Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-71794-1Model building in cryo-EM strongly depends on its map quality. Here, the authors propose EMReady2, a generalist tool for fast improvement of cryo-EM and cryo-ET maps at 2–10 Å resolutions with local quality-aware deep learning.
Science Journals
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73190-1Mucosal melanoma is a rare and aggressive subtype which, unlike cutaneous melanoma, shows limited response to immune checkpoint inhibition. Here, the authors report the safety and efficacy of neoadjuvant pembrolizumab (anti-PD-1) and lenvatinib (multi tyrosine kinase inhibition) in patients with resectable mucosal melanoma, along with exploratory biomarker analysis.
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-72870-2Organophosphoryl compounds are important motifs, however regioselective phosphorylation of alkenes remains challenging. Here, the authors report a visible light driven triple catalytic strategy enabling radical Markovnikov hydrophosphorylation of unactivated alkenes via sequential reaction of (bis)homoallylic alcohols, Ph₂PCl, and water.
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73239-1Restart of failed DNA replication processes is essential but poorly understood. Here, the authors present cryoEM structures of two preprimosome complexes, revealing how the PriA/PriB/DnaT complex assembles and matures. The findings suggest a possible DnaA-like mechanism for replisome recruitment.
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73246-2Extreme rainfall will intensify across Africa under future warming, with the largest increases expected in equatorial regions. This intensification is driven primarily by increased atmospheric moisture associated with radiation-induced warming.
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73099-9Combining high-throughput molecular simulations, machine learning, and mixed-integer linear programming, the authors design peptides that localize to condensate interfaces, revealing surfactant-like, charge-dependent sequence rules.
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-72366-zThe contrasting roles of epithelial tissues in providing flexibility while maintaining integrity are not yet well understood. Here, the authors show that this need can be fulfilled by keratin intermediate filaments cross talking to other cytoskeletal machinery across the developing epithelium.
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73187-wHere, the authors show that the interplay of oxygen vacancies and erbium emitters in bismuth oxyhalides enables reversible, high-contrast switching of upconversion emission, offering a new strategy for high-level anticounterfeiting.
A molecular basis for stoichiometric enzyme encapsulation in the vitamin B2 biosynthesis compartment
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73260-4Many bacteria sequester enzymes within protein cages for efficient vitamin B2 production. Cryo-EM captures rare cage assembly intermediates, revealing multilayered mechanisms behind architectural precision.
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-72913-8Purifying electronic-grade propylene is challenging due to trace impurities. Here, authors demonstrate a ZIF-8 membrane that efficiently removes impurities at low temperatures, enabling high-purity propylene production with reduced energy and cost.
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73300-zMany cancers depend on RAS signaling, but blocking diverse RAS mutants remains challenging. Here, authors engineer a protein-based pan-RAS inhibitor that induces tumor regression in mouse models and reveals an immune-dependent mechanism of action