Fish roe compound shows promise in reversing psoriasis inflammation
Researchers found that phospholipids from herring roe trigger cells to produce anti-inflammatory molecules that suppress psoriasis-like skin reactions in laboratory models. The finding could lead to new dietary or topical treatments for a chronic disease affecting millions globally—a potentially valuable market for pharma and nutraceutical companies.
Originaltitel: Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast coculture as a model of psoriasis
AA (arachidonic acid), AcOH (acetic acid), AIM-V (AIM-V medium), ALOX12 (arachidonate 12lipoxygenase), ALOX15 (arachidonate 15-lipoxygenase), ALOX15B (arachidonate 15-lipoxygenase type B), ALOX5 (arachidonate 5-lipoxygenase), ANOVA (analysis of variance), B2M (beta-2 microglobulin), C18 (octadecyl silica gel), CCL2 (chemokine ligand 2), cDNA (complementary DNA), COX2 (cyclooxygenase-2), CTS (Cell Therapy Systems), CYP450 (cytochrome P450), DHA (docosahexaenoic acid), DM (dry matter), DMEM (Dulbeccos modified Eagles medium), DPA (docosapentaenoic acid), EF1A (eukaryotic translation elongation factor 1 alpha), EPA (eicosapentaenoic acid), Et2O (diethyl ether), EtOH (ethanol), FA (fatty acid), FBS (fetal bovine serum), FID (flame ionization detector), GAPDH (glyceraldehyde-3-phosphate dehydrogenase), GC (gas chromatography), GC-FID (gas chromatographyflame ionization detector), GPCR (G proteincoupled receptor), GPX4 (glutathione peroxidase 4), HDHA (hydroxydocosahexaenoic acid), HDPA (hydroxydocosapentaenoic acid), HEPE (hydroxyeicosapentaenoic acid), HETE (hydroxyeicosatetraenoic acid), HPLC (high-performance liquid chromatography), HPRT1 (hypoxanthine phosphoribosyltransferase 1), HRO (herring roe oil), HSD (honestly significant difference), ICSR (Immune Cell Serum Replacement), IFN- (interferon gamma), IFN-R1 (interferon gamma receptor 1), IHR (immature herring roe), IL (interleukin), IL-17 (interleukin 17), IL-17A (interleukin 17A), IL-23 (interleukin 23), IMID (immune-mediated inflammatory disease), IS (internal standard), LC-MS/MS (liquid chromatography-tandem mass spectrometry), LC-PUFA (long-chain polyunsaturated fatty acid), LLOQ (lower limit of quantification), LPS (lipopolysaccharide), LTB4 (leukotriene B4), LTC4 (leukotriene C4), LTD4 (leukotriene D4), LTE4 (leukotriene E4), LXA4 (lipoxin A4), MaR1 (maresin 1), MaR2 (maresin 2), M-CSF (macrophage colony-stimulating factor), MDM (monocyte-derived macrophages), MeOH (methanol), mRNA (messenger RNA), MRM (multiple reaction monitoring), NFKBIZ (NF-B inhibitor zeta), NMR (nuclear magnetic resonance spectroscopy), PASI (psoriasis area severity index), PBMC (peripheral blood mononuclear cells), PC (phosphatidylcholine), PCR (polymerase chain reaction), PCTR (protectin conjugate in tissue regeneration), PCTR1 (protectin conjugate in tissue regeneration 1), PCTR2 (protectin conjugate in tissue regeneration 2), PCTR3 (protectin conjugate in tissue regeneration 3), PD1 (protectin D1), PD1n-3 DPA (n-3 docosapentaenoic acid-derived protectin D1), PDX (protectin DX), PEHeRo (phospholipid esters from herring roe), Pen-Strep (penicillin and streptomycin), Ph.Eur.(european pharmacopoeia), PGE3 (prostaglandin E3), PLA2 (phospholipase A2), PL (phospholipid), PLS-DA (partial least-squares discriminant analysis), PMN (polymorphonuclear leukocytes), PUFA (polyunsaturated fatty acid), qPCR (quantitative PCR), QTrap (quadrupole ion trap), RBC (red blood cell), REK (regional ethics committee), RNA (ribonucleic acid), RPOL2 (RNA polymerase 2), RvD1 (resolvin D1), RvD2 (resolvin D2), RvD3 (resolvin D3), RvD4 (resolvin D4), RvD5 (resolvin D5), RvD5n-3 DPA (n-3 docosapentaenoic acidderived resolvin D5), RvD6 (resolvin D6), RvE1 (resolvin E1), RvE2 (resolvin E2), RvE3 (resolvin E3), RvE4 (resolvin E4), RvT1 (resolvin T1), RvT2 (resolvin T2), RvT4 (resolvin T4), S100A7 (psoriasine), SEM (standard error of the mean), SPE (solid-phase extraction), SPM (specialized proresolving mediators), TAG (triacylglycerol), TLC (thin layer chromatography), UV (ultraviolet), VIP (variable importance in projection), 17R-PD1 (17(R)-PD1), 17S-HpDHA (17S-hydroperoxy-DHA)