Chemists Develop New Method to Build Complex Drug Molecules
Researchers have cracked a tricky chemical reaction that could accelerate development of fluorine-containing drugs used in cancer and other treatments. The copper-catalyzed process achieves unprecedented precision in building molecular bonds, though scientists must still solve a yield problem before the method moves into pharmaceutical manufacturing.
Originaltitel: Stereoselective Copper-Catalyzed Cross-Coupling of α-CF<sub>3</sub>-Allylboronic Acids with Diazoketones
<p>We have studied copper-catalyzed cross-coupling of chiral α-CF<sub>3</sub>-substituted allylboronic acids with α-diazoketones. The reaction proceeds with excellent regioselectivity and stereoselectivity via allylic rearrangement. The method is useful for formation a new allylic C(sp<sup>3</sup>)–C(sp<sup>3</sup>) bond with high selectivity. The poor yield is a limitation of this reaction.</p>