Personalized breathing support cuts guesswork in critical care
A new study shows doctors can fine-tune ventilator settings to match individual lung damage patterns, improving outcomes in acute lung injury. The finding could standardize ICU care and reduce complications in critically ill patients—a significant cost reducer for hospitals managing severe respiratory failure.
Originaltitel: Individualized PEEP can improve both pulmonary hemodynamics and lung function in acute lung injury
<p>Rationale There are several approaches to select the optimal positive end-expiratory pressure (PEEP), resulting in different PEEP levels. The impact of different PEEP settings may extend beyond respiratory mechanics, affecting pulmonary hemodynamics. Objectives To compare PEEP levels obtained with three titration strategies-(i) highest respiratory system compliance (C-RS), (ii) electrical impedance tomography (EIT) crossing point; (iii) positive end-expiratory transpulmonary pressure (P-L)-in terms of regional respiratory mechanics and pulmonary hemodynamics. Methods Experimental studies in two porcine models of acute lung injury: (I) bilateral injury induced in both lungs, generating a highly recruitable model (n = 37); (II) asymmetrical injury, generating a poorly recruitable model (n = 13). In all experiments, a decremental PEEP titration was performed monitoring P-L, EIT (collapse, overdistention, and regional ventilation), respiratory mechanics, and pulmonary and systemic hemodynamics. Measurements and main results PEEP titration methods resulted in different levels of median optimal PEEP in bilateral lung injury: 14(12-14) cmH(2)O for C-RS, 11(10-12) cmH(2)O for EIT, and 8(8-10) cmH(2)O for P-L, p < 0.001. Differences were less pronounced in asymmetrical lung injury. PEEP had a quadratic U-shape relationship with pulmonary artery pressure (R-2 = 0.94, p < 0.001), right-ventricular systolic transmural pressure, and pulmonary vascular resistance. Minimum values of pulmonary vascular resistance were found around individualized PEEP, when ventilation distribution and pulmonary circulation were simultaneously optimized. Conclusions In porcine models of acute lung injury with variable lung recruitability, both low and high levels of PEEP can impair pulmonary hemodynamics. Optimized ventilation and hemodynamics can be obtained simultaneously at PEEP levels individualized based on respiratory mechanics, especially by EIT and esophageal pressure.</p>