Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
Science Journals
The American College of Obstetricians & Gynecologists (ACOG) released a maternal immunization schedule for 2026, the first time the organization has issued formal vaccine guidance that does not align with federal recommendations.
Delirium after surgery may be a strong predictor of long-term cognitive decline in older adults independent of illness or frailty, a recent study suggests.
Approximately 19% of US adolescents and young adults reported using an artificial intelligence (AI) chatbot for mental health advice in 2025, according to a study published in JAMA Pediatrics.
Ultraprocessed food consumption may be associated with cardiometabolic risk factors, certain diseases, and all-cause mortality, a recent study found.
This Medical News article is an interview with Rita Kalyani, MD, MHS, the American Diabetes Association’s chief scientific and medical officer and a professor of medicine at Johns Hopkins University School of Medicine, about research presented at the organization’s annual Scientific Sessions.
This Perspective discusses progress made in Alzheimer disease prevention during the last 50 years.
This narrative review discusses the pathophysiology, epidemiology, clinical presentation, diagnosis, and treatment of nonspecific low back pain.
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
This study examines trends in US nursing home closures, characterizing facilities that closed during 2016-2025, and assessing implications for access to care.
JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, spoke with Yun Liu, PhD, a senior staff research scientist at Google Research, for JAMA+ AI Conversations about the promise of AI in medical imaging.
This cross-sectional study reports on the changes in allocation of resident training spots by specialties and rurality and assesses whether newly allocated positions meet the targets set by Consolidated Appropriations Acts of 2021 and 2023.
The Perspective titled “When Disregard for Population Health Becomes US Policy” published March 16, 2026, was corrected to fix the mortality data reported at the end of the third paragraph. The article incorrectly stated that all-cause mortality at ages 25-64 years increased by 19.6% between 2010 and 2019. During this period, all-cause mortality increased by 5.2% among those aged 25-64 years and 19.6% among those aged 25-44 years. This article has been corrected online.
Today’s high-fidelity phonograph systems owe their existence to a discovery by Thomas A. Edison, who in 1876 hit on a method that permitted both recording and reproduction of sound from a rotating cylinder. After a number of attempts had been made to convert his machine from a cylinder into a standard phonograph, the phonograph industry was born at the turn of the century.
To the Editor Dr Short and colleagues provided a timely and clinically meaningful update on perinatal HIV management, including the expanded role of shared decision-making for breastfeeding among individuals with sustained viral suppression receiving antiretroviral therapy (ART). As these recommendations are increasingly incorporated into US clinical practice, an additional consideration is the dynamic nature of virologic control in the postpartum period.
Every clinician recalls moments during patient care when time seems to have stopped. Such stunning events, most typically at crucial junctures in patients’ lives—a child’s birth, a final breath—are indelibly part of medicine. Poetry is also notable for its ability to seemingly suspend time, making it suitable for marking such momentous life changes. The poem “Post Code” demonstrates several techniques that give poetry its time-stopping powers, highlighted by its medical context. It is first and foremost a lyric, the poetic genre typically composed in a kind of eternal present tense, even when referring to past events. When John Keats wrote to the figures on his Grecian urn, he addressed them as permanently alive—“Bold Lover, never, never canst thou kiss”—freezing them (and us) in a moment that never arrives and never passes. We find ourselves similarly frozen in “Post Code,” transfixed by the code room’s smells of “pennies and plastic” while the patient’s daughter’s hands forever grip the bed rail. Poetry also forces slowed-down reading, with its interceding line breaks and freighted punctuation; we linger over such arresting lines as “Outside, the hallway laughs—/a coffee joke, a shift trade—,” set off by cliffhanging dashes, or (more literally perhaps) “waiting for the monitor to change its mind.” Finally, poetry’s capacity for expressing epiphanies, those timeless, exalted realizations made possible by art’s existence outside of time, also occurs here, as in the poem’s final line: “and the day keeps walking past this door,” reminding us that the clinician’s healing work transcendently continues.
To the Editor The Special Communication from ESGO provided an important and timely synthesis of the evidence supporting opportunistic salpingectomy for tubo-ovarian carcinoma prevention. The biological rationale is compelling, and observational data consistently demonstrate substantial relative risk reduction, which justifies inclusion of salpingectomy in preoperative counseling for eligible women. However, counseling must remain broader than a single preventive surgical intervention.
This Viewpoint discusses the reasons why it is important for individuals to continue to receive the tetanus vaccine.
To the Editor Dr Harris and colleagues presented a timely and comprehensive Review of pharmacological treatments for opioid use disorder. The section on overdose management is detailed and well structured, placing appropriate emphasis on naloxone and summarizing the most recent evidence supporting its effectiveness. However, despite the broad scope of the Review, nalmefene was not discussed. Nalmefene is an opioid antagonist approved for alcohol use disorder and, more recently, for the reversal of opioid overdose. It first received US Food and Drug Administration (FDA) approval in 1995 as an injectable agent for overdose reversal but was withdrawn from the market approximately a decade later. A new approval was granted in 2023, when the FDA authorized an intranasal formulation for opioid overdose. Subsequently, in 2024, an autoinjector formulation (for subcutaneous or intramuscular administration) was also approved for the same indication.
In Reply We thank Dr Palma-Álvarez for his thoughtful Letter regarding our Review of medications for opioid use disorder, withdrawal, and overdose. He appropriately highlights the pharmacological properties of the opioid antagonist nalmefene and raises an important point about the evolving availability of opioid antagonists.
In this narrative medicine essay, a facial plastic surgeon who specializes in treating rare and complex operations, so-called zebras, describes how the excruciating pain in his right leg turned out to be a zebra.
This JAMA Patient Page describes how Ebola is transmitted, how common the infection is and where outbreaks have occurred, risk factors and symptoms, and how it is diagnosed and treated.
Blood-based multicancer detection (MCD) technologies have been touted as a revolution in early-stage population screening and testing for a wide range of cancers. MCDs (often called liquid biopsies) look for fragments of DNA and other biomarkers in the blood, which may indicate the presence of cancer and predict where it originated. The seductive premise has been clear: detecting cancer earlier and intervening at an earlier stage will cure more patients. Given this promise, the commercial market has grown to more than 24 companies, and the annual global market for these MCD technologies is estimated to reach US $2.9 billion by 2030.
This Viewpoint discusses some specific challenges in defining estimands for cluster randomized trials and illustrates how the CRT-Estimands Framework can be applied to improve the interpretation of trial results.