.
ViewBridge: Curriculum Knowledge Distillation for Activity View-Invariance Under Extreme Viewpoint Changes
arXiv:2504.05451v2 Announce Type: replace Abstract: Traditional methods for view-invariant learning rely on controlled multi-view training data with minimal scene clutter. However, they struggle with in-the-wild videos that exhibit extreme viewpoint differences and share little visual content. We introduce ViewBridge, a framework for learning rich video representations in the presence of severe view-occlusions. We introduce a knowledge distillation objective that preserves action-centric semantics, together with a novel curriculum learning procedure that pairs incrementally more challenging views over time, thereby allowing smooth adaptation to extreme viewpoint differences. To sort training video segments for the proposed curriculum, we define a geometry-based metric that reflects their likely occlusion level. While training leverages multi-view data, at inference time, the input is an uncalibrated, single-viewpoint video. Evaluating our approach on two tasks -- temporal keystep grounding and fine-grained keystep recognition -- we outperform SOTA approaches across three datasets (Ego-Exo4D, LEMMA, EPFL-Smart-Kitchen-30). Project page: https://vision.cs.utexas.edu/projects/learning_view_distill/ .
Active Redundancy Allocation Strategy at Component and System Level
arXiv:2605.15823v1 Announce Type: cross Abstract: Researchers and practitioners in the field of reliability engineering and optimization frequently use active redundancy techniques to intensify the performance of systems. In this article, we study allocation strategies of non-matching active redundancies (spares) in coherent systems consisting of possibly dependent and identical components for achieving better system reliability. The dependence of the components is modeled through copulas using the distortion function. Sufficient conditions are derived to establish optimal allocation strategies for two heterogeneous active redundancies at the component or system levels. Moreover, the results are true for the component lifetimes following a general family of parametric distributions. The results guarantee the likelihood ratio (reversed hazard) ordering between the coherent systems at the component level (system level) active redundancies. Some aging properties are also established in this endeavor. Several examples are provided to demonstrate the theoretical results.
A Scalable Nonparametric Continuous-Time Survival Model through Numerical Quadrature
arXiv:2605.16208v1 Announce Type: cross Abstract: Flexible continuous-time survival modeling is critical for capturing complex time-varying hazard dynamics in high-dimensional data; however, training such models remains challenging due to the intractable integral required for likelihood estimation. We introduce QSurv, a scalable deep learning framework that enables nonparametric continuous-time modeling without relying on time discretization or restrictive distributional assumptions. We propose a training objective based on Gauss-Legendre numerical quadrature, which approximates the cumulative hazard with high-order accuracy while facilitating efficient end-to-end training via standard backpropagation. Furthermore, to effectively capture non-stationary hazard dynamics in complex architectures, we introduce time-conditioned low-rank adaptation, a mechanism that conditions general neural backbones on time by dynamically modulating weights via low-rank updates. We provide theoretical analysis establishing approximation error bounds for cumulative-hazard evaluation. Comprehensive experiments across synthetic benchmarks, large-scale real-world tabular datasets, and high-dimensional medical imaging tasks demonstrate that QSurv achieves competitive predictive performance with advantages in instantaneous hazard function estimation, enabling more interpretable characterization of time-varying risk patterns.
On the parameterized complexity of Broadcast Independence and Broadcast Packing
arXiv:2605.16001v1 Announce Type: new Abstract: A broadcast on a connected graph is a function f that assigns each vertex v an integer f(v) with 0 <= f(v) <= ecc(v) where ecc(v) denotes the eccentricity of v. A vertex u hears a broadcasting vertex v (with f(v)>0) if u is at distance at most f(v) from v. Beyond the classical broadcast domination problem, where every vertex is required to hear at least one vertex, two variants raise intriguing combinatorial and algorithmic questions. In an independent broadcast, no broadcasting vertex hears another broadcasting vertex, while a broadcast packing requires that every vertex hears at most one broadcasting vertex. The corresponding problems Broadcast Independence and Broadcast Packing ask for broadcasts of values at least k under these constraints, where the value is the sum of the broadcast values. We initiate a systematic study of the parameterized complexity of such problems. We prove that Broadcast Independence and Broadcast Packing are FPT parameterized by the treewidth plus the diameter of G, with a family of dynamic-programming algorithms over nice tree decompositions. We obtain as a corollary that both problems are FPT parameterized by k and the treewidth of G and XP for treewidth only. The latter result shows that the known algorithm for trees (Bessy and Rautenbach, DAM 2022) can indeed be extended to bounded treewidth graphs. On the negative side, we show that Broadcast Independence is W[1]-hard parameterized by the pathwidth of G. Note that this result completes the picture for parameter k and treewidth for Broadcast Independence since it is known to be W[1]-hard for k only. We complement these results by showing that a weighted version of both problems, where the input comes with a weight function on the edges, is W[1]-hard parameterized by the vertex cover of G. Finally, we provide a constant-factor approximation algorithm parameterized by treewidth for Broadcast Independence.
Tube Loss: A Novel Approach for Prediction Interval Estimation
arXiv:2412.06853v4 Announce Type: replace Abstract: This paper proposes a novel loss function, called 'Tube Loss', for simultaneous estimation of bounds of a Prediction Interval (PI) in the regression setup. The PIs obtained by minimizing the empirical risk based on the Tube Loss are shown to be of better quality than the PIs obtained by the existing methods in the following sense. First, it yields intervals that attain the prespecified confidence level t $\in$ (0,1) asymptotically. A theoretical proof of this fact is given. Secondly, the user is allowed to move the interval up or down by controlling the value of a parameter. This helps the user to choose a PI capturing denser regions of the probability distribution of the response variable inside the interval, and thus, sharpening its width. This is shown to be especially useful when the conditional distribution of the response variable is skewed. Further, the Tube Loss based PI estimation method can trade-off between the coverage and the average width by solving a single optimization problem. It enables further reduction of the average width of PI through re-calibration. Also, unlike a few existing PI estimation methods the gradient descent (GD) method can be used for minimization of empirical risk. Through extensive experiments, we demonstrate the effectiveness of Tube Loss-based PI estimation in both kernel machines and neural networks. Additionally, we show that Tube Loss-based deep probabilistic forecasting models achieve superior performance compared to existing probabilistic forecasting techniques across several benchmark and wind datasets. Finally, we empirically validate the advantages of the Tube loss approach within the conformal prediction framework. Codes are available at https://github.com/ltpritamanand/Tube$\_$loss.
Convergent Representations of Linguistic Constructions in Human and Artificial Neural Systems
arXiv:2603.29617v2 Announce Type: replace-cross Abstract: Understanding how the brain processes linguistic constructions is a central challenge in cognitive neuroscience and linguistics. Recent computational studies show that artificial neural language models spontaneously develop differentiated representations of Argument Structure Constructions (ASCs), generating predictions about when and how construction-level information emerges during processing. The present study tests these predictions in human neural activity using electroencephalography (EEG). Ten native English speakers listened to 200 synthetically generated sentences across four construction types (transitive, ditransitive, caused-motion, resultative) while neural responses were recorded. Analyses using time-frequency methods, feature extraction, and machine learning classification revealed construction-specific neural signatures emerging primarily at sentence-final positions, where argument structure becomes fully disambiguated, and most prominently in the alpha band. Pairwise classification showed reliable differentiation, especially between ditransitive and resultative constructions, while other pairs overlapped. Crucially, the temporal emergence and similarity structure of these effects mirror patterns in recurrent and transformer-based language models, where constructional representations arise during integrative processing stages. These findings support the view that linguistic constructions are neurally encoded as distinct form-meaning mappings, in line with Construction Grammar, and suggest convergence between biological and artificial systems on similar representational solutions. More broadly, this convergence is consistent with the idea that learning systems discover stable regions within an underlying representational landscape - recently termed a Platonic representational space - that constrains the emergence of efficient linguistic abstractions.
T Count as a Numerically Solvable Minimization Problem
arXiv:2603.25101v2 Announce Type: replace-cross Abstract: We present a formulation of the problem of finding the smallest T -Count circuit that implements a given unitary as a binary search over a sequence of continuous minimization problems, and demonstrate that these problems are numerically solvable in practice. We reproduce best-known results for synthesis of circuits with a small number of qubits, and push the bounds of the largest circuits that can be solved for in this way. Additionally, we show that circuit partitioning can be used to adapt this technique to be used to optimize the T -Count of circuits with large numbers of qubits by breaking the circuit into a series of smaller sub-circuits that can be optimized independently.
Neural simulation-based inference of the Higgs trilinear self-coupling via off-shell Higgs production
arXiv:2507.02032v2 Announce Type: replace-cross Abstract: One of the forthcoming major challenges in particle physics is the experimental determination of the Higgs trilinear self-coupling. While efforts have largely focused on on-shell double- and single-Higgs production in proton-proton collisions, off-shell Higgs production has also been proposed as a valuable complementary probe. In this article, we design a hybrid neural simulation-based inference (NSBI) approach to construct a likelihood of the Higgs signal incorporating modifications from the Standard Model effective field theory (SMEFT), relevant background processes, and quantum interference effects. It leverages the training efficiency of matrix-element-enhanced techniques, which are vital for robust SMEFT applications, while also incorporating the practical advantages of classification-based methods for effective background estimates. We demonstrate that our NSBI approach achieves sensitivity close to the theoretical optimum and provide expected constraints for the high-luminosity upgrade of the Large Hadron Collider. While we primarily concentrate on the Higgs trilinear self-coupling, we also consider constraints on other SMEFT operators that affect off-shell Higgs production.
The Right Answer, the Wrong Direction: Why Transformers Fail at Counting and How to Fix It
arXiv:2605.03258v2 Announce Type: replace Abstract: Large language models often fail at simple counting tasks, even when items to count are in the prompt. We investigate whether this failure occurs because transformers do not represent counts internally, or because they cannot convert representations to the correct output tokens. Across three model families: Pythia, Qwen3, and Mistral, ranging from 0.4B to 14B parameters, we find evidence for the second explanation. Linear probes recover the correct count from intermediate layers with $R^2>0.99$, showing that the information is present. However, the internal directions that encode counts are nearly orthogonal to digit-token output-head rows ($|\cos| \leq 0.032$). In other words, the model stores the count in a form that the digit logits do not naturally read out. We localize this failure with two interventions. Updating only the digit rows of the output head (36,864 parameters) substantially improves constrained digit prediction (60.7--100.0% on four tasks), but it does not fix unconstrained generation (0%); we do not claim that digit-row repair fixes open-ended text. By contrast, small LoRA on attention Q/V (7.67M parameters) improves upstream routing and achieves 83.1%$\pm$7.2% in true greedy autoregressive generation (deployable fix). Logit-lens at layer 35 (entity counting; correct-digit rank): (i) median over 3 seeds drops from order-$10^4$ to 1; (ii) seed 42 shows $54{,}332 \to 838$ (median top-1 while one seed stays far below). Norm, logit-lens, and cross-task analyses generalize the bottleneck to counting, addition, and list length; nulls on MMLU and GSM8K and limited DROP transfer. These results identify counting failure as a geometric readout bottleneck, not an internal-representation failure: the model knows the count but the output pathway is misaligned with tokens needed to express it.
Actin cross-linking organizes basal body patterning through anomalous diffusion transitions
arXiv:2605.15912v1 Announce Type: cross Abstract: Subcellular protein complexes and organelles exhibit diverse dynamic behaviors that reflect the mechanical constraints and organization of the intracellular environment. Although some structures follow classical Brownian motion, many display anomalous dynamics. The transitions between these regimes are increasingly recognized as critical for subcellular organization, yet how they influence pattern formation remains unclear. Here, we investigate the spatial arrangement of cilia on the apical surface of multiciliated cells (MCCs) in developing Xenopus laevis embryos, where coordinated ciliary beating depends on the precise organization of hundreds of centriole-derived basal bodies (BBs). Using quantitative confocal, high-resolution and high-speed TIRF imaging together with theoretical modeling, we show that BB trajectories undergo time-resolved transitions between diffusive and anomalous motion, with distinct regimes that correlate with apical surface expansion. During the early stages, actin remodeling facilitates the dispersal of BBs by providing a permissive, low-confinement environment. As development progresses, the actin network becomes increasingly cross-linked that constrains BB movement and promotes uniform spacing across the apical domain. Disruption of $\alpha$-actinin-1, a major actin cross-linking protein, impairs the integrity of the apical actin meshwork, weakens BB confinement, and disrupts regular spatial patterning, ultimately compromising the arrangement of BBs required for proper cilia alignment. Together, we show that progressive apical actin cross-linking coordinates BB positioning and regulates their dynamic state, guiding the shift from diffusive to confined motion. This transition in dynamics enables the emergence of a uniform BB pattern, which in turn ensures the aligned deployment of motile cilia necessary for effective directional fluid flow.
End-to-end plaque counting and virus titration from laboratory plate images with deep learning
arXiv:2605.16008v1 Announce Type: new Abstract: Plaque assays remain the gold standard readout of virus infectivity; however, plaque counting from plate images is labor-intensive and prone to inter-operator variability. We present an end-to-end, computer-aided workflow for cytopathic effect-based virus titration directly from laboratory plaque assay images. The proposed approach combines two models derived from the Segment Anything Model (SAM): a SAM2-based well-segmentation module that localizes assay wells across heterogeneous imaging conditions, and a SAM-based plaque-segmentation model that detects and enumerates plaques within each well. The method was evaluated on a mixed dataset comprising private plaque assay images of Mayaro virus and Coxsackievirus B3, together with public Vaccinia virus images from the VACVPlaque dataset. The pipeline outputs per-well plaque counts, automatically computes plaque-forming units per milliliter (PFU/mL), and is integrated into a web-based platform that allows users to review results and organize experiments. On held-out plates (17 from MAYV/CVB3 and 22 from VACV), the workflow generalized across two plate formats (6-well and 12-well) and showed strong agreement with manual annotations (Pearson correlation coefficients of 0.92 for MAYV/CVB3 and 0.88 for VACV). Automated plaque counts were further compared with annotations from four independent experts, demonstrating high concordance. The proposed system will be open sourced and publicly released upon acceptance of this manuscript to enable reproducible, scalable, and audit-ready plaque assay analysis while substantially reducing manual annotation effort.
Massively Degenerate Coherent Perfect Absorption in Gradient-Index Fibers
arXiv:2605.15998v1 Announce Type: new Abstract: Coherent perfect absorbers (CPAs) have recently attracted considerable attention due to their ability to enhance light--matter interaction. By exploiting interference, CPAs enable even weakly absorbing materials to achieve complete absorption under appropriate excitation conditions. Generalizing this concept to the simultaneous absorption of arbitrary multimode input states remains challenging, however, since conventional implementations typically operate only for a single or a very small number of input channels. Here, we propose a compact realization of a multimode coherent perfect absorber based on a gradient-index (GRIN) fiber. Using the self-imaging property of the fiber, the bulky free-space architecture of previous approaches is replaced by a monolithic waveguiding platform that supports near-degenerate rephasing of many spatial modes. We show that standard GRIN profiles optimized for minimal intermodal dispersion enable highly efficient absorption of complex multimode fields, with field-of-view reflectivities well below \(1\%\) for realistic parameters. This approach provides a practical and scalable route toward efficient multimode absorption in fiber-based and integrated photonic systems, with potential applications in light harvesting, optical control, and imaging.
BEACON: A Multimodal Dataset for Learning Behavioral Fingerprints from Gameplay Data
arXiv:2605.10867v2 Announce Type: replace Abstract: Continuous authentication in high-stakes digital environments requires datasets with fine-grained behavioral signals under realistic cognitive and motor demands. But current benchmarks are often limited by small scale, unimodal sensing or lack of synchronised environmental context. To address this gap, this paper introduces BEACON (Behavioral Engine for Authentication & Continuous Monitoring), a large-scale multimodal dataset that captures diverse skill tiers in competitive Valorant gameplay. BEACON contains approximately 430 GB of synchronised modality data (461 GB total on-disk including auxiliary Valorant configuration captures) from 79 sessions across 28 distinct players, estimated at 102.51 hours of active gameplay, including high-frequency mouse dynamics, keystroke events, network packet captures, screen recordings, hardware metadata, and in-game configuration context. BEACON leverages the high precision motor skills and high cognitive load that are inherent to tactical shooters, making it a rigorous stress test for the robustness of behavioral biometrics. The dataset allows for the study of continuous authentication, behavioral profiling, user drift and multimodal representation learning in a high-fidelity esports setting. The authors release the dataset and code on Hugging Face and GitHub to create a reproducible benchmark for evaluating next-generation behavioral fingerprinting and security models.