New mathematical framework reimagines how doctors should classify chronic disease
Researchers propose abandoning organ-based disease categories in favor of a geometry-based model that treats chronic illness as a system instability problem. The shift could reshape drug development, clinical trial design, and how insurers evaluate treatment effectiveness across diseases as different as Crohn's disease and breast cancer metastasis.
Originaltitel: The Universal Resonance Model (URM) Foundational Declaration — Version 1.0
This document presents the official Foundational Declaration of the Universal Resonance Model (URM), Version 1.0. URM establishes a geometry-based ontology of disease, defining pathology as a dynamical instability regime in a coupled, multiscale biological system. Rather than focusing on molecular identity or organ-specific classification, the model describes chronic disease behaviour through restoring curvature (λ₁), variance (σ²), temporal persistence (ρ(τ)), phase delay (Δτ), and cross-system coupling (κ). The Reset Index (RI) formalizes instability proximity and defines the temporal conditions under which therapeutic leverage is maximal. This declaration articulates the core ontological and mathematical principles of URM in a concise form and serves as the foundational reference document for the broader URM body of work. This document is conceptually expanded in:The Universal Resonance Model (URM): A Foundational Framework for Chronic Disease Dynamics (DOI: https://doi.org/10.5281/zenodo.18698512)