It’s self on self. What a war cry when it is me I crucify. Victor and vanquished are both me. Plumb the depths to send up a plea to me the receiver most high.
Science Journals
Cardiovascular-kidney-metabolic (CKM) syndrome was linked to cancer risk in a recent study, with increased risk as illness progressed.
In Reply We are grateful to Dr Leiva-Murillo for his commentary regarding our Review of IgAN in adults. Leiva-Murillo’s concern relates to a sentence in the abstract that states that “[u]p to 50% of patients with IgAN develop kidney failure within 10 years of diagnosis.” The evidence base for this statement is provided in the prognosis section: “Among 2299 adults with biopsy-proven IgAN included in a national registry–based study in the UK, 50% developed the composite outcome of death, kidney failure, or an eGFR less than 15 mL/min/1.73 m2 at a median (IQR) of 10.8 (10.0-12.0) years after diagnosis.”
This Review summarizes current evidence regarding the diagnosis and treatment of amyotrophic lateral sclerosis.
This randomized trial assesses the effect of intravenous tirofiban vs placebo on 90-day outcome among patients with acute ischemic stroke and an inadequate clinical response to intravenous tenecteplase.
This study evaluated whether adjunctive intravenous tirofiban improves functional outcomes in patients with acute ischemic stroke without large or medium vessel occlusion or a cardioembolic etiology who show inadequate response to tenecteplase.
To the Editor A recent article provided a clear and clinically useful overview of post–intensive care syndrome (PICS), emphasizing physical, cognitive, and psychological sequelae; early screening; and multidisciplinary follow-up. However, we contend that the proposed framework of PICS underrepresents spiritual distress and bereavement—domains that may meaningfully shape recovery trajectories for both patients and families after critical illness. As PICS is framed as a conceptual construct rather than a diagnosis, we believe there is an opportunity to broaden its scope to intentionally include spiritual and bereavement-related dimensions that shape recovery and long-term well-being.
To the Editor A recent article on PICS provided an excellent synthesis of the cognitive and emotional difficulties experienced by ICU survivors.
In Reply I agree with Dr Byrne-Martelli and colleagues that addressing spiritual distress and bereavement is essential to providing truly holistic care for survivors of critical illness and their families. Although PICS is classically defined as new or worsening impairments in physical, cognitive, or mental health status persisting beyond hospitalization, highlighted in my Insights article, its scope remains debated. Although some contend that the current syndrome-based definition is overly broad, others think it should expand to include impairments in social health and quality of life—domains that encompass spiritual well-being and identity reconstruction. This tension underscores the challenge of defining PICS in a way that is both clinically rigorous and reflects survivors’ lived experiences.
This JAMA Patient Page describes common symptoms and causes of benign paroxysmal positional vertigo, risk factors, and diagnosis and treatment.
To the Editor We read with great interest the Review article on gastric cancerand would like to address 2 key points regarding the treatment and risk factors for gastric cancer.
To the Editor The recent Review on IgA nephropathy (IgAN) in adults provided an excellent summary of key aspects of the disease. However, a statement in the Abstract could lead to an overly uniform prognostic interpretation and warrants clarification.
In this narrative medicine essay, a retired family physician muses over the predigital tools he collected to help him meet his patients’ health challenges and reflects on how much medicine was integrated into his own life.
Prescribing of nonstatin lipid-lowering therapies has increased in the US, but nonstatins still represent a small share of low-density lipoprotein cholesterol (LDL-C)–lowering treatments, according to a national prescription database study published in JAMA Cardiology.
A new study found that older adults may experience cognitive decline up to 8 years before a cardiovascular event, potentially offering an early warning signal.
This Viewpoint discusses how restructuring the Health Resources and Services Administration (HRSA) could affect access to health care in underserved areas by disrupting international medical graduates’ ability to obtain J-1 visa waivers.
Graduate medical education looks very different in 2026 than it did in the early 1800s, with the many changes since that time including formalization and funding for teaching hospitals, efforts at work-hour limitations, and an emphasis on competency-based education. Yet, given the demands of the profession, graduate medical education remains a very challenging training—cognitively, physically, and emotionally.
This randomized trial assesses the effect of a parental support package targeting perinatal stressors on occupational burnout among pregnant physicians in training.
This Perspective discusses prevention of pregnancy-related cardiovascular morbidity and mortality before, during, after, and between pregnancies.
When I doctor sometimes I read about psychedelics and long to dissolve the boundaries of self when I palpate a pulse first my patient’s then the faint rhythm in my own fingertips and, just briefly, let them play one music indecipherable
Use of alternative medicines has increased among US children, a study recently published in Pediatrics Open Science suggests.
This randomized clinical trial compares the effects of adjunctive intra-arterial alteplase after successful thrombectomy vs thrombectomy alone on functional outcomes and cerebral reperfusion.
The study evaluated whether adjunctive intra-arterial alteplase given after successful thrombectomy improves functional recovery and tissue perfusion in patients with acute ischemic stroke caused by large vessel occlusion.
This Viewpoint discusses how overreliance on artificial intelligence (AI) can lead to deskilling and mis-skilling among clinicians still in training and the importance of thoughtful design and implementation into the clinical learning environment.
The rapid increase in use of ambient scribes and the potential implications for clinical practice are the focus of this installment of the Healthy Dialogue podcast, featuring JAMA Senior Editor Derek C. Angus, MD, MPH, and Vincent X. Liu, MD, MS, chief data officer of The Permanente Medical Group at Kaiser Permanente.