For people with certain apolipoprotein E (APOE) genotypes at increased risk of Alzheimer disease, higher meat consumption may be associated with reduced cognitive decline, a study of a cohort in Sweden found.
Science Journals
This Medical News article discusses the potential for the antidepressant mirtazapine to treat methamphetamine use disorder.
JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, spoke with Viktor H. Ahlqvist, PhD, a postdoctoral fellow in the Unit of Integrative Epidemiology of the Institute of Environmental Medicine at Karolinska Institutet, for JAMA+ AI Conversations.
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, with an estimated 150 000 new cases annually worldwide. Patients with DLBCL typically require treatment at the time of diagnosis, and more than 60% of patients are currently cured with front-line immunochemotherapy such as R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). However, DLBCL is highly heterogeneous, and subsets of patients who progress after front-line treatment have a substantially poorer clinical outcome. Therapeutic progress to improve the outcome of the patients with lymphoma destined to progress after initial chemotherapy has proven very difficult, with very few trials showing superiority of an experimental group over standard R-CHOP.
This study uses data from the National Vital Statistics System to examine quarterly suicide mortality among individuals aged 15 to 34 years.
This randomized clinical trial conducted in China evaluates the efficacy and safety of the histone deacetylase inhibitor tucidinostat plus R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) vs R-CHOP alone as first-line treatment for patients with MYC/BCL2 double-expressor lymphoma.
This study aimed to assess whether adding the histone deacetylase inhibitor tucidinostat to rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) improves clinical outcomes in patients with newly diagnosed MYC/BCL2 double-expressor lymphoma.
This study analyzes US state actions taken in 2025 that strengthened or weakened COVID-19 vaccination infrastructure and access.
This Review summarizes the current evidence for prepregnancy care and counseling with a primary care focus.
Naming is essential in medicine. Medical terminology allows clinicians to document and communicate and, most importantly, make diagnoses. A feeling of control can come from arriving at that perfect word that unifies each of a patient’s specific medical findings. However, even the most skilled clinician may still be left speechless when confronting the enormity of at once obvious, and yet unspeakable, mortality. The esteemed poet W. H. Auden famously asserted, “…poetry makes nothing happen” in his 1939 poem “In Memory of W. B. Yeats.” “On Mortality” reminds us of the same insufficiency of language, not just medical language but even poetry, as the speaker grasps at the right words to describe the end of life. The chastened clinician relies on found objects and simple observations to convey what even the most astute diagnosis cannot. As moving as these are—the back massage never received, the routinization of intensive care unit deaths—by the last stanza, the speaker finally relinquishes the attempt to explain mortality, surrendering to the realization that “too many words” only defeat such efforts. This ironically lapidary poem offers an interesting reflection for clinicians—what do we say when we feel but cannot fully describe something we witness? Thus poetry, with its comfort with silences and concision, arises in addition to medical vernacular. Poetry, by eliciting pure feeling, can allow the reader to experience awe at the human condition when accurate diagnosis, or even just the right word, seems elusive.
This Viewpoint discusses the chasm between current US health care and a vision of more comprehensive, equitable, and patient-centered care and proposes actionable strategies to bridge that chasm.
This Perspective discusses the use of bayesian methods in clinical trials and the importance of having US Food and Drug Administration (FDA) guidance that provides substantive insights about the methods’ proper role.
This Perspective discusses the draft guidance for industry that the US Food and Drug Administration released on the use of bayesian methods in testing therapeutics.
This JAMA Clinical Guidelines Synopsis summarizes the 2024 recommendations from the American Heart Association and American College of Cardiology on perioperative cardiovascular medication management for noncardiac surgery.
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
This JAMA Patient Page describes metabolic dysfunction–associated steatotic liver disease (MASLD) and its risk factors, symptoms and complications, diagnosis, and treatment.
Isogenic cells can break symmetry and adopt different fates, even when exposed to a seemingly identical environment. This deeply conserved phenomenon allows unicellular organisms to pre-empt dynamically changing environments and is central to the evolution of multicellularity. It is thought that cells are primed towards different lineages by cell-cell variation, although the underlying mechanisms are poorly understood. To address this, we exploit the tractability of the social amoeba <i>Dictyostelium discoideum</i>, where cell fate choice also does not depend on spatial cues. We develop and test a model to explain quantitative experimental single-cell observations of probabilistic differentiation. The model suggests that cell cycle position affects lineage choice, as previously shown but that stochastic cell-cell variation also plays a key role. Single cell sequencing reveals genes that exhibit cell type-specific expression or genes that affect fate choice exhibit extensive stochastic cell-cell expression variation. Like lineage priming genes in ESCs, they are associated with H3K4 methylation, which when perturbed affects their expression and disrupt fate choice. We suggest the integration of stochastic and deterministic inputs represents an adaptive mechanism to increase developmental robustness against perturbations that affect deterministic signals.
JAMA Senior Editor Derek C. Angus, MD, MPH, spoke with Dost Öngür, MD, PhD, JAMA Psychiatry Editor, and Jeremy Veenstra-VanderWeele, MD, a professor of developmental neuropsychiatry at Columbia University, about autism spectrum disorder for the Healthy Dialogue podcast.
To the Editor A recent study that used a propensity score and 1:3 matching provided valuable insight into the potential effect of glucagon-like peptide 1 receptor agonists (GLP-1RAs) during pregnancy. Nevertheless, several limitations warrant careful consideration.
To the Editor A recent study examining gestational weight gain and pregnancy outcomes after discontinuation of GLP-1RAs before conception provided timely evidence in a rapidly evolving therapeutic landscape. However, several methodological and clinical aspects warrant clarification to avoid premature conclusions regarding safety.
This retrospective cohort study examines treatment failure and adverse events in standard-dose amoxicillin compared with amoxicillin-clavulanate in adults with acute sinusitis.
Ray Lyman Wilbur, M.D., Stanford University, Calif.
To the Editor We write in response to a recent Viewpoint, which contained false statements and misunderstandings about restorative reproductive medicine (RRM) that need to be corrected.
In Reply We appreciate the Letter from Dr Minjeur and colleagues regarding our Viewpoint, as well as the opportunity for clarifications.
Cleaning out her bedside stand unused back-rub gift certificates.