arXiv:2605.15774v1 Announce Type: new
Abstract: Traditional Fully Homomorphic Encryption (FHE) schemes often suffer from prohibitive computational overhead and complex noise management. In this paper, we propose a novel symmetric FHE through a mechanism of plaintext fragmentation and dynamic interposition. Our approach is built upon a modular encryption foundation, c = mk + rp, which is naturally additive but typically limited by exponential noise growth during multiplication. To resolve this, we introduce an interposition framework where the plaintext is partitioned into multiple fragments across distinct logical positions. We introduce a dual-regulator system to govern the multiplication process; exponent regulators (t_i) redirect the product of fragments to a new target position, preventing the accumulation of secret key exponents, while coefficient regulators (d_i) normalize the resulting scalars. Security is established through a binding mechanism where exponents and coefficients are mutually dependent, shielding the secret key k from algebraic manipulation and substitution attacks.
Science Journals
arXiv:2605.15475v1 Announce Type: new
Abstract: We introduce an empowered transposed Fully Connected Weighted (t-FCW) graph representation to embed point clouds into a metric space. While original t-FCW has shown promising results for point cloud classification, the reasons behind its effectiveness and its broader applicability remained unclear. In this work, we analyze the properties that make the empowered and original t-FCW effective and design a network that uses the empowered t-FCW exclusively as feature extractors. From an interpretability perspective, we build memory banks for classification, part segmentation, and semantic segmentation using the empowered t-FCW. Our analysis reveals that the empowered t-FCW inherits robustness from surface descriptors, provides interpretability through dimension-wise relations. These properties enable a highly efficient and interpretable network, which processes the ModelNet40 classification problem in approximately 7 seconds on an NVIDIA RTX A5000 GPU. Importantly, empowered t-FCW can function both as a lightweight standalone baseline and as a complementary plug-in to existing deep models.
arXiv:2605.15640v1 Announce Type: new
Abstract: Multi-View Clustering (MVC) has gained significant attention for its ability to leverage complementary information across diverse views. However, existing deep MVC methods often struggle with view-distribution entanglement during cross-view fusion, which hampers the quality of the shared latent space and leads to suboptimal Figures. To address this issue, we propose the Generalized Multi-view Auto-Encoder (GMAE), a framework designed to preserve cross-view complementarity through disentangled representation learning. Specifically, GMAE employs dual-path autoencoders to decouple source features into view-specific and view-common embeddings, facilitating the discovery of clearer clustering structures. We further construct cross-view adversarial discriminators to guide view-specific encoders in capturing more discriminative features. By strategically modulating mutual information, GMAE effectively aligns distributions and prevents representation collapse, ensuring the generation of robust, non-trivial embeddings. Comprehensive experiments on 13 benchmark datasets demonstrate that GMAE consistently outperforms state-of-the-art methods in both complete and incomplete MVC tasks. Our code implementation is available at the repository: https://github.com/obananas/GMAE.
arXiv:2605.15761v1 Announce Type: new
Abstract: Evaluation leaderboards such as LMArena play a central role in benchmarking large language models by aggregating pairwise human preferences into model rankings, yet the robustness of these rankings remains poorly understood. We present a unified perturbation framework for analyzing Bradley-Terry leaderboards under structured data modifications using influence-based approximations. Our framework studies three match-level perturbations -- Drop, Add, and Flip -- together with player removal, and evaluates their effects on top-k membership, global ranking consistency via Kendall's tau, and confidence-interval-based uncertainty. Across Chatbot Arena and six additional pairwise-comparison datasets, we show that modern leaderboards are non-robust across all three objectives: sub-1% targeted perturbations can change the top-ranked model, degrade Kendall's tau, and alter confidence intervals. Beyond robustness auditing, we show that the same influence scores enable efficient targeted perturbations, promoting or demoting specific models and reducing target-model uncertainty with fewer actions than previous manipulation and active-sampling baselines. By summarizing these effects with normalized dataset-level robustness scores, our framework provides a practical and helpful tool for auditing leaderboard stability and motivating more robust evaluation protocols.
arXiv:2605.15575v1 Announce Type: new
Abstract: Relational graph learning models relational databases as graphs and has demonstrated superior performance on a wide range of relational predictive tasks. However, existing methods struggle to capture long-range dependencies due to information decay in their message-passing mechanisms, and recent relational graph transformers remain limited in jointly modeling structural, semantic, and temporal information. In this paper, we propose GelGT, a Gaussian relational graph transformer that explicitly addresses these challenges. GelGT introduces a structure-semantic collaborative sampling strategy to preserve structural connectivity while filtering irrelevant semantic information, and incorporates a Gaussian graph attention mechanism with a learnable Gaussian bias on the sampled subgraphs to dynamically encode temporal dependencies. Extensive experiments on various real-world datasets demonstrate that GelGT achieves state-of-the-art downstream task performance, with up to a 13.8% improvement in predictive performance.
arXiv:2510.22665v3 Announce Type: replace
Abstract: Synthetic Aperture Radar (SAR) is a critical imaging modality due to its all-weather operational capability. Although recent advances in self-supervised learning and masked image modeling (MIM) have enabled SAR foundation models, these approaches primarily focus on low-level visual features and often neglect multi-modal representation. Moreover, multimodal data for SAR is scarce, limiting the development of robust cross-modal models. To address this limitation, we construct SARVLM-1M, a large-scale vision-language dataset comprising over one million image-text pairs aggregated from existing datasets. Furthermore, to mitigate the substantial differences between SAR and natural imagery, we propose a two-stage domain transfer training strategy that leverages optical remote sensing data as an intermediate bridge, facilitating effective knowledge transfer from natural images to SAR domains. Based on this strategy, we develop SARVLM, the first vision-language foundation model tailored for SAR, consisting of SARCLIP and SARCap. In addition, an ensemble strategy is utilized to improve the cross-scene generalization capability of the model. Moreover, SARDet and SARRot further validate the capability of the proposed framework in object detection. Extensive experiments on 13 benchmarks across image-text retrieval, target recognition, zero-shot classification, object detection, semantic localization, and image captioning demonstrate the superior feature extraction and interpretation capabilities of SARVLM. It consistently outperforms state-of-the-art vision-language models and advances semantic understanding in SAR imagery. Code and datasets will be released on https://github.com/KlayMa527/SARVLM.git.
arXiv:2505.21698v3 Announce Type: replace
Abstract: Vision-language foundation models achieve promising performance in natural image classification, yet their direct application to medical imaging is limited by severe domain shifts, resolution mismatches, and the multi-label nature of clinical diagnosis. Training dedicated medical foundation models from scratch, however, is costly and data-intensive. Here, we propose MedBridge, a lightweight adaptation framework that opens a new direction in domain-gap mitigation by jointly combining domain alignment, resolution preservation, and multi-label reasoning via complementary VLM experts for medical image diagnosis. Specifically, MedBridge transforms pretrained VLMs into multi-view query encoders that inject a compact set of learnable query tokens into intermediate layers, enabling non-destructive domain alignment while preserving fine-grained pathological cues via multi-view high-resolution sampling. These query tokens further act as routing signals for a mixture-of-experts, dynamically integrating heterogeneous foundation models for multi-label reasoning without requiring a shared representation space. We evaluated MedBridge on five chest radiograph benchmarks in three key adaptation tasks. MedBridge demonstrates superior performance in both cross-domain generalization (out-of-distribution transfer) and in-domain specialization (same-distribution tuning) settings, yielding a significant 6-15% AUC improvement over state-of-the-art adaptation methods for multi-label thoracic disease diagnosis. Furthermore, MedBridge is model-agnostic and demonstrates broad extensibility across eight diverse VLMs (e.g., CLIP, LLaVA, Qwen-VL, MedGemma), highlighting its ability to flexibly adapt arbitrary foundation models into a powerful medical diagnostic tool. Our code will be released upon acceptance.
arXiv:2605.15582v1 Announce Type: new
Abstract: Modern deep learning models for change detection (CD) often struggle to explicitly represent task-relevant semantic differences. This paper proposes the Latent Difference Guidance (LDGuid) framework that explicitly learns and injects semantic differences into CD models. LDGuid deploys adversarial autoencoding to implement a difference embedding (DE) module. The DE module is pretrained via the information bottleneck method, restricting it to learn only task-relevant differences between pre- and post-event samples. The learned latent difference is then used as an explicit guidance signal in the CD model. We validate LDGuid by integrating it into U-Net, BIT, and AERNet baselines for CD and evaluating it on LEVIR-CD, WHU-CD, SVCD, and CaBuAr datasets. Experimental results show that LDGuid enhances segmentation performance across all benchmarks, with particularly remarkable gains in challenging settings affected by spectral noise. The results further highlight the ability of LDGuid in incorporating domain knowledge, such as task-specific spectral indices. Our findings suggest that semantic difference learning can drastically enhance the robustness of CD in remote sensing.
arXiv:2605.15583v1 Announce Type: new
Abstract: We propose a method of estimating a 3D human pose from a single view without 3D supervision. The key to our method is to leverage the 2D diffusion priors of motion diffusion models (MDMs) pre-trained on large 2D human pose datasets. Specifically, we extend multi-view ancestral sampling of diffusion models to the task of 2D-3D lifting of human pose. To this end, we newly propose a conditional multi-view ancestral sampling (cMAS) that optimizes the 3D pose such that its multi-view projections follow the manifold in 2D MDM noise space, while conditioning the 3D pose to match the given 2D poses and anatomical constraints of humans. Experiments on the Yoga dataset demonstrate that our method achieves better cross-domain performance compared to state-of-the-art supervised and unsupervised 3D pose estimation methods, including extreme human poses where 3D supervision is unavailable. Code is available at: https://github.com/asaa0001/c-MAS.
arXiv:2604.22393v2 Announce Type: replace-cross
Abstract: Hexagonal diamond (HD), an exotic carbon allotrope recently synthesized in bulk form, exhibits superior mechanical properties compared to cubic diamond (CD) and holds promise for advanced industrial and quantum applications. Using first-principles calcu-lations, we systematically investigate intrinsic defects, extrinsic dopants, and defect complexes in HD. Our study shows that VC dominates intrinsic conductivity, while Ci is unstable. Among extrinsic dopants, boron acts as a benign acceptor enhancing p-type conductivity, whereas nitrogen and phosphorus serve as effective donors for n-type conductivity. Group II and Group IV dopants, however, introduce high formation energies or neutral charge states with limited impact. Furthermore, VC, MgC and XV defect com-plexes display multiple spin and charge states within the HD band gap, highlighting their potential as color centers for hosting qubits. These results not only clarify the defect physics of HD but also demonstrate its broader implications for conductivity engineering and quantum technologies.
arXiv:2605.15585v1 Announce Type: new
Abstract: Large language models can generate executable code for educational animations, but the resulting renders often exhibit visual defects, including element overlap, misalignment, and broken animation continuity. These defects cannot be reliably detected from the code alone and become apparent only after execution. We formalize this problem as render-feedback-aware constrained code generation: given a natural language specification, the model must generate executable code whose rendered output satisfies structured quality criteria that can be evaluated only after rendering. To address this problem, we introduce OmniManim, a render-feedback-aware educational animation generation framework built around a shared scene state, explicit visual planning, structured post-render diagnostics, and localized repair. Within OmniManim, the Vision Agent is a task-specific visual planning module: it predicts sparse keyframe layouts with coarse-to-fine bounding-box denoising and optimizes an interpolation-aware objective to reduce intermediate-frame failures induced by downstream animation interpolation. We further construct two datasets, ManimLayout-1K and EduRequire-500, and provide a reproducible evaluation protocol covering executability, instructional quality, visual quality, and efficiency. On EduRequire-500, OmniManim improves measured render quality over both single-model baselines and existing multi-agent frameworks. Systematic ablation studies further verify that explicit visual planning, especially its coarse spatial prior, bounding-box refinement, and interpolation-aware optimization, is central to these gains.
arXiv:2605.00424v2 Announce Type: replace
Abstract: Agent skills - structured packages of instructions, scripts, and references that augment a large language model (LLM) without modifying the model itself - have moved from convenience to first-class deployment artifact. The runtime that loads them inherits the same problem package managers and operating systems have always faced: a piece of content claims a behavior; the runtime must decide whether to believe it. We argue this paper's central thesis up front: a skill is untrusted code until it is verified, and the runtime that loads it must enforce that default rather than infer trust from a signature, a clearance, or a registry of origin. Without skill verification, a human-in-the-loop (HITL) gate must fire on every irreversible call - which is operationally untenable and degrades into rubber-stamping at any non-trivial scale. With skill verification treated as a separate, gated process, HITL fires only for what is unverified, and the system becomes sustainable. We give a trust schema that includes an explicit verification level on every skill manifest; a capability gate whose HITL policy is a function of that verification level; a biconditional correctness criterion that any candidate verification procedure must satisfy on an adversarial-ensemble exercise; and a portable runtime profile with ten normative guidelines abstracted from a working open-source reference implementation. The contribution is harness- and model-agnostic; nothing here requires retraining, fine-tuning, or proprietary infrastructure.
arXiv:2605.15765v1 Announce Type: new
Abstract: Optimization problems with drones are widely studied in a variety of civilian tasks, mainly due to their ability to traverse rough terrains and to carry cameras and other sensors for surveillance tasks. The limited battery life of these aerial robots poses challenges in operational research. In this paper, we address the following optimization problem. We are given a set of line segments (e.g. tubes in a solar plant) to inspect by drones. The objective is to detect broken pipes using artificial intelligence and path planning must be carried out efficiently. On the one hand, the limited capacity of the batteries necessitates periodic visits (tours) to a fixed base station. However, it is desirable to allocate a set of tours for each drone to ensure that the segments are covered as quickly as possible, aiming to minimize the makespan, which is the maximum time spent by any drone. We are able to prove that this optimization problem is strongly NP-hard even when the segments are positioned on a line and the scenario involves only two drones. Then, approximation algorithms are proposed. Our computational experiments demonstrate that the proposed algorithm achieves near-optimal performance across diverse operational scenarios.
arXiv:2605.15766v1 Announce Type: new
Abstract: Large language model (LLM) agents are increasingly capable of automating components of machine learning development, yet existing biomedical benchmarks mainly focus on question answering, reasoning, and tool usage, or evaluate only narrow aspects of biomedical ML coding. We present BioXArena, a biomedical machine learning benchmark designed to evaluate whether agents can generate task-specific model training pipelines for heterogeneous and multi-modal biomedical datasets. BioXArena contains 76 end-to-end tasks across 9 domains, including sequence modeling, single-cell analysis, structural biology, network biology, chemical biology, perturbation dynamics, phenotype-disease modeling, biomedical imaging, and text-integrated learning. Each task is curated from primary biomedical sources into a unified evaluation framework with hidden labels, held-out graders, and biology-aware metrics normalized to a 0 to 1 scale. Agents are required to write executable code, train predictive models, and generate submissions for private test samples. Most tasks involve multiple input modalities, including tabular data, images, natural language, molecular sequences, omics matrices, and protein structures. We evaluate 11 agent configurations in a standardized 2-hour single-GPU environment. MLEvolve with Gemini-3.1-Pro achieves the highest average score of 0.666, followed by GPT-5.4 with 0.636, while no single agent consistently dominates across all domains. We additionally perform extensive ablation studies, robustness evaluations, scaling analyses, cost analyses, and failure-mode investigations to better understand how model backbones, agent scaffolds, inference budgets, and biomedical domains influence BioML coding performance. We will publicly release all benchmark tasks, graders, execution runners, leaderboard results, and agent trajectories.
arXiv:2510.24165v2 Announce Type: replace
Abstract: Dynamic Epistemic Logic extends classical epistemic logic by modeling not only static knowledge but also its evolution through information updates. Among its various systems, Public Announcement Logic (PAL) provides one of the simplest and most studied frameworks for representing epistemic change. While the semantics of PAL is well understood as transformation of Kripke models, the proof theory so far developed fails to represent this dynamism in purely syntactical terms. In this paper we propose a step toward addressing this gap. In particular, building on a hypersequent calculus for S5, we extend it with a mechanism that models the transition between epistemic models induced by public announcements. We call these structures dynamic hypersequents. Using dynamic hypersequents, we construct a calculus for PAL and we show that it enjoys several desirable properties: admissibility of all structural rules (including contraction), invertibility of logical rules, as well as syntactic cut-elimination.
arXiv:2605.15597v1 Announce Type: new
Abstract: Modern 3D visual learning relies on observations sampled from metric 3D assets, yet existing scans, meshes, point clouds, simulations, and reconstructions do not directly provide a sparse, comparable, and geometry-consistent panoramic training interface. Dense trajectories duplicate nearby views, source-specific rendering policies yield heterogeneous annotations, and sparse heuristics may miss important regions or introduce depth-inconsistent observations. We study how to convert 3D assets into sparse panoramic RGB-D-pose data that preserves complete scene coverage with low redundancy and auditable provenance. We propose COVER (Coverage-Oriented Viewpoint curation with ERP Range-depth warping), a training-free ERP viewpoint curator that projects geometry observed from selected views into candidate ERP probes, scores incremental coverage, and penalizes depth conflicts. Under bounded proxy error, its greedy coverage proxy preserves the standard coverage-style approximation behavior up to an additive error term. Using COVER, we build CM-EVS (Coverage-curated Metric ERP View Set), a panoramic RGB-D-pose dataset with 36,373 curated ERP frames from 1,275 indoor scenes across Blender indoor, HM3D, and ScanNet++, complemented by outdoor panoramas from TartanGround and OB3D re-encoded into the same schema. Each frame provides full-sphere RGB, metric range depth, calibrated pose; COVER-produced indoor frames include per-step provenance logs. With a median of only 25 frames per indoor scene, CM-EVS covers all 13 unified room types while maintaining compact scene-level coverage. Experiments show that COVER improves the coverage-conflict trade-off, making CM-EVS a sparse, compact, and auditable RGB-D-pose resource for geometry-consistent panoramic 3D learning.
arXiv:2510.24457v2 Announce Type: replace
Abstract: This paper presents an optimal trajectory generation method for 3D overhead cranes by leveraging differential flatness. This framework enables the direct inclusion of complex physical and dynamic constraints, such as nonlinear friction and collision avoidance for both payload and rope. Our approach allows for aggressive movements by constraining payload swing only at the final point. A comparative simulation study validates our approach, demonstrating that neglecting dry friction leads to actuator saturation and collisions. The results show that friction modeling is a fundamental requirement for fast and safe crane trajectories.
arXiv:2604.26782v2 Announce Type: replace
Abstract: This paper develops a deep policy iteration method for high-dimensional finite-horizon mean-field games (MFG). We reformulate the game as a regenerative problem with deterministic cycles, which allows policy evaluation (PE), policy improvement (PI), and population measure estimation to be carried out cycle by cycle. Within this formulation, we approximate the population measure by a particle system and update it using a one-step random mapping induced by the Euler-Maruyama discretization of the state dynamics. This update transports a mini-batch of particles from one cycle to the next, avoiding sequential trajectory simulation over the entire time horizon at each iteration. The PE and PI subproblems are formulated through the relation between consecutive cycles, with adversarial training used for evaluation and averaged optimization used for improvement. The resulting method is efficient and scalable in high dimensions, as it avoids the direct solution of the coupled Hamilton-Jacobi-Bellman and Fokker-Planck system, the full simulation of trajectories to estimate the population measure, the explicit computation of conditional expectations in policy evaluation, and pointwise optimization in policy improvement. Numerical experiments demonstrate that the proposed method effectively handles dimensions up to 10,000.
arXiv:2605.15459v1 Announce Type: new
Abstract: The minima of modern neural network loss functions are typically not isolated, rather they form connected components of reparameterization invariant solutions on the training data. Analytically characterizing these solutions is a hard problem, but sampling approaches are feasible. By construction, existing methods either spread over low-loss regions, and thus do not sample reparameterization invariant solutions exactly, or are inherently local, which limits exploration of other minima valleys. We propose sampling such reparameterization invariant models using a dynamical system based on kinetic energy, subject to a gravitational pull and a friction term that dissipates energy from the system. Our proposed sampler, DiMS, is guaranteed to sample exactly from the minimum level sets and depends on physically motivated hyperparameters which allows control over the exploration capabilities of the sampler. We consider uncertainty quantification in Bayesian inference as the motivating problem and observe improved performance compared to previously proposed approaches.
arXiv:2605.15598v1 Announce Type: new
Abstract: Jailbreaking attacks on large language models pose a significant threat to AI safety by enabling the generation of harmful or restricted content. While prior work has explored both handcrafted and automated jailbreak strategies, the potential for compositional interaction between simple attacks remains underexplored. This paper presents a systematic study of mutator chaining, in which weak jailbreak transformations are applied sequentially to characterize how they interact: whether they reinforce one another, interfere destructively, or produce no meaningful change. We implement twelve baseline mutators and evaluate all ordered pairs on a benchmark of harmful prompts against three popular LLM models. Our framework introduces metrics for completeness and validity that capture both transformation persistence and attack effectiveness. Results reveal that the interaction landscape is highly non-uniform, while most combinations fail to outperform individual mutators, exhibiting destructive interference or structural incompatibility, a small fraction produce synergistic effects that improve attack success rates. Equally important, the prevalent failure modes reveal structural properties of safety alignment that are not apparent from single-strategy evaluations. These findings highlight the nuanced dynamics of adversarial prompt composition and offer new insights for building more robust safety defenses.
arXiv:2512.00778v2 Announce Type: replace
Abstract: Preference optimization (PO) is indispensable for large language models (LLMs), with methods such as direct preference optimization (DPO) and proximal policy optimization (PPO) achieving great success. A common belief is that DPO is supervised learning while PPO is reinforcement learning, yet deeper analyses for the reasons underlying these differences remain lacking. To fill this gap, we analyze their optimization dynamics, revealing distinct algorithmic behaviors and comprehending their underlying causes. First, we examine the target directions of gradient-based updates and find that DPO follows stable targets, whereas PPO balances exploration and exploitation, validating the common belief yet from this new perspective. Second, we examine the roles of positive learning, negative learning, and loss reweighting, which are three key yet seldom discussed components within PO methods. Our analyses reveal that these components play fairly different roles. In DPO, positive and negative learning jointly shape the targets. However, loss reweighting in DPO acts less as a reward signal but more as a regularizer to mitigate overfitting. In PPO, negative learning primarily supports exploration rather than determining the targets. Meanwhile, loss reweighting, related to the absolute advantages, indicates the distinct roles of token groups in updating targets. Given these findings, we conduct carefully designed ablation studies to further examine how controlling these dynamics impacts optimization efficiency and practical performance. The insights gained from our analyses not only deepen the understanding of PO methods but also inspire the development of more preference-aligned LLMs.
arXiv:2604.26733v4 Announce Type: replace
Abstract: Live future prediction refers to the task of making predictions about real-world events before they unfold. This task is increasingly studied using large language model-based agent systems, and it is important for building agents that can continually learn from the real world. It can provide a large number of prediction questions grounded in diverse real-world events, while preventing answer leakage. To leverage the advantages of future prediction, we present FutureWorld, a live agentic reinforcement learning environment that closes the training loop between prediction, outcome realization, and parameter updates. Specifically, we modify and extend verl-tool, resulting in a new framework that we call verl-tool-future. Unlike standard reinforcement learning training frameworks that rely on immediate rewards, verl-tool-future stores prediction-time rollouts, backfills rewards after real-world outcomes become available, and then replays the completed trajectories for policy update. Across three open-source agents, successive FutureWorld training rounds lead to consistent improvements in prediction accuracy, probabilistic scoring, and calibration, demonstrating that delayed real-world outcome feedback can serve as an effective reinforcement learning signal.
arXiv:2605.15458v1 Announce Type: new
Abstract: Video diffusion models have made rapid progress in perceptual realism and temporal coherence, but they remain primarily optimized for plausible generation rather than verifiable reasoning. This limitation is especially pronounced in tasks where generated videos must satisfy explicit spatial, temporal, or logical constraints. Inspired by the role of reinforcement learning with verifiable rewards (RLVR) in reasoning-oriented language models, we introduce VideoRLVR, a practical recipe for optimizing video diffusion models with rule-based feedback. VideoRLVR formulates video reasoning as the generation of verifiable visual trajectories and consists of an SDE-GRPO optimization backbone, dense decomposed rewards, and an Early-Step Focus strategy for efficient training. The Early-Step Focus strategy restricts policy optimization to the early denoising phase, reducing training latency by about 40% while preserving performance. We evaluate VideoRLVR on Maze, FlowFree, and Sokoban, three procedurally generated domains with objective success criteria. Across these tasks, VideoRLVR consistently improves over supervised fine-tuning baselines, with dense decomposed rewards proving especially important in low-success-rate settings. Our RL-optimized model also outperforms the evaluated proprietary and open-source video generation models on these verifiable reasoning benchmarks and out-of-domain benchmarks. These results suggest that verifiable RL can move video models beyond perceptual imitation toward more reliable rule-consistent visual reasoning.
arXiv:2604.26086v2 Announce Type: replace
Abstract: Accurate quantification of protein-nanoparticle interactions is essential for applications in nanobiotechnology, nanomedicine, and drug delivery. Motivated by recent computational and experimental work, we combine coarse-grained united-atom (UA) models with molecular docking to characterize protein adsorption on SiO_2 nanoparticles. We construct orientation-resolved heatmaps in which polar and azimuthal angles uniquely specify the relative protein-nanoparticle pose, and the map amplitude reports binding propensity via the minimum UA adsorption energy or the docking score. Each angular bin corresponds to a distinct docked complex, enabling systematic comparison of binding geometries across models. To relate docking score landscapes to Boltzmann-averaged UA adsorption energetics, we analyze eight birch pollen allergen proteins previously studied experimentally. Similarity between the two orientational distributions is quantified using the Jensen-Shannon divergence (JSD). We find encouraging agreement between the two approaches in several cases, while also identifying limitations and routes for improvement, including optimized angular resolution and iterative refinement of interaction parameters. Overall, this framework provides a quantitative bridge between coarse-grained energetics and docking outputs at protein-nanoparticle interfaces, supporting improved predictive modeling and mechanistic insight into protein-nanoparticle binding landscapes.
arXiv:2604.21251v5 Announce Type: replace
Abstract: Large language models (LLMs) trained on unfiltered corpora inherently risk retaining sensitive information, necessitating selective knowledge unlearning for regulatory compliance and ethical safety. However, existing parameter-modifying methods face fundamental limitations: high computational costs, uncontrollable forgetting boundaries, and strict dependency on model weight access. These constraints render them impractical for closed-source models, yet current non-invasive alternatives remain unsystematic and reliant on empirical experience. To address these challenges, we propose the Controllable Alignment Prompting for Unlearning (CAP) framework, an end-to-end prompt-driven unlearning paradigm. CAP decouples unlearning into a learnable prompt optimization process via reinforcement learning, where a prompt generator collaborates with the LLM to suppress target knowledge while preserving general capabilities selectively. This approach enables reversible knowledge restoration through prompt revocation. Extensive experiments demonstrate that CAP achieves precise, controllable unlearning without updating model parameters, establishing a dynamic alignment mechanism that overcomes the transferability limitations of prior methods.