Scientists unlock hidden drug targets by mapping unexploited protein pockets

Researchers developed new computational methods to identify and assess "cryptic pockets" on proteins—hidden molecular binding sites that were previously invisible to drug discovery. The advance could expand the pipeline of targetable proteins for pharmaceutical companies, potentially opening thousands of new drug development opportunities where traditional approaches found dead ends.

Originaltitel: Enhanced sampling and ligandability assessment to expand the repertoire of potentially druggable cryptic pockets