Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10490-ySystems-level analyses of organ intrinsic nervous systems reveal that these networks are initially configured by lineage-dependent programmes, and their architecture and molecular identity are refined by intra-organ specific local cues.
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10530-7High-resolution in situ cryo-electron tomography in Schizosaccharomyces pombe identifies SNOR protein, which binds to ribosomes during dormancy induced by glucose depletion, priming them for rapid reactivation of protein synthesis upon glucose repletion.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10431-9Electron-beam control enables deterministic placement of tens of thousands of atomic defects in three-dimensional crystals, creating stable, programmable artificial matter for scalable quantum and nanoscale technologies.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10481-zHippocampal–neocortical communication reconfigures predetermined circuit motifs to flexibly encode experiences.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10465-zAn analysis of 5,778 domains 28–64 amino acids in length reveals hidden variation in conformational fluctuations, even between sequences sharing the same fold and global folding stability.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10489-5Structured liquid droplets exhibit asymmetric division in the absence of reconstituted protein machinery.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10524-5A cross-organ, multi-omics U-shaped relationship between sleep duration and biological ageing clocks highlights the potential of sleep optimization to promote healthy ageing, lower disease risk and extend longevity.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10491-xMachine learning analysis of cell-type-specific gene expression in mouse and human neocortex and human cortical organoids reveals human-specific cell-type and temporal variations in expression controlled by JUNB.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10383-0Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10531-6From pregnancy until lactation, eosinophils accumulate in the small intestine where they regulate goblet cell fate and enhance innate defences against enteric pathogens.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10510-xCombining a computational framework and optogenetic and chemogenetic manipulations within and downstream of the cortico-basal ganglia circuit identifies the specific cortico-basal ganglia synapses that drive the acquisition and expression of rapid vocal changes during juvenile song learning.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10515-6PTCHD1-AS, which encodes a long non-coding RNA, is associated with the aetiology of autism spectrum disorder in humans through striatal molecular and circuit-level dysregulation.
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10454-2Integration of data representing 35,120 brain scans from diverse global studies enables construction of reference charts that define normative microstructural and macrostructural properties across the human lifespan for research and clinical diagnosis.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01374-2Limited access to medical professionals and irresponsible prescribing practices are contributing to antimicrobial resistance in low-resource settings.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01379-xThe last antimicrobial peptide was developed decades ago. Now, drug-resistant bacteria are forcing scientists to take a fresh look at this class of antibiotic.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01485-wObservations from the James Webb Space Telescope reveal that extremely fast, galaxy-scale outflows from luminous objects called quasars were much more frequent, and on average more powerful, about one billion years after the Big Bang than at later cosmic epochs. These outflows could easily escape their host galaxies and regulate the evolution of early massive galaxies.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01506-8Health outcomes were better in people who slept for between about six and eight hours a day.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01318-wStudies of white matter — the tissue used for communication between brain regions — have revealed substantial changes in people with neurological diseases and disorders. The creation of white-matter brain charts enables individual deviations from the typical structure to be assessed using magnetic resonance imaging (MRI) brain scans.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01139-xYulu Hou and her partner experimented with using ChatGPT to automate marking of undergraduate assignments. Here’s what they learnt.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01532-6Genetic analysis suggests interbreeding between two groups of human relatives.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01372-4Microbiologist Alexander Fleming’s 80-year-old advice is still key to protecting the efficacy of antibiotics.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01476-xScientists are debating whether to limit biological AI software to ward off threats.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01377-zAntibiotic use in agriculture threatens the health of workers and their communities, but there are potential solutions.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01375-1Medical microbiologist Heiman Wertheim explains why the physical appearance and labelling of antibiotics matter when trying to limit resistance.
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01561-1Data from the 2.8-kilometre-deep core stretches back 1.2 million years. Plus, the cost of using AI tools in the lab and the greatest physics mysteries that still divide researchers.