arXiv:2605.16037v1 Announce Type: cross
Abstract: Fast and Relaxed Vector Fitting (FRVF) is a frequency-domain system identification approach that has been widely adopted in electrical system modelling, while its application to mechanical systems has remained relatively unexplored. In this work, FRVF is reformulated for the identification of structural modal parameters of an aircraft based on Ground Vibration Test (GVT) data within a Multi-Input Multi-Output (MIMO) framework. The proposed procedure consists of three stages: (i) rational approximation of frequency response functions via an enhanced input-stacking strategy, (ii) identification of system poles from the resulting rational model, and (iii) estimation of modal parameters from the extracted poles and associated residues. The methodology is first numerically validated on a MIMO beam model, with particular emphasis on accuracy and robustness under increasing measurement noise. Subsequently, experimental validation is conducted using GVT data from the BAE Systems Hawk T1A aircraft. The results obtained demonstrate a level of performance comparable to that achieved by existing methods. Overall, the extended MIMO formulation of FRVF exhibits high accuracy and strong robustness to measurement noise, highlighting its suitability for application in GVT-based modal analysis.
Science Journals
arXiv:2605.15636v1 Announce Type: new
Abstract: This note deals with a tearing and interconnecting (special non-overlapping domain decomposition) formulation for magneto-quasi-statics (also known as the eddy current model). Only two subdomains are considered, one conducting and one insulating. Using a straightforward tree-cotree splitting, one can get rid of some kernel components in the non-conducting region, but due to the coupling across the interface, a lot of kernel functions remain that are associated with the interface. The formulation presented here overcomes this problem by using a space splitting into gradient fields and a complementary space. Under a mild condition on that splitting, it is shown that (i) one does not need any gradient part in the non-conducting domain, and therefore no coupling of any gradient components between the two subdomains, (ii) both subdomain operators are invertible, and (iii) although the magnetic vector potential is discontinuous across the subdomain interface, the corresponding magnetic field is globally in H(div).
arXiv:2407.07689v5 Announce Type: replace-cross
Abstract: We give a complete characterization of simple graphs whose adjacency matrices generate binary linear complementary dual (LCD) codes. In particular, we completely characterize a distance-regular graph which yields an LCD code in terms of the intersection array parameters. This necessary and sufficient criterion strengthens the previously known sufficient conditions and unifies the cases of complete, Hamming, Johnson, and Grassmann graphs. As further applications, we prove that non-isomorphic conference graphs with $q \equiv 1 \pmod 8$ yield inequivalent codes and we classify all simple graphs with idempotent adjacency matrices on at most $13$ vertices via mass formulas for binary LCD codes.
arXiv:2605.15635v1 Announce Type: new
Abstract: Linguistic ambiguity is critical to the robustness of Large Language Models (LLMs), yet existing research focuses mostly on English, with limited attention devoted to Chinese. Existing Chinese ambiguity datasets (e.g., CHAmbi) suffer from poor scalability. Guided by Potential Ambiguity (PA) Theory, we design a semi-automatic pipeline to construct CHA-Gen. It is the first PA Theory-grounded Chinese ambiguity dataset, which comprises 5,712 sentences (2,414 ambiguous, 3,298 unambiguous) across 18 potential ambiguous structures. Evaluating LLMs (e.g. Gemma 3, Qwen 2.5/3 series) via direct querying and machine translation, we find that LLMs struggle with ambiguity detection (improved by CoT prompting). Analysis of Qwen3-32B's CoT rationales reveals three common failure modes: ambiguity blindness, misattribution, and premature resolution. Uncertainty quantification with semantic entropy metric shows higher uncertainty for ambiguous sentences. Moreover, instruction tuning induces overconfidence, whereas Base models better capture semantic diversity. We further observe that models exhibit a bias toward dominant interpretations. Our work provides a scalable approach for Chinese ambiguity corpus and insights into LLMs' ambiguity handling, laying a foundation for enhancing Chinese ambiguity research in LLMs.
arXiv:2605.15120v2 Announce Type: replace
Abstract: End-to-end autonomous driving planners are commonly trained by imitating a single logged trajectory, yet evaluated by rule-based planning metrics that measure safety, feasibility, progress, and comfort. This creates a training--evaluation mismatch: trajectories close to the logged path may violate planning rules, while alternatives farther from the demonstration can remain valid and high-scoring. The mismatch is especially limiting for proposal-selection planners, whose performance depends on candidate-set coverage and scorer ranking quality. We propose CLOVER, a Closed-LOop Value Estimation and Ranking framework for end-to-end autonomous driving planning. CLOVER follows a lightweight generator--scorer formulation: a generator produces diverse candidate trajectories, and a scorer predicts planning-metric sub-scores to rank them at inference time. To expand proposal support beyond single-trajectory imitation, CLOVER constructs evaluator-filtered pseudo-expert trajectories and trains the generator with set-level coverage supervision. It then performs conservative closed-loop self-distillation: the scorer is fitted to true evaluator sub-scores on generated proposals, while the generator is refined toward teacher-selected top-$k$ and vector-Pareto targets with stability regularization. We analyze when an imperfect scorer can improve the generator, showing that scorer-mediated refinement is reliable when scorer-selected targets are enriched under the true evaluator and updates remain conservative. On NAVSIM, CLOVER achieves 94.5 PDMS and 90.4 EPDMS, establishing a new state of the art. On the more challenging NavHard split, it obtains 48.3 EPDMS, matching the strongest reported result. On supplementary nuScenes open-loop evaluation, CLOVER achieves the lowest L2 error and collision rate among compared methods. Code data will be released at https://github.com/WilliamXuanYu/CLOVER.
arXiv:2605.16039v1 Announce Type: cross
Abstract: The creation and exploration of new materials under extreme pressure-temperature conditions has become increasingly reliant on laser-heated diamond anvil cell (LHDAC) techniques, which provide direct access to previously unexplored regions of multinary phase diagrams. Whereas numerous high-pressure phases have been identified in situ, systematic recovery and post-synthesis physical property characterization of these materials remain significant challenges. In this work, we present the development of an integrated LHDAC synthesis and demonstrate a practical LHDAC-based synthesis workflow that enables stabilization and recovery of metastable intermetallic phases for subsequent structural and transport studies. Using this approach, we successfully achieved LHDAC synthesis of high-pressure MnSb2 and YbZn2 phases under moderate pressures. Synchrotron X-ray diffraction and spatial mapping confirm dominant formation of the targeted phases, whereas laboratory-based refinement quantifies phase fractions despite intrinsic microstrain and minor secondary phases. High-pressure transport measurements on recovered samples reveal tunable by pressure electronic instabilities in both systems. In MnSb2, pressure suppresses two high-temperature magnetic ordering anomalies, observed in transport, by 5 GPa and for higher pressures induces a new low-temperature feature that increases with further pressure increase. In hexagonal high-pressure YbZn2, an electronic reconstruction emerges at ~11 GPa, characterized by semiconducting-like behavior from ~ 30 K to 300 K and a broad low-temperature coherence crossover near 30 K. Our results establish LHDAC synthesis not only as a structural discovery tool, but also as an experimental platform for investigating correlated quantum states stabilized far from equilibrium thermodynamic conditions.
arXiv:2605.16041v1 Announce Type: cross
Abstract: Machine learning systems increasingly make life-changing decisions about individuals, such as loan approvals, hiring, and cheating detection, raising a pressing question: how can individuals respond to negative decisions made by these opaque systems? While explainable artificial intelligence (XAI) has largely focused on algorithmic recourse -- helping individuals change their features to obtain a desired outcome -- the parallel problem of algorithmic contestability -- helping individuals review and correct erroneous algorithmic decisions -- has received far less attention, despite its central ethical and legal importance. We trace this neglect to the absence of clear formal definitions and a systematic operationalization of contestability as an algorithmic problem. To address it, we propose an operational definition of contestability as a natural complement to recourse: contestability starts from the presumption that a decision may be incorrect and focuses on identifying evidence to challenge and potentially overturn it, whereas recourse assumes the decision is valid and instead provides pathways for changing it. We show that standard XAI explanations, such as counterfactuals, LIME, or Anchors, even when combined with human intuitions about decision continuity or monotonicity, reveal only errors in the neighborhood of the individual, but provide insufficient grounds for overturning the decision at hand. Going thus beyond traditional XAI, we identify three types of evidence warranting reversal according to the decision maker's own ethical standards: predictive multiplicity, incorrect feature values, and neglected overruling evidence. We argue that these render decisions normatively indefensible and thus successfully contestable. Finally, we analyze how existing EU legislation connects to our framework and argue that individuals already hold some legal rights to these forms of evidence.
arXiv:2605.15632v1 Announce Type: new
Abstract: Time-reflection occurs when a wave is propagating in a medium undergoing a large and abrupt change in its properties: the original wave splits into a time-refracted wave and a time-reflected wave, each displaying different features. The time-refracted wave continues along its original course but experiences a frequency shift, whereas the time-reflected wave is propagating backwards in space with a reversed phase, also with a shifted frequency. These phenomena are fundamental to any wave system, but the most interesting are electromagnetic (EM) waves, specifically at optical frequencies, where they can couple to light-matter interactions. However, time-reflection of EM waves was thus far observed only at RF frequencies, never at optical frequencies. This is because time-reflection requires an order-unity variation of the refractive index occurring faster than a single wave cycle, and conventional optical nonlinearities are either too weak or too slow by orders of magnitude. Here, we present the first observation of time-reflection at optical frequencies. We induce an order-unity refractive-index change with sub-cycle duration, observe the time-reflection, and study its fundamental properties. These results provide an experimental pathway to experimenting with time-interfaces, generating photonic time-crystals and exploring new regimes of light-matter interaction in time-varying media.
arXiv:2605.16230v1 Announce Type: cross
Abstract: Magnetic order is a fundamental property of materials, governing collective behavior and enabling a broad range of functionalities. Yet magnetic structure remains difficult to determine: experiments are costly and specialized, while first-principles methods often struggle with the noncollinear and incommensurate orders found in real materials. Here we introduce magnetic structure network (MSN), an E(3) equivariant graph neural network that predicts both collinear and non-collinear magnetic structures directly from atomic crystal structures, trained directly on experimentally determined structures from MAGNDATA. By proposing the primitive modulated structure representation (PMSR), we are able to encode commensurate and incommensurate structures in a unified way without symmetry assumptions. The model achieves strong performance across all modulation components and reconstructs experimental magnetic structures with high fidelity. Our approach provides a scalable framework for rapid magnetic structure prediction and opens a route to data-driven discovery of magnetic materials.
arXiv:2605.14324v2 Announce Type: replace-cross
Abstract: We analyze convergence rates of norm-minimization-based outer approximation algorithms for convex vector optimization when the scalarization uses an $\ell_p$ norm with $p \in (1,\infty)$. While the Euclidean case ($p=2$) achieves the optimal rate $O(k^{2/(1-q)})$, the behavior under general $\ell_p$ norms has remained open. A direct approach via the modulus of smoothness yields only the weaker exponent $\min(p,2)$, which degrades for $1 < p < 2$. We prove that the Hausdorff approximation error satisfies $\delta_H(P_k, A) = O(k^{2/(1-q)})$ for \emph{every} $p \in (1,\infty)$, where $q$ is the number of objectives and $k$ is the iteration count. The proof introduces a Euclidean intermediary technique that exploits the ambient inner product structure of $\R^q$ to obtain a quadratic bound on the hyperplane distance, bypassing the $\ell_p$ smoothness limitation; norm equivalence then converts this to any $\ell_p$ metric at the cost of only a dimension-dependent constant, not a loss of exponent. Numerical experiments confirm the $p$-independent rate predicted by the theory.
arXiv:2605.15093v2 Announce Type: replace
Abstract: The life history of an individual coral is archived within the accreting skeleton of the colony. While reef-forming coral colonies (e.g. massive $\textit{Porites}$ sp.) may live for hundreds of years and deposit calcareous structures many metres in height and width, their living tissue is a thin outer surface layer comprised of asexually-dividing polyps that only survive a few years. To understand the rate and timing of polyp division and the consequences for colony skeletal growth, scientists need to track the skeletal corallite deposited around each polyp. Here we propose CoralLite, an annotated $\mu$CT scan dataset of entire calcareous skeletons and an associated, first corallite deep learning reconstruction baseline. CoralLite combines fully quantified volumetric segmentations with cross-slice linking for visualisations of 3D models for each corallite up to colony scale. For segmentation, we propose and evaluate in detail a hybrid V-Trans-UNet architecture applicable to segmenting tiled $\mu$CT virtual slabs of $\textit{Porites}$ sp. colonies. The model is pre-trained on weakly annotated data and topology-aware fine-tuned using fully annotated slice sections with 8k+ manual corallite region annotations. On unseen slices of the same colony, the resulting model reaches 0.94 topological accuracy at mean Dice scores of 0.77 on the same colony and projection axis, and 0.63 mean Dice scores on a different, biologically unrelated specimen. Whilst our experiments are limited in scale and context, our results show for the first time that visual machine learning can effectively support full 3D individual corallite modelling from $\mu$CT scans of coral skeletons alone. For reproducibility and as a baseline for future research we publish our full dataset of 697 $\mu$CT slices, 37 partial or full slice annotations, and all network weights and source code with this paper.
arXiv:2605.15630v1 Announce Type: new
Abstract: Free energy profiles serve as a fundamental bridge between microscopic atomic fluctuations and macroscopic thermodynamic observables. Estimating the free energy profile along a reaction coordinate, referred to as the potential of mean force (PMF), with density functional theory (DFT) accuracy is computationally expensive. Universal machine learning interatomic potentials (MLIPs) drastically reduce this cost, but their accuracy is strongly determined by their training data and hence can be uncertain for a given system. In this work, we present a systematic and scalable framework for reweighting PMFs, initially sampled with a single 'source' MLIP, across a representative suite of target MLIPs. Because traditional direct exponential reweighting fails for large system sizes due to low phase-space overlap between potentials, we deploy robust analytical corrections. Applying this to a complex 601-atom system of Li$^+$ transport in a nanoconfined electrolyte, we demonstrate that a mean energy-gap approximation effectively bypasses statistical collapse, producing a highly stable PMF matching the target PMF. Using this approach, we recover high-fidelity target thermodynamics across multiple DFT reference levels (PBE+D3, PBE-sol, r$^2$SCAN,r$^2$SCAN-D4) at a fraction of the computational cost of full simulations. Furthermore, thermodynamic analysis reveals that the studied MLIPs partition into two distinct clusters driven by their training data. Our reweighting framework successfully recovers target thermodynamic properties--specifically, reaction and activation free energies--even when the phase-space overlap between potentials is critically low. Ultimately, this approach establishes a vital diagnostic protocol to achieve affordable cross-model consensus on materials chemistry properties without redundant, resource-intensive simulations.
arXiv:2605.15866v1 Announce Type: new
Abstract: The growing adoption of edge computing has created an increasing need for workloads capable of operating under strict resource and energy constraints. Neuromorphic computing, and spiking neural networks (SNNs) in particular, offers an energy-efficient alternative to conventional machine learning through event-driven computation. However, how SNN workloads behave when deployed within modern container orchestration frameworks, especially in edge environments, remains largely unexplored. This paper investigates the feasibility of deploying and orchestrating SNN workloads in a virtual edge environment using Kubernetes, focusing on end-to-end latency, throughput, classification accuracy, infrastructure overhead, and runtime behavior under concurrent load.
Experiments were conducted on a single-node K3d cluster running on a Windows 11 host with WSL2 and Docker Desktop. The results show that SNN workloads are highly sensitive to resource availability. Restricting CPU to 0.5 cores increased median latency by 47.6x and reduced throughput by 49x, while the most constrained configuration failed due to insufficient memory. Classification accuracy remained stable across all working configurations. From an orchestration perspective, K3d successfully deployed and scaled SNN workloads, though its default round-robin routing policy introduced significant tail latency under replica scaling, highlighting a mismatch between stateless load-balancing assumptions and long-running inference workloads.
Overall, this study provides a baseline for deploying neuromorphic workloads in containerized edge environments and highlights the importance of resource provisioning and orchestration configuration. Future work should explore improved routing strategies, memory optimization, and validation on physical edge hardware.
arXiv:2605.15733v1 Announce Type: new
Abstract: Humans abstract experiences into structured representations to facilitate pattern inference and knowledge transfer. While the hippocampal-entorhinal (HPC-MEC) circuit is known to represent both spatial and conceptual spaces, the mechanisms for concurrently extracting abstract structures from continuous, high-dimensional dynamics remain poorly understood. We propose a brain-inspired hierarchical model that simultaneously infers latent transitions and constructs a predictive visual world model. Our architecture employs an inverse model for structural extraction alongside an HPC-MEC coupling model that dissociates relational structures (MEC) from integrated episodic scenes (HPC). Using primitive transformation dynamics as a benchmark, we demonstrate the model's capacity for structural abstraction. By leveraging velocity-driven path integration, the framework enables robust prediction and structural reuse across diverse contexts, thereby achieving structural generalization. This work provides a novel computational framework for understanding how brain-inspired, self-supervised learning of world models facilitates the acquisition of reusable abstract knowledge.
arXiv:2605.15732v1 Announce Type: new
Abstract: In this paper, we present a hypersequent calculus for bimodal logic GR, where the two modalities represent the arithmetic provability predicates of Goedel and Rosser, respectively. We prove the cut-elimination theorem for the calculus.
arXiv:2605.16070v1 Announce Type: cross
Abstract: Antibody-based therapeutics-including antibody-drug conjugates (ADCs), bispecific antibodies, and novel formats-are reshaping oncology, yet key determinants of efficacy, safety, and manufacturability frequently emerge after conjugation and formulation. We argue that computational biophysics provides an underexploited framework to address this gap by connecting molecular interactions to biological outcomes. We highlight how molecular dynamics, coarse-grained simulations, and free energy calculations reveal how conjugation site, linker chemistry, and drug-antibody ratio reshape conformational landscapes. We emphasize structural coupling between antibody, linker, and payload, with implications for antigen binding, internalization, and developability. We propose that integrating physics-based modeling into development pipelines-alongside experimental validation-can reduce empirical iteration and de-risk translation. As force fields, and hybrid physics-machine-learning methods improve, this field is poised to become a central driver of next-generation ADC design.
arXiv:2605.16236v1 Announce Type: cross
Abstract: We theoretically investigate acoustic spin resonance in a spatially homogeneous spinor polariton condensate. A longitudinal acoustic wave generates a time-periodic strain-induced effective magnetic field acting on the condensate pseudospin. When this field is transverse to the static in-plane linear-polarization splitting, it resonantly drives polarization oscillations. We show that spin-dependent interactions shift the resonance and produce nonlinear line shapes, while gain, reservoir dynamics, and spin relaxation make the response dissipative and history-dependent, producing amplitude hysteresis. In the presence of lifetime anisotropy, the condensate can develop a bifurcated stationary state with finite circular polarization, and a resonant acoustic drive can switch between the corresponding out-of-plane branches. A Zeeman splitting provides an additional conservative knob for tuning the resonance frequency. Our results identify coherent acoustic driving as a route to resonant, nonlinear, and switchable control of polariton pseudospin dynamics.
arXiv:2605.15782v1 Announce Type: new
Abstract: In this work, we address the problem of ensuring real-time safety in autonomous robot navigation, in spatially constrained dynamic environments, by utilizing only onboard sensors. We present a real-time control architecture that integrates a 3D LIDAR perception-based composite control barrier function(CBF)-based safety filter directly into the autonomy pipeline. The proposed perception-driven framework enforces collision avoidance constraints dynamically from onboard point cloud data, thus allowing a large number of constraints to be handled at the control frequency, while remaining minimally invasive to nominal task execution. The safety region is defined as an ellipsoid in the body-frame, consistent with the geometry of the platform, which induces time-varying constraints in the world frame as the robot rotates; this effect is handled through a dedicated formulation of time-varying (CBF) for each LIDAR point. We validate the system through multiple field experiments in underground environments by utilizing a quadruped platform performing a visual inspection task, demonstrating reliable operation in the presence of dynamic obstacles, unsafe high-level references, abrupt localization anomalies, and while traversing through narrow corridors.
arXiv:2605.15616v1 Announce Type: new
Abstract: In this work, we consider the One-Fluid Two-Temperature Euler (OFTT-Euler) equations used for modeling non-equilibrium hydrodynamics. The model comprises a system of nonlinear hyperbolic partial differential equations with non-conservative products. The model decomposed the total pressure into two scalar components: one for electrons and one for ions. Our aim in this work is to design entropy-stable finite difference numerical schemes for the model. This is achieved by reformulating the equations such that the reformulated non-conservative part does not contribute to the entropy. Then, we design higher-order entropy-conservative numerical schemes by using Tadmor's relation for the conservative part and higher-order central differences for the non-conservative parts. Finally, we design the entropy-dissipation terms using the entropy-scaled right eigenvectors of the conservative part, thereby deriving the entropy inequality for the entire system. We present several test cases in one and two dimensions to demonstrate the accuracy and stability of the proposed schemes.
arXiv:2605.15779v1 Announce Type: new
Abstract: The integration of Unmanned Aerial Vehicles(UAVs) into Intelligent Transportation Systems (ITS) offers synoptic visibility for traffic monitoring, yet scalable deployment is hindered by trajectory fragmentation, where vehicle identity persistence is lost across multi-UAV Fields of View (FOV). While state-of-the-art frameworks excel in optimizing local trajectory extraction and stability for single-drone imagery, they often function as isolated data silos that generate disjointed trajectories, thereby precluding network-level analysis such as Origin-Destination estimation. This paper presents a real-time Multi-Camera Multi-Vehicle Tracking (MCMT) system designed to handle global identity persistence. Addressing the visual ambiguity and computational cost of appearance-based Re-Identification (Re-ID) in nadir views, we introduce a lightweight Topology-Based Spatiotemporal Handover mechanism. We implement a high-throughput parallel pipeline leveraging YOLO11 and ByteTrack to process concurrent 4K streams. Our core contribution is a deterministic queue-based matching algorithm that utilizes geometric overlaps and virtual lane discretization to predictively manage identity handover via FIFO queues. Experimental results on complex urban environments, including intersections and merging traffic, demonstrate a Handover Success Rate (HOSR) of 99.8% in continuous traffic flows, significantly outperforming Re-ID baselines (74.1%) while validating edge deployment feasibility. The source code is available at https://github.com/JYe9/multi-camera-multi-vehicle-tracking-system.
arXiv:2605.14057v2 Announce Type: replace
Abstract: Most existing dialogue systems are user-driven, primarily designed to fulfill user requests. However, in many critical real-world scenarios, a conversational agent must proactively extract information to achieve its own objectives rather than merely respond. To address this gap, we introduce Inquisitive Conversational Agents (ICAs) and develop an ICA specifically tailored to U.S. Supreme Court oral arguments. We propose a Dual Hierarchical Reinforcement Learning framework featuring two cooperating RL agents, each with its own policy, to coordinate strategic dialogue management and fine-grained utterance generation. By learning when and how to ask probing questions, the agent emulates judicial questioning patterns and systematically uncovers crucial information to fulfill its legal objectives. Evaluations on a U.S. Supreme Court dataset show that our method outperforms various baselines across multiple metrics. It represents an important first step toward broader high-stakes, domain-specific applications.
arXiv:2312.05975v3 Announce Type: replace
Abstract: Explainability is a vital aspect of modern AI for real-world impact and usability. The main objective of this paper is to emphasise the need to understand the predictions of Computer Vision models, specifically Convolutional Neural Network (CNN) models. Existing methods for explaining CNN predictions are largely based on Gradient-weighted Class Activation Maps (Grad-CAM) and focus solely on a single target class; this assumption about the target class selection neglects a large portion of the predictor CNN's prediction process. In this paper, we present an exhaustive methodology, called Fused Multi-class Gradient-weighted Class Activation Map (FM-G-CAM), that considers multiple top-predicted classes and provides a holistic explanation of the predictor CNN's rationale. We also provide a detailed mathematical and algorithmic description of our method. Furthermore, alongside a concise comparison of existing methods, we compare FM-G-CAM with Grad-CAM, quantitatively and qualitatively highlighting its benefits through real-world practical use cases. Finally, we present an open-source Python library with an FM-G-CAM implementation to conveniently generate saliency maps for CNN-based model predictions.
arXiv:2605.15615v1 Announce Type: new
Abstract: Efficient transfer learning of vision-language models (VLMs) commonly suffers from a Base-New Trade-off (BNT): improving performance on unseen (new) classes often degrades accuracy on known (base) classes. Addressing how to boost recognition of unseen classes without sacrificing known-class performance remains a central challenge. Existing work often simplistically attributes the BNT to overfitting on known classes. We observe an interesting phenomenon: VLMs frequently exhibit asymmetric confusion on certain downstream data, i.e., samples of class A are systematically mispredicted as class B, while the reverse confusion (B to A) rarely occurs. For known classes, this kind of bias can be mitigated by tuning using a cross-entropy loss, but for unseen classes, such pretraining-induced bias persists and harms generalization. Motivated by this, we propose NeRP, a plug-and-play prompting correction strategy that improves discrimination on unseen classes without modifying model parameters. NeRP leverages neutral text prompts and reference images to measure class-wise prior preferences along the pre-trained inter-class geometry, and combines them with the sample likelihood to obtain the model's surrogate score. If, for a given sample, the prior strongly favors the current prediction while the observed evidence is clearly insufficient, we perform a local flip between easily confusable class pairs, thereby correcting prior-dominated mispredictions. Extensive experiments across multiple backbones and 15 few-shot and cross-domain benchmarks show that NeRP substantially improves accuracy on unseen classes while preserving known-class prediction performance.
Allostery enables proteins to couple environmental signals to functional outputs, yet how allosteric mechanisms diversify during evolution remains poorly understood. Here, we address this question in the ubiquitous and functionally diverse arsenic repressor (ArsR) superfamily by integrating information-theoretic bioinformatics, structural characterization of DNA recognition and NMR measurements of fast internal dynamics. We identify conserved residues that define the structural scaffold of ArsR proteins and subfamily-specific positions that encode inducer and DNA specificity. In the persulfide sensor SqrR, the crystal structure of the DNA-bound complex reveals how operator specificity is encoded by a limited set of residues, consistent with sequence-derived predictions functionally validated by in vitro transcription assays across divergent ArsR regulators. We further show that allosteric inhibition of DNA binding in SqrR occurs without large-scale conformational rearrangements and is instead associated with changes in internal dynamics, as previously observed for the zinc sensor CzrA. Together, these results support a model in which conformational entropy preserves allosteric connectivity while relaxing sequence constraints, thereby enabling functional diversification within a protein superfamily.
Avoiding fertilization with genetically incompatible partners, whether too similar or too divergent, is a central challenge for sexually reproducing organisms. Selection can favor mechanisms acting before and after mating, with postmating processes potentially compensating for constraints on premating choice. In the postmating context, female reproductive fluid (FRF) can modulate sperm performance and bias fertilization outcomes, but its contribution to reproductive isolation remains unclear. We tested whether FRF mediates discrimination against heterospecific and related sperm in two naturally hybridizing sister species of swordtails, Xiphophorus birchmanni and X. malinche, that diverge in premating behavior towards heterospecifics. Effects of FRF differed sharply between species. In X. malinche, FRF enhanced the velocity of conspecific sperm relative to heterospecifics, consistent with postmating discrimination against hybridization. In contrast, FRF in X. birchmanni did not favor conspecific sperm. Evidence for inbreeding avoidance was weaker, and we found no indication of a trade-off between discrimination against genetically similar and dissimilar sperm. These results show that female reproductive fluid can serve as a rapidly evolving axis of reproductive isolation through postmating female choice.