Science Journals

This randomized clinical trial compares the effects of a theory-based serious game (a purpose-driven video game) vs usual education on emergency physician adherence to trauma triage guidelines for older adults.

The study aimed to determine whether a theory-based serious game could improve emergency physician adherence to trauma triage guidelines for severely injured older adults in nontrauma centers.

A new bill would cap US insulin costs under private insurance.

Poor sense of smell was associated with physical function decline in older adults, according to research published in JAMA Otolaryngology − Head & Neck Surgery.

Oral semaglutide was associated with sustained improvements in multiple cardiovascular disease (CVD) risk factors, according to research published in JAMA Cardiology.

In Reply In their Letters, Dr Boujenah and Dr Hnid detail unmeasured variables that may have influenced the exposures and outcomes in our recent electronic health record–based study of GLP-1RA use and discontinuation before and in early pregnancy.

To the Editor Positive end-expiratory pressure (PEEP) titration has long been proposed as a strategy to reduce postoperative pulmonary complications. Large randomized trials, including PROVHILO and PROBESE, failed to demonstrate benefit from standardized higher intraoperative PEEP, highlighting the limitations of fixed approaches. In the recent Driving Pressure During General Anesthesia for Open Abdominal Surgery (DESIGNATION) trial, the investigators tested an individualized, driving pressure–guided PEEP strategy (driving pressure = plateau pressure − PEEP) during open abdominal surgery. A small but measurable separation of pulmonary mechanics was achieved between groups, although no reduction in postoperative pulmonary complications was observed.

In Reply The Letters from Dr Mietto and colleagues, Drs Qi and Zhang, and Mr Yang and colleagues question our findings from the DESIGNATION trial, arguing that intermittently scheduled PEEP titration may not reflect dynamic intraoperative physiology, high PEEP may impose hemodynamic harm in the highest-risk patients, and the recruitment maneuver and driving pressure measurement may have been methodologically or physiologically inadequate.

For people with certain apolipoprotein E (APOE) genotypes at increased risk of Alzheimer disease, higher meat consumption may be associated with reduced cognitive decline, a study of a cohort in Sweden found.

This Medical News article discusses the potential for the antidepressant mirtazapine to treat methamphetamine use disorder.

JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, spoke with Viktor H. Ahlqvist, PhD, a postdoctoral fellow in the Unit of Integrative Epidemiology of the Institute of Environmental Medicine at Karolinska Institutet, for JAMA+ AI Conversations.

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, with an estimated 150 000 new cases annually worldwide. Patients with DLBCL typically require treatment at the time of diagnosis, and more than 60% of patients are currently cured with front-line immunochemotherapy such as R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). However, DLBCL is highly heterogeneous, and subsets of patients who progress after front-line treatment have a substantially poorer clinical outcome. Therapeutic progress to improve the outcome of the patients with lymphoma destined to progress after initial chemotherapy has proven very difficult, with very few trials showing superiority of an experimental group over standard R-CHOP.

This study uses data from the National Vital Statistics System to examine quarterly suicide mortality among individuals aged 15 to 34 years.

This randomized clinical trial conducted in China evaluates the efficacy and safety of the histone deacetylase inhibitor tucidinostat plus R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) vs R-CHOP alone as first-line treatment for patients with MYC/BCL2 double-expressor lymphoma.

This study aimed to assess whether adding the histone deacetylase inhibitor tucidinostat to rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) improves clinical outcomes in patients with newly diagnosed MYC/BCL2 double-expressor lymphoma.

This study analyzes US state actions taken in 2025 that strengthened or weakened COVID-19 vaccination infrastructure and access.

This Review summarizes the current evidence for prepregnancy care and counseling with a primary care focus.

Naming is essential in medicine. Medical terminology allows clinicians to document and communicate and, most importantly, make diagnoses. A feeling of control can come from arriving at that perfect word that unifies each of a patient’s specific medical findings. However, even the most skilled clinician may still be left speechless when confronting the enormity of at once obvious, and yet unspeakable, mortality. The esteemed poet W. H. Auden famously asserted, “…poetry makes nothing happen” in his 1939 poem “In Memory of W. B. Yeats.” “On Mortality” reminds us of the same insufficiency of language, not just medical language but even poetry, as the speaker grasps at the right words to describe the end of life. The chastened clinician relies on found objects and simple observations to convey what even the most astute diagnosis cannot. As moving as these are—the back massage never received, the routinization of intensive care unit deaths—by the last stanza, the speaker finally relinquishes the attempt to explain mortality, surrendering to the realization that “too many words” only defeat such efforts. This ironically lapidary poem offers an interesting reflection for clinicians—what do we say when we feel but cannot fully describe something we witness? Thus poetry, with its comfort with silences and concision, arises in addition to medical vernacular. Poetry, by eliciting pure feeling, can allow the reader to experience awe at the human condition when accurate diagnosis, or even just the right word, seems elusive.

This Viewpoint discusses the chasm between current US health care and a vision of more comprehensive, equitable, and patient-centered care and proposes actionable strategies to bridge that chasm.

This Perspective discusses the use of bayesian methods in clinical trials and the importance of having US Food and Drug Administration (FDA) guidance that provides substantive insights about the methods’ proper role.

This Perspective discusses the draft guidance for industry that the US Food and Drug Administration released on the use of bayesian methods in testing therapeutics.

This JAMA Clinical Guidelines Synopsis summarizes the 2024 recommendations from the American Heart Association and American College of Cardiology on perioperative cardiovascular medication management for noncardiac surgery.

Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.

This JAMA Patient Page describes metabolic dysfunction–associated steatotic liver disease (MASLD) and its risk factors, symptoms and complications, diagnosis, and treatment.