Forskningsradar

Science Journals

Peer-reviewade publikationer — 51236 artiklar

Excessive epithelial mechanosensation drives nociceptive innervation and chronic bladder pain via the PIEZO1-SLC7A11-glutamate axis
<p>Publication date: Available online 26 June 2026</p><p><b>Source:</b> Cell</p><p>Author(s): Min Jung Kim, Joo Hwan Noh, Ho Young Lee, Bohm Lee, Alexander Doh Park, Hyeonseo Oh, Geun-Woo D. Kim, Hye-Sook Lee, Yeonsoo Oh, Hyeonje Hwang, Chungoo Kim, Hyeonjong Lee, Xue Li, Mi Mi Oh, Donghoon Lim, Soman N. Abraham, Yongcheol Cho, Sung Wook Chi, Hae Woong Choi</p>
Shared neural geometries for bilingual semantic representations in human hippocampal neurons
<p>Publication date: Available online 24 June 2026</p><p><b>Source:</b> Cell</p><p>Author(s): Xinyuan Yan, Ana G. Chavez, Melissa Franch, Kalman A. Katlowitz, Ivy Gautam, Brian Kim, Aaditya Krishna, Aadit Shrivastava, Katie Van Arsdel, James Belanger, Assia Chericoni, Taha Ismail, Elizabeth A. Mickiewicz, Danika Paulo, Hanlin Zhu, Alica M. Goldman, Vaishnav Krishnan, Atul Maheshwari, Eleonora Bartoli, Nicole R. Provenza</p>
Systematic discovery of pathogen effector functions across human pathogens and pathways
<p>Publication date: Available online 30 June 2026</p><p><b>Source:</b> Cell</p><p>Author(s): Tomas Pachano, He Leng, Guillaume Dugied, Travis Tribble, Vincent Loubiere, Yeojin Lee, Felix Rauh, Victor Manon, Kevin Yuan, Jocelyn Nurtanto, Alexander Schleiffer, Veronika Young, Benjamin Weller, Eleanor A. Lyons, Matthew R. Hass, Leah C. Kottyan, Matthew T. Weirauch, Juan I. Fuxman Bass, Hayley J. Newton, Alexander W. Ensminger</p>
AI-driven discovery of GPNMB CAR T cells as a multi-cancer therapy
<p>Publication date: 25 June 2026</p><p><b>Source:</b> Cell, Volume 189, Issue 13</p><p>Author(s): Daniel J. Baker, Leon M. Frommer, Ugur Uslu, Kisha K. Patel, Daniel Zhu, Nils W. Engel, James M. George, Wencao Zhao, Samuel I. Kim, Lisa Sun, Christopher Roselle, Philipp C. Rommel, Regina M. Young, Jonathan A. Epstein, Sikander Hayat, Zoltan Arany, Carl H. June</p>
A phase II peri-operative study of pembrolizumab plus lenvatinib for mucosal melanoma
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73190-1Mucosal melanoma is a rare and aggressive subtype which, unlike cutaneous melanoma, shows limited response to immune checkpoint inhibition. Here, the authors report the safety and efficacy of neoadjuvant pembrolizumab (anti-PD-1) and lenvatinib (multi tyrosine kinase inhibition) in patients with resectable mucosal melanoma, along with exploratory biomarker analysis.
Catalytic Markovnikov hydrophosphorylation of unactivated olefins via a radical-polar crossover rearrangement
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-72870-2Organophosphoryl compounds are important motifs, however regioselective phosphorylation of alkenes remains challenging. Here, the authors report a visible light driven triple catalytic strategy enabling radical Markovnikov hydrophosphorylation of unactivated alkenes via sequential reaction of (bis)homoallylic alcohols, Ph₂PCl, and water.
Visualization of the complete preprimosome reveals the structural mechanisms governing DNA replication restart
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73239-1Restart of failed DNA replication processes is essential but poorly understood. Here, the authors present cryoEM structures of two preprimosome complexes, revealing how the PriA/PriB/DnaT complex assembles and matures. The findings suggest a possible DnaA-like mechanism for replisome recruitment.
Robust intensification of projected regional precipitation extremes over Africa
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73246-2Extreme rainfall will intensify across Africa under future warming, with the largest increases expected in equatorial regions. This intensification is driven primarily by increased atmospheric moisture associated with radiation-induced warming.
De novo design of peptides localizing at the interface of biomolecular condensates
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73099-9Combining high-throughput molecular simulations, machine learning, and mixed-integer linear programming, the authors design peptides that localize to condensate interfaces, revealing surfactant-like, charge-dependent sequence rules.
Keratins coordinate tissue spreading by balancing spreading forces with tissue material properties
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-72366-zThe contrasting roles of epithelial tissues in providing flexibility while maintaining integrity are not yet well understood. Here, the authors show that this need can be fulfilled by keratin intermediate filaments cross talking to other cytoskeletal machinery across the developing epithelium.
Protein-based pan-RAS inhibitor induces tumor regression in female mice via IFNγ and CD8<sup>+</sup> T cell-dependent tumor necrosis
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73300-zMany cancers depend on RAS signaling, but blocking diverse RAS mutants remains challenging. Here, authors engineer a protein-based pan-RAS inhibitor that induces tumor regression in mouse models and reveals an immune-dependent mechanism of action