arXiv:2605.15426v1 Announce Type: cross
Abstract: Entanglement in continuous-variable Gaussian systems is a key resource, and common reservoirs can both suppress and generate correlations. Existing work focused on pre-entangled states or Markovian baths, leaving open whether separable squeezed inputs entangle in structured environments or under modulation. We study two bosonic modes coupled to a common reservoir, each initialized in a separable squeezed vacuum. Dynamics are analyzed utilizing Gaussian covariance methods, evolved under approximate Non-Markovian quantum state diffusion (QSD), finite-temperature pseudomode embeddings, and Bures-based non-Markovian diagnostics. We identify three mechanisms absent in Markovian dynamics: (1) A detuning condition that freezes entanglement trajectories across reservoir correlation times; (2) birth, death, and revival of entanglement from orthogonal inputs; and (3) integer-locked beating with square-wave oscillations produced by periodic detuning. All mechanisms persist at finite temperature, with deviations bounded within 5% in cryogenic regimes and 20% at moderate occupations. These deviation bounds align with cryogenic cavity, phononic, and optomechanical platforms, where structured spectral densities and detuning modulation are already accessible. Structured reservoirs are shown to emerge as tunable entanglement resources for continuous-variable quantum technologies.
Science Journals
arXiv:2507.10236v2 Announce Type: replace
Abstract: As generative Artificial Intelligence (AI) advances, the realism of AI generated imagery has reached a threshold capable of deceiving even vigilant human observers. Yet, while current AI-generated Image Detection (AID) approaches perform exceptionally well on controlled benchmark datasets, they struggle significantly with real-world cases. To study this behavior we introduce the ITW-SM dataset, a curated collection of real and AI-generated images originating from major social media platforms. We employ it to analyze the effects of key design choices typically considered when building a detector, involving its architecture, pre-trained latent spaces, training data as well as pre-processing approaches. We indicate that naively scaling the pre-training stage or opting for more training data does not always lead to better detection performance. Instead, our work reveals that it is crucial to optimize each design choice to enable the processing pipeline to propagate and effectively analyze both low-level traces as well as high-level image semantics. Building on our findings, we achieve a substantial average improvement of 26.87% in AUC across multiple state-of-the-art detection approaches and under real-world conditions, providing a roadmap for developing more resilient detectors. Our assets are available on https://mever-team.github.io/itw-sm.
RanSOM: Second-Order Momentum with Randomized Scaling for Constrained and Unconstrained Optimization
arXiv:2602.06824v2 Announce Type: replace-cross
Abstract: Momentum methods, such as Polyak's Heavy Ball, are the standard for training deep networks but suffer from curvature-induced bias in stochastic settings, limiting convergence to suboptimal $\mathcal{O}(\epsilon^{-4})$ rates. Existing corrections typically require expensive auxiliary sampling or restrictive smoothness assumptions. We propose \textbf{RanSOM}, a unified framework that eliminates this bias by replacing deterministic step sizes with randomized steps drawn from distributions with mean $\eta_t$. This modification allows us to leverage Stein-type identities to compute an exact, unbiased estimate of the momentum bias using a single Hessian-vector product computed jointly with the gradient, avoiding auxiliary queries. We instantiate this framework in two algorithms: \textbf{RanSOM-E} for unconstrained optimization (using exponentially distributed steps) and \textbf{RanSOM-B} for constrained optimization (using beta-distributed steps to strictly preserve feasibility). Theoretical analysis confirms that RanSOM recovers the optimal $\mathcal{O}(\epsilon^{-3})$ convergence rate under standard bounded noise, and achieves optimal rates for heavy-tailed noise settings ($p \in (1, 2]$).
arXiv:2510.10454v2 Announce Type: replace
Abstract: Large language models (LLMs) offer a generalizable approach for modeling patient trajectories, but suffer from the long and noisy nature of electronic health records (EHR) data in temporal reasoning. To address these challenges, we introduce Traj-CoA, a multi-agent system involving chain-of-agents for patient trajectory modeling. Traj-CoA employs a chain of worker agents to process EHR data in manageable chunks sequentially, distilling critical events into a shared long-term memory module, EHRMem, to reduce noise and preserve a comprehensive timeline. A final manager agent synthesizes the worker agents' summary and the extracted timeline in EHRMem to make predictions. In a zero-shot one-year lung cancer risk prediction task based on five-year EHR data, Traj-CoA outperforms baselines of four categories. Analysis reveals that Traj-CoA exhibits clinically aligned temporal reasoning, establishing it as a promisingly robust and generalizable approach for modeling complex patient trajectories. Implementation of Traj-CoA is available on https://github.com/zengsihang/Traj-CoA.
arXiv:2605.16011v1 Announce Type: new
Abstract: Adaptive learning refers to educational technologies that track learners' learning progress and adapt the instructional process based on individual learners' learning performance. It is increasingly recognized as critical for developing an effective learning support tool. Vision language models (VLMs) have seen adoption in mathematics education, and students have been using them as learning aids for personalized instruction. However, it is unknown whether VLMs have the ability to adapt to different learner profiles when providing mathematical instructions. Current VLMs lack a systematic evaluation framework for this adaptivity to different learner profiles in mathematics tutoring tasks. To address this gap, we draw on the learner model from the adaptive learning framework (Shute and Towle, 2018) and propose a learner model-based rubric. Our rubric formalizes adaptivity assessment into three aspects: cognitive aspects, motivational aspects, and complexity. We also evaluate two additional dimensions of VLM responses: correctness (of answers and solutions) and quality (of the response itself). Our experimental results show measurable differences in adaptivity across models and also reveal that current VLMs struggle to consistently produce learner model-based instructional responses, especially when receiving limited learner information.
arXiv:2605.15370v1 Announce Type: cross
Abstract: Accurate salt-body delineation is essential for seismic interpretation because salt structures distort wave propagation, complicate velocity-model building, obscure reservoir geometry, and increase uncertainty in exploration and drilling decisions. Although hybrid quantum-classical models have shown competitive performance on small-scale image-classification tasks, their value for dense, pixel-level geophysical prediction remains largely untested. This work introduces quantum feature gating, a hybrid segmentation architecture that embeds a parameterized quantum circuit (PQC) at feature-fusion points within an encoder-decoder pipeline. A 4-qubit, 2-layer PQC with data re-uploading computes a learned convex combination of lateral and top-down features at each Feature Pyramid Network merge point. A global-average-pooling layer maps encoder features to a fixed 4-dimensional quantum input, decoupling the 72-parameter quantum budget from backbone size and image resolution. The method is evaluated on the 2018 TGS Salt Identification Challenge using 4,000 seismic images at 101 x 101 resolution, across two integration topologies, eight circuit variants, and six encoders with 8M to 118M parameters under five-fold cross-validation. In a controlled EfficientNetV2-L ablation at 256 x 256 resolution, replacing the three Quantum FPN Gates with element-wise addition while holding the encoder, loss schedule, splits, and threshold search fixed reduces mean IoU from 0.9389 to 0.8404, a 9.85 percentage-point gap. Inserting the same circuit as skip-connection attention in a custom U-Net improves IoU by 0.88 points over the SolidUNet baseline, showing that the PQC contribution depends on where and what it gates. These results provide controlled evidence that quantum feature fusion can improve dense seismic segmentation.
arXiv:2412.02271v5 Announce Type: replace
Abstract: We present MediaSpin, a large-scale language resource capturing how major news outlets modify headlines after publication, and MediaSpin-in-the-Wild, a complementary dataset linking these revised headlines to their downstream engagement on social media. The increasing editability of online news headlines offers new opportunities to study linguistic framing and bias through the lens of editorial revisions. The dataset contains 78,910 headline pairs annotated for 13 types of media bias, grounded in established media-bias taxonomies, covering both subjective (e.g., sensationalism, spin) and objective (e.g., omission, slant) forms, with annotation conducted through a human-supervised large-language-model pipeline with expert validation and quality control. We describe the annotation schema and demonstrate three downstream applications: (1) cross-national analysis of how country references are added or removed during editing, (2) transformer-based bias classification at both binary and fine-grained levels, and (3) behavioral analysis of biased headlines on X (Twitter) using 180,786 news-related tweets from 819 consenting users. The results reveal regional asymmetries in representational framing, measurable linguistic markers, and consistently higher engagement with biased content. MediaSpin and MediaSpin-in-the-Wild together provide a reproducible benchmark for bias detection and the study of editorial and behavioral dynamics in contemporary media ecosystems.
arXiv:2504.09544v3 Announce Type: replace
Abstract: Recent advances in self-supervised deep learning have improved our ability to quantify cellular morphological changes in high-throughput microscopy screens, a process known as morphological profiling. However, most current methods only learn from images, despite many screens being inherently multimodal, as they involve both a chemical or genetic perturbation as well as an image-based readout. We hypothesized that incorporating chemical compound structures during self-supervised pre-training could improve learned representations of images from high-throughput microscopy screens. We introduce a representation learning framework, MICON (Molecular-Image Contrastive Learning), that models chemical compounds as treatments that induce transformations of cell phenotypes. MICON significantly outperforms classical hand-crafted features such as CellProfiler and existing deep-learning-based representation learning methods in challenging evaluation settings where models must identify reproducible effects of drugs across independent replicates and data-generating centers. We demonstrate that incorporating chemical compound information into the learning process provides small, but consistent improvements in performance and that modeling compounds specifically as treatments outperforms approaches that directly align images and compounds in a single representation space. Our findings point to a new direction for representation learning in morphological profiling, suggesting that methods should explicitly account for the multimodal nature of microscopy screening data.
arXiv:2411.10037v3 Announce Type: replace
Abstract: Effective usage of approximate circuits for various performance trade-offs requires accurate computation of error. MCAC is a novel model counting framework for exact computation of several average and worst-case error metrics that are used to evaluate approximate circuits. Unlike other methods in the literature, our framework uses the same error miter for all metrics. It requires a single synthesis of the system consisting of the exact and approximate circuits followed by a subtractor that finds the difference of the two outputs. Existing miter-based methods require multiple calls to the model counter, one for each output of the miter. MCAC uses the CNF formula of the system to compute all metrics. Our algorithm converts the formula to a tree and uses message passing to compute all metrics. We propose data structures to efficiently store and perform sparse computations required for conversion to a tree and message passing. Results for all the error metrics for several benchmark instances show a significant speedup over using off-the-shelf model counters along with specialized miters for each metric.
arXiv:2410.01990v3 Announce Type: replace
Abstract: This paper explores alternative formulations of the Kolmogorov Superposition Theorem (KST) as a foundation for neural network design. The original KST formulation, while mathematically elegant, presents practical challenges due to its limited insight into the structure of inner and outer functions and the large number of unknown variables it introduces. Kolmogorov-Arnold Networks (KANs) leverage KST for function approximation, but they have faced scrutiny due to mixed results compared to traditional multilayer perceptrons (MLPs) and practical limitations imposed by the original KST formulation. To address these issues, we introduce ActNet, a scalable deep learning model that builds on the KST and overcomes many of the drawbacks of Kolmogorov's original formulation. We evaluate ActNet in the context of Physics-Informed Neural Networks (PINNs), a framework well-suited for leveraging KST's strengths in low-dimensional function approximation, particularly for simulating partial differential equations (PDEs). In this challenging setting, where models must learn latent functions without direct measurements, ActNet consistently outperforms KANs across multiple benchmarks and is competitive against the current best MLP-based approaches. These results present ActNet as a promising new direction for KST-based deep learning applications, particularly in scientific computing and PDE simulation tasks.
arXiv:2604.20127v2 Announce Type: replace
Abstract: Failures in complex systems often emerge through gradual degradation and the propagation of stress across interacting components rather than through isolated shocks. Democratic systems exhibit similar dynamics, where weakening institutions can trigger cascading deterioration in related institutional structures. Traditional reliability and survival models typically estimate failure risk based on the current system state but do not explicitly capture how degradation propagates through institutional networks over time. This paper introduces a trajectory-aware reliability modeling framework based on Dynamic Causal Neural Autoregression (DCNAR). The framework first estimates a causal interaction structure among institutional indicators and then models their joint temporal evolution to generate forward trajectories of system states. Failure risk is defined as the probability that predicted trajectories cross predefined degradation thresholds within a fixed horizon. Using longitudinal institutional indicators, we compare DCNAR-based trajectory risk models with discrete-time hazard and Cox proportional hazards models. Results show that trajectory-aware modeling consistently outperforms Cox models and improves risk prediction for several propagation-driven institutional failures. These findings highlight the importance of modeling dynamic system interactions for reliability analysis and early detection of systemic degradation.
arXiv:2605.15883v1 Announce Type: cross
Abstract: Precise control of magnetic domain formation at the nanoscale remains constrained by stochastic defect-mediated and unstable pinning, limiting scalability and reproducibility in spintronic architectures. Here we demonstrate that spatially engineered anisotropy gradients provide a deterministic alternative. Using focused Ga+-ion irradiation, we pattern magnetic energy landscapes containing nanoscale "anisotropy wells" that confine magnetic domain walls and enable bidirectional sequential switching without reliance on difficult-to-control material disorder. An analytical framework describing domain-wall energetics in graded anisotropy profiles yields predictive design rules for depinning and stability, which are supported by micromagnetic simulations and experiments. We realize programmable multi-domain configurations in continuous ferromagnetic films and demonstrate robust, reproducible switching of 750 nm regions, while first results for 100 nm are shown, approaching the theoretical limit set by the domain-wall width. By replacing unstable pinning with engineered energy landscapes, this anisotropy landscape establishes a scalable materials strategy for deterministic magnetic-state programming and opens a pathway toward dense, energy-efficient spintronic and reconfigurable magnetic nanodevices.
arXiv:2605.15366v1 Announce Type: cross
Abstract: We present hybrid quantum-classical pipelines for solving the Duffing equation that leverage Carleman linearization and the Variational Quantum Linear Solver (VQLS). First, we demonstrate that Carleman linearization accurately approximates the weakly nonlinear Duffing equation, with errors diminishing as the truncation order increases. Next, across IBM and Xanadu platforms, we deploy VQLS with symmetry-grouped Hadamard Test evaluations under both global and local cost formulations, compare distinct Hermitianization within a common cost framework, and benchmark hardware-efficient ansatz architectures under a fixed Hermitianization. Across block-banded test cases, each method achieves near-unity fidelity and vanishing relative residuals. These results show that topology-agnostic ansatz, optimized Hermitianization, and efficient cost formulation enable VQLS to recover quantum states proportional to classical solutions for Carleman-structured systems, providing a portable recipe for quantum-in-the-loop simulation of nonlinear dynamics.
arXiv:2302.09758v5 Announce Type: replace
Abstract: A recently proposed superconducting linear collider with energy recovery (ERLC) and multiple beam reuse employs twin RF structures to eliminate parasitic collisions in the linacs. Such a collider can operate in either pulsed or continuous-wave (CW) mode, achieving a luminosity of ${\cal O}(10^{36})$ cm$^{-2}$s$^{-1}$ at $2E_0$ = 250--500 GeV. This paper demonstrates that in pulsed mode, the ERLC luminosity is independent of the accelerating gradient for a fixed total power, enabling operation at the highest available gradients. A similar independence holds for the CW mode when the available power significantly exceeds the operational threshold. The luminosity scales with the cavity quality factor as $L\propto Q_0^{1/2}$. We also present, for the first time, a study of a twin $e^-e^-$ ERLC and estimate its performance. This configuration is simpler than the $e^+e^-$ version as it eliminates the need for beam recirculation; electrons can be generated anew for each cycle. In this case, the luminosity scales as $L\propto Q_0^{1/4}$. Furthermore, the use of traveling-wave (TW) RF structures allows for higher gradients and reduced thermal loading. We show that an ERLC with $G$ = 40 MeV/m can operate in CW mode, reaching luminosities of $L_{e^+e^-}$= (1-2.5)$\times 10^{36}$ and $L_{e^-e^-}$= (3-7)$\times 10^{36}$ cm$^{-2}$s$^{-1}$ at $2E_0$ = 250 and 500 GeV, respectively, with a total power consumption of 150-300 MW. These results position the ERLC as a highly promising candidate for a future Higgs factory.
arXiv:2510.03161v2 Announce Type: replace
Abstract: With the rapid advancements in image generation, synthetic images have become increasingly realistic, posing significant societal risks, such as misinformation and fraud. Forgery Image Detection and Localization (FIDL) thus emerges as essential for maintaining information integrity and societal security. Despite impressive performances by existing domain-specific detection methods, their practical applicability remains limited, primarily due to their narrow specialization, poor cross-domain generalization, and the absence of an integrated adaptive framework. To address these issues, we propose UniShield, the novel multi-agent-based unified system capable of detecting and localizing image forgeries across diverse domains, including image manipulation, document manipulation, DeepFake, and AI-generated images. UniShield innovatively integrates a perception agent with a detection agent. The perception agent intelligently analyzes image features to dynamically select suitable detection models, while the detection agent consolidates various expert detectors into a unified framework and generates interpretable reports. Extensive experiments show that UniShield achieves state-of-the-art results, surpassing both existing unified approaches and domain-specific detectors, highlighting its superior practicality, adaptiveness, and scalability.
arXiv:2605.16189v1 Announce Type: cross
Abstract: We present a quantum algorithm for solving algebraic Riccati equations, with applications to quantum-chemical random-phase approximation (RPA) and higher-order RPA theories. Our method block-encodes stabilizing Riccati solutions via Riesz projectors onto invariant subspaces of an associated non-normal matrix, implemented using contour-integral resolvents and quantum singular value transformations. Applied to $m$-particle, $m$-hole RPA, our algorithm yields a block-encoding of the amplitude solution and estimates the electronic correlation-energy density with it. Under localized-orbital sparsity assumptions, the end-to-end cost scales linearly with system size and polynomially with excitation rank $m$, suggesting an exponential advantage in $m$ over plausible classical local-correlation heuristics. More broadly, this work provides a framework for quantum algorithms for nonlinear matrix equations in quantum chemistry and opens a possible route toward developing quantum algorithms for coupled-cluster theory.
arXiv:2605.15707v1 Announce Type: cross
Abstract: Whole-heart multi-compartment CT segmentation is clinically important, but standard CNNs do not explicitly enforce anatomical plausibility. Based on statistics derived from the training data, we evaluate whether lightweight explicit shape priors, implemented as shape-aware losses and spatial label distribution heatmap-guided U-Net variants, improve 3D cardiac segmentation on MM-WHS CT and WHS++. Across all experiments, a standard 3D U-Net surprisingly remained a very strong baseline, with handcrafted priors yielding at best marginal and inconsistent changes and often degrading performance. These results suggest that the baseline already captures substantial implicit anatomical regularities and that future gains will likely require more expressive learned priors rather than simple handcrafted anatomical shape constraints.
arXiv:2212.13347v3 Announce Type: replace
Abstract: We report a diffuse Maxwellian illumination scheme for wide-field retinal laser Doppler holography. Inserting an engineered diffuser in the illumination arm transforms a spatially concentrated near-infrared laser focus into an angularly diversified illumination pattern, thereby reducing local irradiance near the anterior segment while preserving coherent interferometric detection. This configuration allows the eyepiece to be positioned closer to the cornea, increasing the digitally reconstructed retinal field of view without producing a localized corneal hot spot. We compare three illumination geometries: focused non-diffuse illumination, diffuse illumination at the same cornea--eyepiece distance, and diffuse Maxwellian illumination. Diffuse Maxwellian illumination expands the retinal field of view while preserving Doppler contrast in broad and high-frequency fluctuation bands. Light-hazard assessment is limited to the current ophthalmic standards ISO 15004-2:2024 and ANSI Z80.36-2021. Based on measured beam profiles, the recommended operating power at 852 nm is set by the most restrictive relevant exposure condition among the assessed anterior-segment, iris, and retinal limits. These results support diffuse illumination as a practical route toward safer, non-mydriatic, wide-field Doppler holography of the human retina.
arXiv:2605.15266v1 Announce Type: cross
Abstract: Preparing arbitrary logical states is a central primitive for universal fault-tolerant quantum computation and the cost of encoded-state preparation contributes directly to the overall resource overhead. This makes the synthesis of efficient general-state encoding circuits an important problem, particularly with respect to two-qubit gate count and circuit depth. Yet the synthesis of such encoders has been studied less extensively than general Clifford circuit synthesis or the preparation of specific logical Pauli-eigenstates. In this work, we develop methods for synthesizing efficient encoders for arbitrary stabilizer codes. We formulate encoder synthesis as a search over stabilizer tableaus and introduce greedy and rollout-based algorithms that exploit the freedom among stabilizer-equivalent realizations of the same encoding isometry. For code families with a modular structure, such as generalized concatenated and holographic codes, we show how large encoders can be assembled from optimized local constituent encoders, and we use SMT-based exact synthesis to obtain optimal local circuits for small instances. We further evaluate the proposed methods on a broad set of stabilizer codes, including holographic and quantum low-density parity-check (qLDPC) codes, and compare them against recent encoder-synthesis methods and existing constructions from the literature, obtaining improvements of up to 43% in two-qubit gate count and up to 70% in depth. Our results support the optimization of encoded-state preparation in several fault-tolerant quantum-computing schemes, and all methods are openly available as part of the Munich Quantum Toolkit.
arXiv:2311.14344v3 Announce Type: replace-cross
Abstract: This work presents a tensor-network formulation of the Traveling Salesman Problem (TSP) and several of its variants. The approach represents candidate tours with tensor-network layers, weights them by Boltzmann factors, and enforces constraints through explicit counting filters. This formalism also yields an explicit tensor-network marginal formula whose zero-temperature, exact-arithmetic limit identifies an optimal feasible tour through a sequential marginal rule. At finite $\tau$ and finite precision, the implemented extraction is a heuristic whose behavior depends on numerical contrast, calibration, and near-degeneracies. We adapt the construction to several generalizations of the TSP and apply it to the Job Reassignment Problem, as a representative industrial integration. The experiments are deliberately small and illustrative; they contextualize the method against exact and heuristic references but do not establish general computational superiority over specialized classical solvers.
arXiv:2601.03707v2 Announce Type: replace
Abstract: Existing UAV vision-and-language navigation (VLN) benchmarks rarely provide realistic aerial scenes, natural process-level instructions, and sufficient scale simultaneously, making it difficult to systematically train and evaluate UAV VLN agents under realistic settings. To address this, we propose \textbf{AirNav}, a large-scale benchmark built on real urban aerial data, comprising 137K navigation samples with natural and diverse instructions generated via a human--LLM collaborative pipeline with 10 user personas. We conduct a systematic evaluation of representative approaches on AirNav, ranging from traditional models to multimodal large language models (MLLMs), under unified metrics with open-source implementations. We further propose \textbf{AirVLN-R1}, trained via supervised fine-tuning (SFT) and reinforcement fine-tuning (RFT), achieving state-of-the-art performance with a 51.82\% success rate on the test-unseen split. Real-world experiments on a physical UAV platform provide preliminary evidence of sim-to-real transferability, and our dataset and code are publicly available.
Susceptibility to viral infection varies widely but is not fully explained by genetics, immune status, or exposure level. We show that time of day strongly influences infection outcome, with up to 100-fold differences in enteric viral burden depending on infection timing. This temporal gating is abolished in mice lacking a functional circadian clock. We identify the antiviral transcription factor IRF1 as a direct target of the circadian transcription factor BMAL1, resulting in rhythmic expression of a basal antiviral gene program prior to infection. Loss of IRF1 eliminates this program and abrogates time-of-day dependent differences in viral replication. This circuit operates within intestinal myeloid cells, establishing a preexisting antiviral state. These findings indicate that the circadian clock programs host susceptibility in the intestine, before infection occurs.
Allostery enables proteins to couple environmental signals to functional outputs, yet how allosteric mechanisms diversify during evolution remains poorly understood. Here, we address this question in the ubiquitous and functionally diverse arsenic repressor (ArsR) superfamily by integrating information-theoretic bioinformatics, structural characterization of DNA recognition and NMR measurements of fast internal dynamics. We identify conserved residues that define the structural scaffold of ArsR proteins and subfamily-specific positions that encode inducer and DNA specificity. In the persulfide sensor SqrR, the crystal structure of the DNA-bound complex reveals how operator specificity is encoded by a limited set of residues, consistent with sequence-derived predictions functionally validated by in vitro transcription assays across divergent ArsR regulators. We further show that allosteric inhibition of DNA binding in SqrR occurs without large-scale conformational rearrangements and is instead associated with changes in internal dynamics, as previously observed for the zinc sensor CzrA. Together, these results support a model in which conformational entropy preserves allosteric connectivity while relaxing sequence constraints, thereby enabling functional diversification within a protein superfamily.
Linkage disequilibrium (LD) makes causal GWAS variants indistinguishable from correlated neighbours; resolving them is the fine-mapping problem, and the challenge is species-specific: humans face dense ancestry-imbalanced LD, yeast and *Arabidopsis* exceptionally long LD, and crop germplasm sparse and fragmented annotations that defeat human-biobank curation pipelines. Bayesian fine-mappers integrate annotations as flat per-variant priors, discarding the relational structure linking variants to tissue-specific eQTLs, pathways and protein-protein interactions. Hierarchical belief propagation (HBP) on a variant-gene-pathway factor graph matches Bayesian baselines at 5-40x speed; an annotation-adaptive complement, graph-augmented fine-mapping (GAFM), wins 27-2 against SuSiE at weak signal and recovers *LDLR*, *APOE*, *LPL*, *GCKR* and *ANGPTL3* at single-variant resolution across four Pan-UK Biobank ancestries. On the 3,000 Rice Genomes grain weight + shape panel, mixture-prior posterior reweightings of GAFM/HBP and their ensemble (GAFM-MX, HBP-MX, ENS) reach 47.6% top-1-PIP exact-position recovery of 21 panel-matched stable QTNs - the highest of any method, exceeding SuSiE (28.6%) and SBayesRC (14.3%) - at 200-700x SuSiE's per-locus speed. Across 692 leads in four species, a non-uniform per-variant prior, not uniform high coverage, lets the graph break LD ties: adding a regulatory-element flag to an otherwise uniform human cache flips HBP narrower than GAFM from 0% to 88% on 321 Pan-UKB leads. These results recast multi-omics fine-mapping as a non-uniform-prior-curation problem rather than a uniform-coverage problem, and reframe post-GWAS analysis as message passing over biological structure rather than weighted regression on flattened annotations.
Rapid connectivity alterations of thalamic nuclei during initial learning of goal-directed behaviour
The thalamus is essential for learning, dynamically engaging with other subcortical and cerebral cortex regions throughout the learning process. Here, the thalamus serves as a critical connector hub and synchroniser within the thalamocortical system of the brain. However, whilst higher order thalamic nuclei are known to be particularly important for this process, the exact contributions of individual higher order and first order thalamic nuclei, alongside their individual involvement with cortical networks and subcortical regions, remains unexplored within the initial phase of learning. In light of this, we analysed fMRI data obtained within a paradigm which is designed to examine initial learning processes within feedback-driven stimulus-response learning, in order to explore thalamic contributions. We investigated dynamic learning-related functional connectivity alterations between various thalamic nuclei with other subcortical regions and cortical networks. Our results show that the initial phase of learning was associated with: (1) decreasing functional connectivity between thalamic nuclei and frontoparietal and cingulo-opercular networks, (2) increasing functional connectivity between thalamic nuclei with default mode and salience networks, (3) decreasing functional connectivity between thalamic nuclei and the putamen, and (4) decreasing functional connectivity amongst higher order thalamic nuclei. Furthermore (5) these dynamic alterations were associated primarily by mediodorsal thalamus. Altogether, these results indicate that higher order thalamic nuclei play a crucial role within initial learning and in the generation of novel goal-directed behaviour. This was demonstrated through enhanced functional connectivity with selected cortical networks which drive goal-directed behaviour, alongside decreased functional connectivity with striatal regions which drive motor selectivity.