New drug conjugates harness cell recycling to destroy cancer proteins

Researchers have developed a new class of drugs that hijack lysosomes—the cell's waste-disposal system—to selectively destroy disease-causing proteins and enable combination therapies. The approach could expand treatment options for cancers and other diseases where existing drugs have failed, potentially opening a new market for precision therapeutics.

Originaltitel: Multibody-Enabled Lysosome-Targeting Drug Conjugates for Target Protein Degradation and Combination Therapy