arXiv:2508.15151v3 Announce Type: replace-cross
Abstract: Computed tomography (CT) is important in clinical diagnosis, but acquiring high-resolution (HR) CT is constrained by radiation exposure risks. While deep learning-based super-resolution (SR) methods have shown promise for reconstructing HR CT from low-resolution (LR) inputs, supervised approaches require paired datasets that are often unavailable. Zero-shot methods address this limitation by operating on single LR inputs; however, they frequently fail to recover fine structural details due to limited LR information within individual volumes. To overcome these limitations, we propose a novel zero-shot 3D CT SR framework that integrates diffusion-based upsampled 2D projection priors into the 3D reconstruction process. Specifically, our framework consists of two stages: (1) LR CT projection SR, training a diffusion model on abundant X-ray data to upsample LR projections, thereby enhancing the scarce information inherent in the LR inputs. (2) 3D CT volume reconstruction, using 3D Gaussian splatting with our novel Negative Alpha Blending (NAB-GS), which models positive and negative Gaussian densities to learn signed residuals between diffusion-generated HR and upsampled LR projections. Our framework demonstrates superior quantitative and qualitative performance on two public datasets, and expert evaluations present the framework's clinical potential at 4x.
Science Journals
arXiv:2509.24100v2 Announce Type: replace-cross
Abstract: Conformal prediction provides distribution-free prediction sets with finite-sample conditional guarantees. We build upon the RKHS-based framework of Gibbs et al. (2023), which leverages families of covariate shifts to provide approximate conditional conformal prediction intervals, an approach with strong theoretical promise, but with prohibitive computational cost. To bridge this gap, we develop a stable and efficient algorithm that computes the full solution path of the regularized RKHS conformal optimization problem, at essentially the same cost as a single kernel quantile fit. Our path-tracing framework simultaneously tunes hyperparameters, providing smoothness control and data-adaptive calibration. To extend the method to high-dimensional settings, we further integrate our approach with low-rank latent embeddings that capture conditional validity in a data-driven latent space. Empirically, our method provides reliable conditional coverage across a variety of modern black-box predictors, improving the interval length of Gibbs et al. (2023) by 30%, while achieving a 40-fold speedup.
arXiv:2512.24816v2 Announce Type: replace-cross
Abstract: We present a generalizable scale-bridging computational framework that enables predictive modeling of insertion-type electrode materials from atomistic to device scales. Applied to sodium manganese hexacyanoferrate, a promising cathode material for grid-scale sodium-ion batteries, our methodology employs an active-learning strategy to train a Moment Tensor Potential through iterative hybrid grand-canonical Monte Carlo--molecular dynamics sampling, robustly capturing configuration spaces at all sodiation levels. The resulting machine learning interatomic potential accurately reproduces experimental properties including volume expansion, operating voltage, and sodium concentration-dependent structural transformations, while revealing a four-order-of-magnitude difference in sodium diffusivity between the rhombohedral (sodium-rich) and tetragonal (sodium-poor) phases at 300 K. We directly compute all critical parameters -- temperature- and concentration-dependent diffusivities, interfacial and strain energies, and complete free-energy landscapes -- to feed them into pseudo-2D phase-field simulations that predict phase-boundary propagation and rate-dependent performances across electrode length scales. This multiscale workflow establishes a blueprint for rational computational design of next-generation insertion-type materials, such as battery electrode materials, demonstrating how atomistic insights can be systematically translated into continuum-scale predictions.
arXiv:2601.00502v2 Announce Type: replace-cross
Abstract: The impact of both multiplicative and additive hardware impairments (HWIs) on multiple-input multiple-output affine frequency division multiplexing (MIMO-AFDM) systems is investigated. For small-scale MIMO-AFDM systems, a tight bit error rate (BER) upper bound associated with the maximum likelihood (ML) detector is derived. By contrast, for large-scale systems, a closed-form BER approximation associated with the linear minimum mean squared error (LMMSE) detector is presented, including realistic imperfect channel estimation scenarios. Our first key observation is that the full diversity order of a hardware-impaired AFDM system remains unaffected, which is a unique advantage. Furthermore, our analysis shows that 1) the BER results derived accurately predict the simulated ML performance in moderate-to-high signal-to-noise ratios (SNRs), while the theoretical BER curve of the LMMSE detector closely matches that of the Monte-Carlo based one. 2) MIMO-AFDM is more resilient to multiplicative distortions, such as phase noise and carrier frequency offset, compared to its orthogonal frequency division multiplexing (OFDM) counterparts. This is attributed to its inherent chirp signal characteristics; 3) MIMO-AFDM consistently achieves superior BER performance compared to conventional MIMO-OFDM systems under the same additive HWI conditions, as well as different velocity values. The latter is because MIMO-AFDM is also resilient to the additional inter-carrier interference (ICI) imposed by the nonlinear distortions of additive HWIs. In a nutshell, compared to OFDM, AFDM demonstrates stronger ICI resilience and achieves the maximum full diversity attainable gain even under HWIs, thanks to its intrinsic chirp signalling structure as well as to the beneficial spreading effect of the discrete affine Fourier transform.
arXiv:2601.03064v2 Announce Type: replace-cross
Abstract: Similarity-sensitive entropy measures the uncertainty of a probability law relative to a similarity kernel that encodes the distinguishability between states. We develop a measure-theoretic treatment covering both finite similarity matrices and general probability spaces, and study how the law and similarity kernel transform under measurable maps, Markov kernels (channels), and conditioning operations. This yields deterministic and channel data-processing inequalities, so a reduction in entropy quantifies how much distinguishability is lost under representation change. We also define a conditional similarity sensitive entropy theory, give a counterexample to a recent conjecture on concavity, and identify a useful one-dimensional Laplace pullback class where concavity holds.
arXiv:2605.30015v1 Announce Type: new
Abstract: Supervised Causal Learning (SCL) has shown promise in causal discovery by framing it as a supervised learning problem. However, it suffers from significant out-of-distribution generalization challenges. We reveal three limitations of previous SCL practices: a significant performance gap between synthetic benchmarks and real-world data, fragility to distribution shifts, and failure in compositional generalization, collectively questioning its real-world applicability. To address this, we propose Test-Time Training for Supervised Causal Learning (TTT-SCL), a novel framework that dynamically generates training sets explicitly aligned with any specific test instance. We demonstrate the correlation between TTT-SCL and score-based methods, and design an efficient module for generating training sets based on the classic scoring function. Experiments on synthetic benchmarks, pseudo-real and real-world datasets demonstrate that TTT-SCL significantly outperforms existing SCL and traditional causal discovery methods.
arXiv:2601.15263v2 Announce Type: replace-cross
Abstract: Quantum theory is widely regarded as fundamentally indeterministic, yet classical frameworks can also exhibit indeterminism once infinite information is abandoned. At the same time, relativity is usually taken to forbid superluminal signalling, although Lorentz symmetry formally admits superluminal transformations (SpTs). Dragan and Ekert have argued that SpTs entail a form of indeterminism analogous to that encountered in quantum theory. Here, we derive a theory-independent no-go theorem from a set of natural assumptions: any framework admitting non-order-preserving SpTs must either abandon finite information, relinquish time-symmetric informational content, deny that the past stores memory, or abandon the notion that time determines a preferred causal ordering. In particular, one possible implication is that any theory accommodating SpTs suggests an ontology with unbounded informational content, akin to deterministic classical theories formulated over the real numbers. Consequently, any ontic indeterminacy associated with superluminal transformations cannot originate from finite information.
arXiv:2602.00324v2 Announce Type: replace-cross
Abstract: Synchronization over the special Euclidean group SE(3) aims to recover absolute poses from noisy pairwise relative transformations and is a core primitive in robotics and 3D vision. Standard approaches often require multi-step heuristic procedures to recover valid poses, which are difficult to analyze and typically lack theoretical guarantees. This paper adopts a dual quaternion representation and formulates SE(3) synchronization directly over the unit dual quaternion. A two-stage algorithm is developed: A spectral initializer computed via the power method on a Hermitian dual quaternion measurement matrix, followed by a dual quaternion generalized power method (DQGPM) that enforces feasibility through per-iteration projection. The estimation error bounds are established for spectral estimators, and DQGPM is shown to admit a finite-iteration error bound and achieves linear error contraction up to an explicit noise-dependent threshold. Experiments on synthetic benchmarks and real-world multi-scan point-set registration demonstrate that the proposed pipeline improves both accuracy and efficiency over representative matrix-based methods.
arXiv:2603.20329v2 Announce Type: replace-cross
Abstract: We study the ill-posed problem of recovering a probability measure flow from finitely many moving localized sensors using a Bayes Hilbert framework. Relative to a fixed reference probability measure, a probability law is represented by its centered log-ratio coordinates, so that an evolving law becomes a path in a Hilbert space of functions. For sufficiently regular Bayes Hilbert paths, we construct a canonical minimum-energy transport realization of the path by solving a weighted Neumann problem at each time, yielding an intrinsic transport form on tangent directions.
We then formulate an inverse problem directly on Bayes Hilbert path space. Linearization of an observation operator yields an observability form, and recoverability is governed by its interaction with the transport geometry through a joint transport--observability form. In the ambient infinite-dimensional setting, we develop a regularized variational theory and identify limitations of localized sensing: mobile sensors can make the joint form injective, but they do not in general yield a coercive stability estimate on the full state space.
This obstruction leads naturally to finite-dimensional Bayes Hilbert reductions. There the transport form becomes a kinetic tensor and the linearized observations become reduced sensing matrices, so recoverability can be expressed through explicit Gramian conditions. We show that localized bump sensors detect every fixed reduced direction, that finitely many suitably placed static sensors yield uniform reduced observability, and there exist path-dependent sensor trajectories such that even a single moving sensor can recover the reduced path. Finally, we show that these reduced recovery results lift to approximate ambient recovery for paths that are well approximated by the chosen finite-dimensional subspaces, yielding stable reconstruction up to projection error.
arXiv:2604.13147v2 Announce Type: replace-cross
Abstract: This paper studies continuous-time stochastic control problems whose controlled states are fully non-Markovian and depend on unknown model parameters. Such problems arise naturally in path-dependent stochastic differential equations, rough-volatility hedging, and systems driven by fractional Brownian motion. Building on the discrete skeleton approach developed in earlier work, we propose a Monte Carlo learning methodology for the associated embedded backward dynamic programming equation. Our main contribution is twofold. First, we construct explicit dominating training laws and Radon--Nikodym weights for several representative classes of non-Markovian controlled systems. This yields an off-model training architecture in which a fixed synthetic dataset is generated under a reference law, while the dynamic programming operators associated with a target model are recovered by importance sampling. Second, we use this structure to design an adaptive update mechanism under parametric model uncertainty, so that repeated recalibration can be performed by reweighting the same training sample rather than regenerating new trajectories. For fixed parameters, we establish non-asymptotic error bounds for the approximation of the embedded dynamic programming equation via deep neural networks. For adaptive learning, we derive quantitative estimates that separate Monte Carlo approximation error from model-risk error. Numerical experiments illustrate both the off-model training mechanism and the adaptive importance-sampling update in structured linear-quadratic examples.
arXiv:2605.20560v2 Announce Type: replace
Abstract: The reconfigurable coupler antenna (RCA), also called the flexible coupler antenna (FCA), is a new technique that aims to improve the performance of wireless communication networks by reconfiguring the positions and rotations of low-cost couplers around fixed-position active antennas to harness mutual coupling. Specifically, different couplers can independently adjust their positions and/or rotations at the transceiver to reshape the induced currents on the couplers for radiation, thereby collaboratively achieving mechanical beamforming for directional signal enhancement or nulling. The position and/or rotation reconfiguration of passive couplers provides a new and cost-effective means of enhancing wireless communication performance, while significantly reducing the antenna and radio-frequency (RF) chain costs of conventional active arrays. The compact and low form-factor structure of the RCA makes it particularly appealing for devices with stringent size, weight, and power (SWAP) constraints. In this article, we provide an overview of RCA to reveal its promising capabilities in wireless networks, including its system modeling, practical implementation, and competitive advantages over existing techniques. We present a variety of RCA-enabled performance enhancements in terms of mechanical beamforming gain, path-loss reduction, fading mitigation, spatial multiplexing gain, interference suppression, and geometric gain. Furthermore, we elaborate on the design challenges of RCA as well as promising solutions, and discuss the key applications of RCA in wireless networks. Finally, numerical results are presented to verify the substantial capacity gains enabled by RCA-aided transmission in wireless networks.
arXiv:2605.30304v1 Announce Type: cross
Abstract: We develop a straightforward analytical framework for the propagation of spatial light modes through a turbulent atmosphere. Built upon the split-step approach with the mode-based optical field representation, it directly assesses how turbulence-induced phase fluctuations deplete the optical power in the original mode and re-distribute it into neighboring spatial modes. Importantly, this power transfer scales linearly with the propagation distance in a uniform channel, yielding a simple solution for arbitrary distances in the form of a matrix exponential. The transfer rate is determined by the spatial spectral overlap between the turbulence spectrum and the acceptance spectrum for a pair of interacting spatial modes. The model predicts the average power in each spatial mode and is exact when a single mode strongly dominates all others. Our predictions show reasonably good agreement with simulations up to medium-to-strong turbulence levels. The model also confirms the scalings with mode order previously known as empirical observations.
arXiv:2604.13410v2 Announce Type: replace-cross
Abstract: We study the problem of estimating the effect function for a continuous treatment, which maps each treatment value to a population-averaged outcome. A central challenge in this setting is confounding: treatment assignment often depends on covariates, creating selection bias that makes direct regression of the response on treatment unreliable. To address this issue, we propose a two-stage kernel ridge regression method. In the first stage, we learn a model for the response as a function of both treatment and covariates; in the second stage, we use this model to construct pseudo-outcomes that correct for distribution shift, and then fit a second model to estimate the treatment effect. Although the response varies with both treatment and covariates, the induced effect function obtained by averaging over covariates is typically much simpler, and our estimator adapts to this structure. Our optimal learning bounds are achieved without estimating the conditional treatment density, thereby bypassing a major bottleneck in existing methods. Furthermore, we introduce a fully data-driven model selection procedure that achieves provable adaptivity to both the unknown degree of overlap and the spectral decay of the underlying kernel.
arXiv:2605.00898v2 Announce Type: replace-cross
Abstract: Accurate forecasting of battery health indicators, including remaining capacity and lifetime, is of paramount importance for ensuring the reliability, safety, and operational efficiency of applications such as electric vehicles and large scale energy storage infrastructures. The result of the forecasting can be adopted to build an advanced monitoring mechanism for continuous checking batteries' health status to assist in the efficient real-time management of numerous applications. This research investigates the development and implementation of a Deep Learning (DL) model for the prediction of the future state and performance of industrial electrochemical energy storage systems. To address this challenge, we propose a dedicated computational framework that integrates advanced neural network architectures with large-scale training datasets, enabling precise modeling of batteries degradation dynamics and operational trends. The proposed approach provides a decision support mechanism for the optimal management of batteries facilitating both predictive maintenance and the efficient allocation of energy resources. Our findings highlight the potential of DL-based predictive modeling to significantly contribute to the advancement of sustainable and intelligent energy management systems.
arXiv:2605.07596v3 Announce Type: replace-cross
Abstract: Contrastive Representation Learning (CRL) has achieved strong empirical success in multiple machine learning disciplines, yet its theoretical sample complexity remains poorly understood. Existing analyses usually assume that input tuples are identically and independently distributed, an assumption violated in most practical settings where contrastive tuples are constructed from a finite pool of labeled data, inducing dependencies among tuples. While one recent work analyzed this learning setting using U-Statistics to estimate the population risk, the techniques used therein require the risk of each class to concentrate uniformly, making excess risk bounds scale in the order of $\rho_{\min}^{-{1}/{2}}$ where $\rho_{\min}$ denotes the probability of the rarest class. Such a dependency can be overly pessimistic in the extreme multiclass settings where there are many tail classes which contribute minimally to the overall population risk. Our contributions are two-fold. Firstly, we improve upon the previous work and prove a bound with a sample complexity of the same order as the number of classes $R$, regardless of the distribution over classes. Furthermore, we formulate a different estimator that captures the concentration of the risk \textit{across classes}, enabling sharper bounds in extreme multi-class learning scenarios, especially where class distributions are long-tailed. Under mild assumptions on the class distributions, the resulting sample complexity is $\mathcal{{O}}(k)$ where $k$ is the number of samples per tuple.
arXiv:2605.12208v2 Announce Type: replace-cross
Abstract: Approximate Bayesian inference typically revolves around computing the posterior parameter distribution. In practice, however, the main object of interest is often a model's predictions rather than its parameters. In this work, we propose to bypass the parameter posterior and focus directly on approximating the posterior predictive distribution. We achieve this by drawing inspiration from self-training within self-supervised and semi-supervised learning. Essentially, we quantify a Bayesian model's predictive uncertainty by refitting on self-predicted data. The idea is strikingly simple: If a model assigns high likelihood to self-predicted data, these predictions are of low uncertainty, and vice versa. This yields a deterministic, sampling-free approximation of the posterior predictive. The modular structure of our Self-Supervised Laplace Approximation (SSLA) further allows us to plug in different prior specifications, enabling classical Bayesian sensitivity (w.r.t. prior choice) analysis. In order to bypass expensive refitting, we further introduce an approximate version of SSLA, called ASSLA. We study (A)SSLA both theoretically and empirically in regression models ranging from Bayesian linear models to Bayesian neural networks. Across a wide array of regression tasks with simulated and real-world datasets, our methods outperform classical Laplace approximations in predictive calibration while remaining computationally efficient.
arXiv:2605.26255v2 Announce Type: replace-cross
Abstract: Early prediction of respiratory failure is critical for timely clinical intervention in intensive care units. Existing electronic health record (EHR)-based models can continuously monitor physiologic deterioration, but they may not fully capture pulmonary pathophysiology reflected in chest radiographs (CXRs). In this study, we ask whether CXR information improves prospective prediction of invasive mechanical ventilation beyond EHR signals alone. We develop a gated multimodal framework that integrates structured EHR time-series data with CXR foundation-model representations. The gating module adaptively controls the contribution of imaging features based on patient-specific clinical context, allowing the model to selectively rely on imaging information when it is informative. We prospectively evaluate the framework for predicting invasive mechanical ventilation within 24 hours in ICU patients and compare it with an established EHR-only model (Ventio), physician predictions obtained at matched clinical time points, and alternative multimodal variants. The gated multimodal models achieved higher discrimination than the EHR-only baseline, with AUROC values of 0.860 and 0.858 using REMEDIS and MedInsight CXR representations, respectively, compared with 0.752 for Ventio. Relative to physician predictions, the multimodal framework substantially improved sensitivity while maintaining favorable specificity. Compared with the EHR-only model, multimodal integration increased specificity and positive predictive value, suggesting that CXR information can refine risk estimation in selected patients. These findings support adaptive multimodal fusion as a practical strategy for incorporating imaging into prospective respiratory failure prediction.
arXiv:2605.28327v2 Announce Type: replace-cross
Abstract: Traditional insurance pricing relies on risk-based principles that ensure actuarial fairness and solvency but do not explicitly account for policyholders' price sensitivity. We formulate insurance pricing as a decision-making problem and study it using tools from off-policy evaluation and stochastic control. We propose a kernelized inverse propensity score estimator that exploits local structure in the action space and yields variance reduction compared to the classical inverse propensity score estimator. Building on these value estimates, we investigate policy optimization and present two practical approaches for computing optimal pricing rules: an interpretable data-shared Lasso formulation and a flexible policy parameterization based on neural networks. Using a controlled synthetic travel insurance environment, we empirically confirm the theoretical results and show that neural networks outperform existing techniques for policy optimization.
arXiv:2512.24104v2 Announce Type: replace
Abstract: We investigate exceptional points of degeneracy (EPDs) in electromagnetic scattering of a sphere dimer from the electroquasistatic limit to the fully retarded regime. In the quasistatic limit, we prove that $\parity\trev$-symmetric configurations, realized by spheres with complex-conjugate susceptibilities, host EPDs. Beyond this limit, retardation breaks $\mathscr{PT}$-symmetry; nevertheless, by jointly tuning the material dispersion of the two spheres, we derive analytic synthesis conditions for realizing EPDs at \textit{real frequencies}. Near an EPD, we show that single-parameter perturbations yield the characteristic square-root splitting of the eigenfrequencies, and we quantify its impact on scattering, extinction, and absorption, clarifying sensing implications.
arXiv:2605.29829v1 Announce Type: new
Abstract: Leveraging Large Language Models (LLMs) to automatically formulate and solve optimization problems from natural language has emerged as an efficient paradigm for automated optimization. However, existing methods still exhibit limited generalization: they are sensitive to superficial narrative variations, reuse experience mainly at the case level, and struggle to adapt to shifted or emerging problem types. We propose OptSkills, an archetype-centric skill learning and reasoning agent system for optimization modeling and solving. To improve robust generalization, our system clusters problems by their underlying archetypes rather than surface narratives. To improve in-distribution generalization, it explores diverse modeling paradigms and solver configurations within each cluster, then distills successful trajectories into reusable workflow-level skills. To improve out-of-distribution generalization, it refines existing skills or expands the skill library using newly obtained trajectories. Our system achieves a state-of-the-art micro-averaged accuracy of 68.27% on datasets encompassing diverse problem types and scenarios. In addition, on MIPLIB-NL, a highly challenging large-scale and high-dimensional benchmark, it achieves 26.91% accuracy, outperforming DeepSeek-V3.2-Thinking by 4.53%. After skill learning on Nano-CO, it reaches 72.79% on the OOD NLCO benchmark. Code and skills are available at https://github.com/fujiwaranoM0kou/OptSkills.
arXiv:2605.29827v1 Announce Type: new
Abstract: Medical image analysis models can exhibit performance disparities across patient subgroups, threatening clinical safety and fairness. Existing methods typically address this issue by optimizing accuracy and fairness metrics for visible demographic attributes (e.g., sex or age) considered in isolation. This strategy not only overlooks potentially more informative latent stratifications, which may reveal deeper sources of model error and inequity, but also fails to scale when multiple demographic attributes are considered simultaneously due to the resulting sparsity of training data within each subgroup. We deal with these issues by introducing the label-free hidden-cohort fairness (LHCF) training paradigm that instead of maximizing fairness over visible demographic attributes, it optimizes fairness across latent subpopulations discovered from image appearance. By clustering images into K appearance-based cohorts and applying fairness optimization over them, LHCF uncovers underlying sources of model error and avoids the combinatorial sparsity of multi-demographic attributes, reducing disparities across both single and multiple demographic attributes. We demonstrate on our proposed fairness benchmark, HIDFairBench, that LHCF provides state-of-the-art fairness results on single and multiple demographic attributes, despite never using demographic labels for training. Our results position hidden-cohort fairness as a practical, scalable, and robust alternative to demographic-based fairness optimization for trustworthy medical image analysis.
arXiv:2511.19316v2 Announce Type: replace
Abstract: Recent fine-tuning techniques for diffusion models enable them to reproduce specific image sets, such as particular faces or artistic styles, but also introduce copyright and security risks. Dataset watermarking has been proposed to ensure traceability by embedding imperceptible watermarks into training images, which remain detectable in outputs even after fine-tuning. However, current methods lack a unified evaluation framework. To address this, this paper establishes a general threat model and introduces a comprehensive evaluation framework encompassing Universality, Transmissibility, and Robustness. Experiments show that existing methods perform well in universality and transmissibility, and exhibit some robustness against common image processing operations, yet still fall short under real-world threat scenarios. To reveal these vulnerabilities, the paper further proposes a practical watermark removal method that fully eliminates dataset watermarks without affecting fine-tuning, highlighting a key challenge for future research.
arXiv:2509.23573v5 Announce Type: replace
Abstract: Large language models (LLMs) are increasingly used to help security analysts manage the surge of cyber threats, automating tasks from vulnerability assessment to incident response. Yet in operational CTI workflows, reliability gaps remain substantial. Existing explanations often point to generic model issues (e.g., hallucination), but we argue the dominant bottleneck is the threat landscape itself: CTI is heterogeneous, volatile, and fragmented. Under these conditions, evidence is intertwined, crowdsourced, and temporally unstable, which are properties that standard LLM-based studies rarely capture.
In this paper, we present a comprehensive empirical study of LLM vulnerabilities in CTI reasoning. We introduce a human-in-the-loop categorization framework that robustly labels failure modes across the CTI lifecycle, avoiding the brittleness of automated "LLM-as-a-judge" pipelines. We identify three domain-specific cognitive failures: spurious correlations from superficial metadata, contradictory knowledge from conflicting sources, and constrained generalization to emerging threats. We validate these mechanisms via causal interventions and show that targeted defenses reduce failure rates significantly. Together, these results offer a concrete roadmap for building resilient, domain-aware CTI agents.
arXiv:2605.30281v1 Announce Type: new
Abstract: Skipper Charge-Coupled Devices (Skipper-CCDs) are a leading technology in the search for sub-GeV dark matter and coherent elastic neutrino-nucleus scattering. A key background for rare-event searches with these detectors arises from "spurious charge" -- single-electron events generated when charges are transferred through the active region to the serial register, and across the serial register to the readout stage. We present a characterization of spurious charge in both the active region and the serial register of SENSEI Skipper-CCDs, and show that, in a well-shielded low-background environment, the dominant contribution originates in the serial register during Skipper readout, when horizontal clocks are held at constant voltage between pixel transfers. Motivated by this finding, we develop a "tri-level" clocking scheme in which the held-low phase is raised to an intermediate voltage during readout to suppress trap-mediated charge generation. Using the SENSEI detector near the MINOS cavern, we measure a serial-register single-electron density of $(2.9 \pm 0.1) \times 10^{-5}$ electrons/pixel/image under standard SENSEI readout conditions, reduced to $(4.0 \pm 0.4) \times 10^{-6}$ electrons/pixel/image with tri-level clocking -- a factor of $\sim$7 improvement. This technique offers a promising path to lower backgrounds in current and future Skipper-CCD experiments.
arXiv:2605.30275v1 Announce Type: new
Abstract: Earlier detection of pancreatic cancer is key to enabling wider access to curative treatment and reducing cancer deaths; however, screening is presently not viable. Latent indicators of pathology are evident in an individual's disease and blood test trajectories and may predict the development of pancreatic cancer. Longitudinal sequences of coded diagnoses and blood test values accrued by patients throughout their clinical interactions were used to train a custom Transformer-based neural network with a multi-head attention mechanism to predict risk of pancreatic cancer with a multi-year lead time and risk-stratify populations for targeted screening. The cohort comprised 6,017 adults with pancreatic cancer and 177,081 controls (overall median age 75, 45% female) with median 12 years (interquartile range 6.9-16.2) of medical history prior to pancreatic cancer diagnosis. External validation via leave-one-site-out, out-of-sample testing predicting pancreatic cancer 1-, 2-, and 3-years prior to diagnosis demonstrated mean area under the receiver operating characteristic of 0.837 (95% confidence interval 0.827-0.848), 0.797 (95% confidence interval 0.782-0.813), and 0.760 (95% confidence interval 0.745-0.776), respectively. Estimated pancreatic cancer risks were well-calibrated (calibration plot slope 1.08, intercept of -0.077; Brier score 0.025), and a Bayesian population pancreatic cancer prevalence update allows estimated cancer risk outputs to be transportable across settings. At testing, a screening threshold of >3.3% risk of pancreatic cancer in 1-year offered a diagnostic odds ratio of 18.2. Our work therefore lays the foundation for a first population-level digital enrichment tool to widen access to curative-intent management of pancreatic cancer.