Chemists crack single-step recipe for high-purity chiral catalysts
Researchers have simplified production of a specialized titanium catalyst used in pharmaceutical and polymer manufacturing, cutting synthesis to one step with 97% purity. The breakthrough reduces production complexity for industrial chemistry, potentially lowering costs and accelerating development of asymmetric synthesis—a technique critical for making active pharmaceutical ingredients.
Originaltitel: Direct Stereoselective Synthesis of a Single (ebthi)Ti(BINOLate) Catalyst Enantiomer
Despite their prominence as privileged chiral catalysts for synthesis and polymer chemistry, the synthesis of enantiopure ebthi-type titanocenes is a challenging task. In this proof-of-concept study, we report the development of a single-step synthesis of (S,S,S)-(ebthi)Ti(BINOLate) from Li2(ebthi) and (S)-Ti(BINOLate)Cl2 in 28% yield with 97% ee. We further shed light on the nature of the latter and provide alternative protocols for the convenient liberation of (S)-(ebthi)TiCl2. (ebthi)-Ti(BINOLate) is further shown to be a competent catalyst in asymmetric ketone-nitrile couplings, providing an enantioselectivity comparable to that of (ebthi)TiCl2.