Science Journals

This JAMA Patient Page describes how Ebola is transmitted, how common the infection is and where outbreaks have occurred, risk factors and symptoms, and how it is diagnosed and treated.

Blood-based multicancer detection (MCD) technologies have been touted as a revolution in early-stage population screening and testing for a wide range of cancers. MCDs (often called liquid biopsies) look for fragments of DNA and other biomarkers in the blood, which may indicate the presence of cancer and predict where it originated. The seductive premise has been clear: detecting cancer earlier and intervening at an earlier stage will cure more patients. Given this promise, the commercial market has grown to more than 24 companies, and the annual global market for these MCD technologies is estimated to reach US $2.9 billion by 2030.

The conduct of randomized clinical trials (RCTs) is often a large-scale endeavor, with the potential to impact patients, clinicians, health care systems, and even the communities in which they are carried out. The effects of trials on participants may flow through the randomized study treatments or through other pathways, for example, by inducing changes to aspects of care separate from the randomized treatments. These effects may be beneficial (eg, participants may receive more careful evaluation, additional diagnostic studies, closer follow-up, or earlier detection of complications) or they may be harmful (eg, inconvenience or financial costs).

This Viewpoint discusses some specific challenges in defining estimands for cluster randomized trials and illustrates how the CRT-Estimands Framework can be applied to improve the interpretation of trial results.

The study aimed to determine whether treatment with teriparatide, a parathyroid hormone analogue, followed by zoledronic acid, lowers the risk of fractures in adults with osteogenesis imperfecta compared with standard therapy.

The US Food and Drug Administration (FDA) released a warning advising consumers against using over-the-counter skin lightening products, which may contain high levels of mercury or hydroquinone.

This Perspective discusses female biology and resilience regarding Alzheimer disease despite pathologic risk.

This randomized clinical trial compares whether the addition of zoledronic acid to teriparatide compared with standard treatment reduces fractures among adults with osteogenesis imperfecta.

This JAMA Insights discusses the clinical presentation, diagnosis, and treatment of exocrine pancreatic insufficiency.

To the Editor The Special Communication from the European Society of Gynaecological Oncology (ESGO) about opportunistic salpingectomy for ovarian cancer prevention provided a timely and comprehensive synthesis of the biological rationale, safety profile, and growing consensus supporting this intervention.

In Reply Dr Meyer and colleagues and Drs Afors and Saridogan provide thoughtful comments on our Special Communication about opportunistic salpingectomy for prevention of tubo-ovarian carcinoma.

JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, spoke with Nigam Shah, MBBS, PhD, a professor of medicine at Stanford University and chief data scientist at Stanford Health Care, about the integration of AI into electronic health records for JAMA+ AI Conversations.

This cohort study examines the association of sedentary behavior with adverse pregnancy outcomes, including hypertensive disorders of pregnancy, and the effects of light-intensity physical activity and daily steps on these outcomes.

This cross-sectional study uses data from cancer alliance regions in England to assess whether regional participation in a population-based screening trial of a cell-free DNA-based multicancer early detection test was associated with changes in cancer diagnostic delay rates.

To the Editor Dr Short and colleagues provided a timely and clinically meaningful update on perinatal HIV management, including the expanded role of shared decision-making for breastfeeding among individuals with sustained viral suppression receiving antiretroviral therapy (ART). As these recommendations are increasingly incorporated into US clinical practice, an additional consideration is the dynamic nature of virologic control in the postpartum period.

In the Review titled “Prepregnancy Care and Counseling: A Review,” published in the May 19, 2026, issue of JAMA, a reference was incorrectly cited and another reference was inadvertently omitted from the article. In the fifth paragraph of the Cardiovascular Disease section of text, the sentence “Testing may include electrocardiography, echocardiography, exercise testing, electrophysiology studies, and genetic evaluation for conditions such as Marfan syndrome, long QT syndrome, and hypertrophic cardiomyopathy” was revised to cite reference 74. Additionally, in the Cannabis subsection of the Substance Use section of text, the sentence “A systematic review and meta-analysis (51 studies; 21 146 938 patients) reported that cannabis use during pregnancy was associated with increased odds of low birth weight (OR, 1.75; 95% CI, 1.41-2.18; 20 studies), preterm birth (OR, 1.52; 95% CI, 1.26-1.83; 20 studies), small for gestational age (OR, 1.57; 95% CI, 1.36-1.81; 12 studies), and perinatal mortality (OR, 1.29; 95% CI, 1.07-1.55; 6 studies)” should have cited the following study: Lo JO, Ayers CK, Yeddala S, et al. Prenatal cannabis use and neonatal outcomes: a systematic review and meta-analysis. JAMA Pediatr. 2025;179(7):738-746. doi:10.1001/jamapediatrics.2025.0689. Because of this additional study, the seventh sentence in the Methods section was revised to “This Review includes 119 articles, consisting of…16 systematic reviews and meta-analyses…” and references 114-118 were renumbered to 115-119. This article was corrected online.

This cross-sectional study assesses National Institutes of Health (NIH) data from fiscal years 2016-2025 comprising annual counts of principal investigators funded through research grants and fellowship grant recipients, stratified by self-reported sex, race, ethnicity, and disability status.

Diabetes incidence is rising in the US, with more than 40 million US residents living with this condition. Diabetes morbidity and mortality are unequally distributed, and new diagnoses are higher among American Indian/Alaska Native, Black, and Hispanic adults, compared with White adults. Managing prescription medications is critical to reducing diabetes morbidity, as is controlling risk factors and associated comorbid conditions. However, the cost of pharmacologic therapy has increased substantially, driven in part by the growing use of newer glucose-lowering agents. The high cost of these medications comprises a substantial portion of diabetes-related health care expenditure for individuals with diabetes and may result in restrictive coverage by health plans insuring enrollees with diabetes, further limiting access to care. The out-of-pocket costs faced by patients are particularly burdensome, because patients also face the consequences of adverse downstream outcomes that result from reduced medication adherence due to costs.

This Review discusses the pathophysiology of cardiovascular complications in adults with cyanotic congenital heart disease after early management and examines late complications and management strategies.

This Viewpoint discusses slow life support, a care strategy used when clinicians believe patient recovery is impossible but cannot negotiate full withdrawal of therapies, and provides ethical analysis and practical recommendations for such practices.

The Review titled “Chronic, Noninfectious Diarrhea: A Review,” published on March 2, 2026, was corrected to remove a sentence in the Secretory Diarrhea section that misstated the results of a cited reference. This article was corrected online.

Amateur soccer heading may be associated with acute increases in blood biomarkers of neural damage, findings published in JAMA Neurology suggest.

This Viewpoint discusses the US Centers for Medicare & Medicaid Services’ Increasing Organ Transplant Access Model and outlines pathways to monitor the implementation of the model to ensure equitable access for all patients.

This cost-effectiveness analysis assesses the lifetime health benefits and costs of invitation to 1-time Helicobacter pylori stool antigen testing added to biennial fecal immunochemical test (FIT) screening compared with FIT alone.