arXiv:2606.05650v1 Announce Type: new
Abstract: Dynamic 3D Gaussian Splatting (3DGS) holds great promise as a 3D video streaming technology since it can represent complex 3D scenes with high fidelity. In this approach, every frame in a 3D video represents the environment as a collection of Gaussians with position and other attributes such as scale, rotation, opacity, and color. Frames capture fine details, permit views from any arbitrary perspective, but are an order of magnitude, or more, larger than 2D video frames. A line of recent work has explored how to compress dynamic 3DGS frames, but these approaches are often slow, in part because their compression techniques are not amenable to efficient acceleration. GS-NFS accelerates dynamic 3DGS compression and decompression on a GPU, to the point where it can encode and decode at full frame rate. It achieves this by developing novel GPU-based parallelizations of existing algorithms for encoding both positions and attributes of Gaussians. As a result, it is 1-2 orders of magnitude faster than the state-of-the-art in encoding and decoding a frame, while offering competitive compression performance and rendering quality.
Science Journals
arXiv:2604.21017v3 Announce Type: replace
Abstract: Autonomous medical robots hold promise to improve patient outcomes, reduce provider workload, democratize access to care, and enable superhuman precision. However, autonomous medical robotics has been limited by a fundamental data problem: existing medical robotic datasets are small, single-embodiment, and rarely shared openly, restricting the development of foundation models that the field needs to advance. We introduce Open-H-Embodiment, the largest open dataset of medical robotic video with synchronized kinematics to date, spanning more than 50 institutions and multiple robotic platforms including the CMR Versius, Intuitive Surgical's da Vinci, da Vinci Research Kit (dVRK), Rob Surgical BiTrack, Virtual Incision's MIRA, Moon Surgical Maestro, and a variety of custom systems, spanning surgical manipulation, robotic ultrasound, and endoscopy procedures. We demonstrate the research enabled by this dataset through two foundation models. GR00T-H is the first open foundation vision-language-action model for medical robotics, which is the only evaluated model to achieve full end-to-end task completion on a structured suturing benchmark (25% of trials vs. 0% for all others) and achieves 64% average success across a 29-step ex vivo suturing sequence. We also train Cosmos-H-Surgical-Simulator, the first action-conditioned world model to enable multi-embodiment surgical simulation from a single checkpoint, spanning nine robotic platforms and supporting in silico policy evaluation and synthetic data generation for the medical domain. These results suggest that open, large-scale medical robot data collection can serve as critical infrastructure for the research community, enabling advances in robot learning, world modeling, and beyond.
arXiv:2110.06847v3 Announce Type: replace
Abstract: From work emerging through the middle of the 20th century, the essence of meaning has become widely accepted as being described by the three orthogonal dimensions of valence, arousal, and dominance (VAD). These essential dimensions have become the cornerstone of sentiment analysis across many fields. By re-examining first types and then tokens for the English language, and through the use of automatically annotated histograms -- `ousiograms' -- we find here that: The essence of meaning conveyed by words is instead best described by a goodness-power-aggression-danger-structure circumplex framework (GPADS); that large-scale English language corpora reveal a systematic bias toward safe, low-danger words; and that the power-danger-structure (PDS) framework is the minimal framework that represents essential meaning. We find remarkable congruences between the GPADS framework and other spaces including mental states and fictional archetypes, and we construct and demonstrate a prototype ousiometer.
arXiv:2308.10897v2 Announce Type: replace
Abstract: We present a framework for generating appropriate facial responses from a listener in dyadic social interactions based on the speaker's words. Given an input transcription of the speaker's words with their timestamps, our approach autoregressively predicts a response of a listener: a sequence of listener facial gestures, quantized using a VQ-VAE. Since gesture is a language component, we propose treating the quantized atomic motion elements as additional language token inputs to a transformer-based large language model. Initializing our transformer with the weights of a language model pre-trained only on text results in significantly higher quality listener responses than training a transformer from scratch. We show that our generated listener motion is fluent and reflective of language semantics through quantitative metrics and a qualitative user study. In our evaluation, we analyze the model's ability to utilize temporal and semantic aspects of spoken text. Project page: https://people.eecs.berkeley.edu/~evonne_ng/projects/text2listen/
arXiv:2308.13527v2 Announce Type: replace
Abstract: The Special Relativity allows the possibility of a class of particles, known tachyons, that have spacelike 4-velocities, i.e., which move with velocity greater than speed of light in vacuum. In this existence frame, the tachyons have energy and momentum and they must contribute to the gravitational field through by the means of the energy-momentum tensor. The superluminal perfect fluid tensor is obtained assuming the framework Lagrangian formalism and spacelike 4-velocities flowlines of tachyons with energy density. The perfect fluid of tachyons gives rise a positive energy density and a form of negative pressure, which according to various cosmological theoretical results, it is associated with dark energy.
arXiv:2402.02247v4 Announce Type: replace
Abstract: Numerical approximations of Landau-type operators represent fundamental components of time integration methods for demanding problems such as inhomogeneous Vlasov-Landau-type equations. Substantial computational issues arise from the treatment of the physically most relevant three-dimensional case with Coulomb-type interaction. This work is concerned with the introduction and numerical comparison of novel approaches for the reliable and efficient evaluation of Landau-type collision operators, where the focus is on the treatment of integral operators involving general singular kernels. In the spirit of collocation, common tools are the identification of fundamental integrals, series expansions of the integral kernel and the density function on the main part of the velocity domain, and interpolation as well as quadrature approximation nearby the singularity of the kernel. Focusing on the favourable choice of the Fourier spectral method, their practical implementation uses the reduction to basic integrals, fast Fourier techniques, and summations along certain directions. Moreover, an important observation is that a significant percentage of the overall computational effort can be transferred to precomputations which are independent of the density function. For the purpose of exposition and numerical validation, the cases of constant, regular, and singular integral kernels are distinguished, and the procedure is adapted accordingly to the increasing complexity of the problem.
arXiv:2605.26761v2 Announce Type: replace
Abstract: Multimodal instruction tuning is the de facto recipe for adapting vision language models (VLMs), yet instruction data are highly redundant, making data selection critical for training efficiency. Existing methods derive selection signals from a specific model or dataset, so whenever the target model or candidate pool changes, the criteria must be recomputed from scratch at substantial cost. To address this, we propose OFA, a data selection framework that trains a reusable selector once and applies it to any dataset or model without recomputation. OFA clusters multimodal instructions in a frozen CLIP space, derives pseudo labels from the cluster structure, and trains a lightweight selector for only a few epochs; samples on which this selector is least confident are selected as the most informative. Once trained, the frozen selector transfers directly across datasets and model scales. The selector is trained once on LLaVA-665K and applied both to LLaVA-665K itself and, without any retraining, to the unseen Vision-Flan-186K. Selecting only 15% of the data, OFA achieves 98.3% of full data performance across 10 downstream benchmarks; on the smaller Vision-Flan-186K, the transferred selector surpasses full data training by 10.6%, confirming that the learned signal generalizes to datasets never seen during selector training. The same selected subsets benefit VLMs at both Qwen2.5-VL-3B and LLaVA-v1.5-7B without per model recomputation, decoupling selection from the target model. These results demonstrate that a single, transferable selector provides an effective and reusable solution for efficient multimodal instruction tuning.
arXiv:2605.29219v2 Announce Type: replace
Abstract: Interaction between humanoids involves bidirectional and nonverbal reactivity, coordination and synchrony. Toward socially aware robots and interactive virtual agents, we present SalsaAgent, a language model that generates expressive, full-body salsa dance motions in reaction to a human leader and against a contextual music backdrop. We formulate interaction as nonverbal motion token passing, extending the vocabulary of a large language model (LLM) to process discrete motion tokens, pairwise relation tokens, and audio. Our contributions include new tokens for full-body and motion relations, LLM fine-tuning using automatically derived text descriptions of skeleton dynamics for token grounding, and a two-stage token-to-diffusion pipeline. Subjective and objective evaluations demonstrate the effectiveness of our approach in terms of motion quality, music and partner coordination, and consistent two-person spatial behavior, with significant improvements over baselines.
arXiv:2606.04463v2 Announce Type: replace
Abstract: We present OSCAR, a precise action-conditioned video world model that generalizes across different robot embodiments and enables robot policy evaluation. Existing video world models face three main challenges for real-world robot evaluation: limited scenario diversity in current robot training datasets, imprecise action following, and poor generalization across embodiments for broad adoption. We tackle these challenges from two perspectives. At its core is a large-scale standardized data pipeline that curates, filters, and deduplicates broad robotics and egocentric human datasets, yielding a clean joint-training dataset that spans diverse tasks, scenarios, actions, and robot embodiments. To condition the video model, we adopt 2D kinematic skeleton rendering as a unified conditioning representation that generalizes across different robot arms or even human hands. We finetune the Cosmos-Predict2.5-2B model on a single GH200 GPU. Our model achieves significant improvement on action following, appearance quality, and motion consistency, compared to existing baselines, which either have a much larger model size or require more GPUs. We further deploy OSCAR to evaluate robot policies from RoboArena. Extensive experiments demonstrate the significant correlation between our virtual policy evaluation in OSCAR and real-world evaluation, paving the way for the future where robot policies can be purely evaluated in virtual generated worlds.
arXiv:2503.04712v3 Announce Type: replace-cross
Abstract: We study the optimization of non-convex functions that are not necessarily smooth (gradient and/or Hessian are Lipschitz) using first order methods. Smoothness is a restrictive assumption in machine learning in both theory and practice, motivating significant recent work on finding first order stationary points of functions satisfying generalizations of smoothness with first order methods. We develop a novel framework that lets us systematically study the convergence of a large class of first-order optimization algorithms (which we call decrease procedures) under generalizations of smoothness. We instantiate our framework to analyze the convergence of first order optimization algorithms to first and \textit{second} order stationary points under generalizations of smoothness. As a consequence, we establish the first convergence guarantees for first order methods to second order stationary points under generalizations of smoothness. We demonstrate that several canonical examples fall under our framework, and highlight practical implications.
arXiv:2310.04649v3 Announce Type: replace
Abstract: We introduce NPEFF (Non-Negative Per-Example Fisher Factorization), an interpretability method that aims to uncover strategies used by a model to generate its predictions. NPEFF decomposes per-example Fisher matrices using a novel decomposition algorithm that learns a set of components represented by learned rank-1 positive semi-definite matrices. Through a combination of human evaluation and automated analysis, we demonstrate that these NPEFF components correspond to model processing strategies for a variety of language models and text processing tasks. We further show how to construct parameter perturbations from NPEFF components to selectively disrupt a given component's role in the model's processing. Along with conducting extensive ablation studies, we include experiments to show how NPEFF can be used to analyze and mitigate collateral effects of unlearning and use NPEFF to study in-context learning. Furthermore, we demonstrate the advantages of NPEFF over baselines such as gradient clustering and using sparse autoencoders for dictionary learning over model activations. We release the code used in this work.
arXiv:2606.06356v1 Announce Type: new
Abstract: Multimodal generative models produce fluent outputs but remain unreliable when generation must respect structured, domain-specific, or safety-critical knowledge. Existing methods incorporate knowledge through mechanisms such as prompt augmentation, guidance, latent editing, or fine-tuning, yet they are typically categorized by technique rather than by the component of the generative process they modify. We argue that knowledge infusion in iterative generative models is fundamentally anintervention-layer problem. Since thegenerative process unfolds as a trajectory of internal states, knowledge can act on four structurally distinct components of this process: the input/output boundary, the transition function, the intermediate state, and the model parameters. This maps to four intervention layers: surface, trajectory, latent, and parametric infusion. We instantiate the framework in diffusion models, map representative methods to all four layers, and derive design principles for multi-layer composition. In a controlled safety-alignment experiment using a multimodal knowledge graph with two diffusion backbones, we implement three of the four layers cumulatively, surface (input-side and output-side) and trajectory--latent (mid-generation). We show empirically that each additional layer addresses failure classes that prior layers cannot reach, reducing knowledge-violating outputs by 70.97% compared to vanilla generation and empirically confirming the framework's complementarity prediction.
arXiv:2606.06366v1 Announce Type: new
Abstract: Real-time autonomous driving commonly relies on sampling-based trajectory planners that link candidate trajectories to target waypoints along the road centerline. The placement of these waypoints directly impacts both the existence and quality of feasible trajectories. Yet, its effect on planner performance remains largely unexplored. In this paper, we treat waypoint placement as a first-class design variable. We hold the trajectory primitive and candidate budget fixed, and systematically sweep three placement strategies (uniform spacing, an augmented Ramer-Douglas-Peucker variant (RDP*), and a novel curvature-conditioned allocation) across 449 configurations and five CommonRoad maps of increasing geometric complexity. Our results show that the nominal inter-waypoint spacing $d_s$ is the primary performance driver, with large differences in planner reliability attributed to placement alone. Uniform sampling at a well-tuned spacing matches or surpasses both RDP* and the centered curvature variant. The curvature variant offers a small but consistent advantage on geometrically complex roads under reliability-first and balanced weightings, while RDP* never outperforms uniform sampling. These findings suggest that $d_s$ should be treated as the dominant tuning parameter, with geometry-aware strategies reserved for curvature-rich corridors where feasibility is the limiting factor.
arXiv:2606.06374v1 Announce Type: new
Abstract: We study the motion of columnar ice crystals that form in clouds over a range of low temperature. Our focus here is on elongated ice crystals, which are smaller than the size of the smallest eddies in the flow, with a moderate aspect ratio comprised between $3$ and $5$. We determine turbulent solutions of the Navier-Stokes equations over a range of turbulent kinetic energy dissipation characteristic of clouds ($4.41\;{\rm cm}^2/{\rm s}^3 \le \varepsilon \le 1120\;{\rm cm}^2/{\rm s}^3$) by using direct numerical simulations, and we follow the motion of crystals using simplified but realistic models for the motion of non-spherical, elongated particles. The influence of the fluid inertia leads to a preferential alignment of the crystals perpendicular to the direction of gravity, the alignment effect being opposed by the turbulent fluctuations. Along with the strong alignment of the crystal axis perpendicular to gravity, we observe only a weak alignment with the vorticity, much weaker than in the absence of gravity. The settling velocity depends only weakly on the orientation of the crystals, but is strongly enhanced when $\varepsilon$ increases, an effect that we attribute to preferential concentration in the flow. As the inertia of the columnar ice crystals considered here is significant, we observe a strong spatial clustering. Finally, we discuss the relevance of the effects identified here on the collision frequency between ice crystals in cloud conditions.
arXiv:2606.06451v1 Announce Type: new
Abstract: There are two common classes of fairness notions that are considered when allocating $m$ indivisible items to $n$ agents of equal entitlements. One is that of share-based fairness notions, with the maximin share (MMS) and its relaxations to $\rho$-MMS being prominent representatives of this class. The other is that of comparison-based fairness notions, with envy-freeness (EF) and its relaxations such as EF1 being prominent representatives of this class. In general, no class offers good guarantees for the other class. In this work, we design allocations that simultaneously satisfy notions from both classes, and specifically, are $\rho$-MMS for constant $\rho$ and EF1 (in fact, also EFL). Such results were previously known when agents have additive valuations, and we prove such results for the more general class of submodular valuations.
arXiv:2606.06459v1 Announce Type: new
Abstract: Next-generation wireless networks are expected to rely on multiple concurrent AI-driven control functions that optimize different network objectives simultaneously, particularly in AI-integrated and open radio access network architectures such as AI Radio Access Network (AI-RAN) and Open Radio Access Network (O-RAN). When these functions interact, they can interfere with one another in ways that are difficult to detect from raw network data alone. A key missing piece for managing such interactions is a reliable, interpretable dependency structure that captures which control parameters are actively influencing which network performance outcomes at any given time. This paper focuses on the event-detection step needed to support such dependency learning by converting noisy continuous telemetry into binary indicators of parameter activity and KPI response. The central difficulty is that not every fluctuation in the data reflects a genuine control interaction, so the method must distinguish real parameter-outcome relationships from background variation. Because real AI-RAN traffic traces with known parameter-KPI ground truth are difficult to obtain, we introduce a synthetic closed-loop traffic generator with planted latent dependencies. We use this controlled telemetry to evaluate a machine-learning-based dependency recovery pipeline that formulates the conversion of continuous traces into binary event indicators as a significance-detection problem. Experimental evaluation shows that the proposed pipeline reliably recovers the latent dependency structure from noisy continuous traces when the signal is sufficiently separated from background variation, while highlighting threshold calibration as the key factor controlling event-detection quality. These results constitute a foundational step toward interpretable dependency learning for adaptive AI-RAN control systems.
arXiv:2606.06474v1 Announce Type: new
Abstract: Discrete diffusion language models generate text by iteratively denoising an entire response in parallel. At each step, they predict tentative tokens for every masked position, committing the confident predictions to the output and discarding the unconfident ones. We show that the discarded tokens are in fact a useful lookahead signal for retrieval-augmented generation: even low-confidence tokens often surface salient entities early in the denoising trajectory, enabling retrieval of stronger evidence before the output is finalized. We exploit this through Self-Augmenting Retrieval for Diffusion Language Models (SARDI), a dynamic RAG framework that uses these lookahead tokens to guide retrieval during denoising. SARDI is training-free, retriever-agnostic, and applicable to any reasoning-capable discrete diffusion language model. Across five multi-hop QA benchmarks, SARDI outperforms current training-free diffusion and autoregressive retrieval baselines at up to $8\times$ higher throughput.
arXiv:2606.06476v1 Announce Type: new
Abstract: While Vision-Language Models (VLMs) have shown strong visual reasoning capabilities, their spatial reasoning abilities remain largely constrained to the observed images and text-oriented chain-of-thought. They often struggle to infer unobserved layouts, maintain cross-view consistency, and reason from alternative viewpoints when only limited egocentric observations are available. In this work, we study this problem as thinking with imagination, where a VLM actively acquires imagined visual evidence by interacting with a world simulator during reasoning. We propose Astra, an agentic spatial reasoning framework that empowers VLMs with action-conditioned visual imagination. Specifically, Astra couples Astra-VL, an RL-trained VLM policy, with Astra-WM, a Bagel-based world simulator that generates novel-view observations from context images and natural-language camera motions. To provide reliable imagined evidence, Astra-WM is trained with view consistency tuning to improve pose and content consistency across views. In the RL stage, we propose a world-simulator-in-the-loop two-phase RL curriculum to stabilize tool-use exploration and advance the model's ability to invoke the simulator only when imagined observations improve over direct answering. Experiments demonstrate that both the world simulator and the agentic policy are necessary: Astra-WM improves simulator-augmented Gemini-3-Flash on MMSI-Bench from 45.1 to 49.5, while Astra-VL improves the Qwen3-VL backbone from 29.8 to 38.8 on MMSI-Bench and from 36.8 to 42.7 on MindCube. These results show that imagined observations can provide useful spatial evidence, but effective world-model-augmented reasoning requires learning when, where, and how to imagine.
arXiv:2606.06477v1 Announce Type: new
Abstract: Standard continuous-time generative models rely on monolithic architectures that must navigate vastly different signal regimes, from isotropic noise to intricate data distributions. While scaling model capacity improves performance, deploying a massive network uniformly across the entire generative timeline is inherently inefficient. In this work, we propose Complexity-Balanced Splitting (CBS), a principled framework for temporal capacity allocation that distributes the generative workload across multiple specialized sub-networks. Grounded in function approximation theory and de Boor's equidistribution principle, CBS partitions the diffusion timeline into segments of equal approximation burden, allocating more representational capacity to regions where the generative dynamics are more difficult to model. To estimate this local complexity, we introduce two complementary and tractable monitor functions: a spatial measure based on the flow's Dirichlet energy, and a geometric measure based on the acceleration of the sampling trajectories. Using a lightweight auxiliary model to estimate these complexity profiles, our approach eliminates the need for heuristic temporal splits or computationally expensive search procedures. Extensive evaluation across multiple architectures (SiT, JiT, and UNet) and datasets demonstrates that CBS consistently improves synthesis quality without increasing per-step inference cost. In particular, CBS improves FID by ~35% on SiT-XL with CFG relative to naive temporal partitioning. Project page is available at https://noamissachar.github.io/CBS/.
arXiv:2606.06479v1 Announce Type: new
Abstract: Training recurrent neural networks (RNNs) requires assigning credit across long sequences of computations. Standard backpropagation through time (BPTT) addresses this problem poorly: it is sequential in time, limiting parallelism, and suffers from vanishing or exploding gradients, making long-range associations difficult to learn. We propose Supervised Memory Training (SMT), a method for training nonlinear RNNs that sidesteps recurrent credit propagation entirely by reducing RNN training to supervised learning on one-step memory transition labels $(m_t, x_{t+1}) \rightarrow m_{t+1}$. SMT acquires these memory labels by training a Transformer-based encoder on a predictive state objective--retaining only information from the past necessary to predict the future. By decoupling what to remember from how to update memory, SMT enables time-parallel RNN training with a stable $O(1)$ length gradient path between any two tokens--without ever unrolling the RNN. We find that SMT outperforms BPTT when pretraining various RNN architectures on tasks like language modeling and pixel sequence modeling. SMT enables nonlinear RNNs to better capture long-range dependencies and train in parallel, potentially unlocking the scaling of models that build temporal abstractions of past experience.
arXiv:2605.03362v1 Announce Type: cross
Abstract: Neuromechanics aims to understand the link between an animal's neural activity and its physical behaviors. Recent advances in experimental and machine learning techniques enable simultaneous recordings of neural and locomotion dynamics over long time periods and across multiple behavioral transitions in worms, flies, and other organisms. These high-dimensional datasets present the challenge of inferring interpretable low-dimensional dynamical models that quantitatively connect neural activity and behavioral dynamics. However, despite major experimental and theoretical progress, there is currently no end-to-end model for predicting locomotion and other behaviors from neural activity. Here, we present a theoretical and computational framework for inferring multiscale neuromechanical models from state-of-the-art experimental data. Our data-efficient approach combines interpretable spectral mode representations with Helmholtz-Nambu decompositions and Bayesian inference to identify a predictive stochastic model that converts neural activity time series into behavioral locomotion patterns. We first apply this framework to recently published recordings of neural activity and locomotion in the roundworm Caenorhabditis elegans, showing that it accurately describes experimentally observed dynamics. We further demonstrate how the inferred model can be used to predict neural activation patterns for controlling C. elegans locomotion in real time, providing a basis for future optogenetic experiments. Due to its generic formulation, the framework introduced here is broadly applicable to neuromechanical recordings for a wide range of animal species.
Ontology-constrained multi-LLM scoring of hypothesis support in the predictive processing literature
arXiv:2606.05206v1 Announce Type: cross
Abstract: Fragmentation is common in interdisciplinary fields with diverse methods and theoretical commitments. Predictive coding neuroscience is a clear example: its literature spans computational theory, electrophysiology, imaging, behavior, and modeling, creating a synthesis problem that conventional meta-analysis cannot easily resolve. Here, we describe a local multi-LLM pipeline for ontology-constrained literature synthesis. The pipeline reads papers, extracts evidence, incorporates figure descriptions, assembles constrained prompts, and validates outputs against an expert glossary. We manually defined a predictive-coding glossary of thirty-six concepts grouped into three hypotheses: predictive suppression, feedforward error propagation, and ubiquity. A council of ten local language models scored 31 studies according to their agreement or disagreement with each glossary factor across local and global oddball contexts. This enabled pairwise study-agreement analysis, cross-model comparison, and three-dimensional hypothesis-space mapping. Agreement was high for some hypotheses but weaker for others, revealing structured disagreement, particularly across local versus global oddball paradigms. We further define hypothesis-space temperature, a geometric dispersion metric measuring how compactly studies occupy the hypothesis space. Temperature was lower for local oddball contexts and higher for global oddball contexts, indicating greater dispersion in the latter. The scoring geometry also allowed us to estimate vectors of change between experimental contexts. These results demonstrate that local multi-LLM councils can produce auditable disagreement measurements that map heterogeneous literatures into quantitative evidence spaces. This framework may generalize to cross-study hypothesis mapping where conventional meta-analysis lacks a common comparison space.
arXiv:2606.05227v1 Announce Type: cross
Abstract: Hereditary stomatocytosis (HS) comprises red blood cell (RBC) disorders characterized by cup-shaped erythrocytes that respond oppositely to splenectomy: curative in overhydrated HS (OHS) but potentially thrombogenic in dehydrated HS (DHS/xerocytosis). This paradox persists because RBC biomechanics is governed by partly independent parameters--shear modulus, bending rigidity, surface-to-volume ratio (S/V), and cytoplasmic viscosity--that existing assays capture only piecemeal. Here we combine dissipative particle dynamics (DPD) simulations with microfluidic imaging to construct a control discocyte and three stomatocyte models (ST-RBC1-3) at fixed membrane area and decreasing volume (109.7, 101.5, 89.8 fL), spanning the OHS-to-DHS range. Tracing this parameter set through five mechanically orthogonal assays, we find that interendothelial-slit (IES) traversal is geometry-dominated: overhydrated ST-RBC1 requires an order of magnitude higher critical pressure than healthy RBCs, whereas dehydrated ST-RBC3 passes freely. ST-RBC3 nonetheless suppresses membrane tank-treading and raises low-shear whole-blood viscosity by ~29% at physiological haematocrit, comparable to Gaucher-disease hyperviscosity. A funnel-obstacle chip amplifies these differences into a label-free centerline-offset signal predicted to separate all four RBC types (~4.5 standard deviations between extreme phenotypes). These results unite single-cell mechanics, splenic filtration, and hemorheology in one framework, resolve the splenectomy paradox, and point toward microfluidic pre-operative risk stratification in HS.
arXiv:2606.05361v1 Announce Type: cross
Abstract: Missing data imputation in large-scale surveys faces two challenges that are not well handled by current tabular diffusion methods. First, \emph{structural skips}, cells made inapplicable by questionnaire design, should not be imputed but are often conflated with item nonresponse. Second, \emph{ordinal} responses encode ordered categories, yet most pipelines treat them as nominal levels through one-hot or analog-bit encodings. We introduce \textbf{TabSODA} (\textbf{Tab}ular diffusion with \textbf{S}kip pattern detection and \textbf{O}r\textbf{d}inal \textbf{A}wareness), an Expectation-Maximization (EM)-based diffusion imputer built on the Elucidated Diffusion Model (EDM) framework. TabSODA propagates structural skips through the denoising loss and reverse-time sampler, and represents ordinal variables with cumulative-probit scalar latents while retaining analog-bit encodings for nominal variables. When a codebook skip mask is available, TabSODA uses it directly; otherwise, the TabSODA+SKIP variant estimates the mask from raw responses and questionnaire order using a CART-based skip-pattern miner. On Population Assessment of Tobacco and Health (PATH) study and the National Survey on Drug Use and Health (NSDUH), two nationally representative U.S.\ surveys, TabSODA reduces ordinal MACE by up to $23.7\%$ and improves categorical accuracy by up to $9\%$ over the strongest baseline across MCAR, MAR, and MNAR masking. The skip miner achieves near-perfect precision on both datasets, allowing TabSODA+SKIP to closely track the codebook-mask variant.
arXiv:2606.05365v1 Announce Type: cross
Abstract: We consider multi-environment prediction problems. We assume the environments change the distribution of a latent variable, while the mechanisms generating observed covariates and targets remain stable conditional on that variable. For example, hospitals or clinical cohorts may differ in the prevalence of latent patient states, even though the relationships between those states, physiological measurements, and outcomes remain unchanged. Given a dataset from multiple environments, we formulate a Bayesian model for such problems and derive the corresponding variational objective. We show that this objective decomposes into per-environment terms and an additional cross-environment balancing term induced by the model's structure. We use an empirical Bayes method to set the prior and incorporate it into the objective. Based on this objective, we develop an amortized variational algorithm for posterior approximation, and use the resulting learned latent variables to form predictions in new environments.We study our approach through simulations and real-world studies of astronomical source identification, microbiome-based disease detection, and ICU sepsis prediction. Across these settings, our method outperforms previous approaches for prediction in new environments.