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New data could boost production of cancer-fighting radioactive isotope

Scientists at CERN have mapped how neutrons interact with ytterbium-176 to produce lutetium-177, a radioactive isotope increasingly used in cancer treatments. The high-resolution measurements resolve nuclear resonances for the first time, providing pharmaceutical manufacturers and nuclear medicine facilities with better data to optimize production routes and meet surging demand.

Originaltitel: Measurement of the <sup>176</sup>Yb⁢(𝑛,𝛾) cross section at the n_TOF facility at CERN

Abstrakt

<p><strong>Background:</strong> The <sup>176</sup>Yb⁢(𝑛,𝛾)⁢<sup>177</sup>Yb→<sup>177</sup>Lu reaction is of interest in nuclear medicine as it is the preferred production route for 177Lu. This radioisotope has seen a very fast growth of usage in nuclear medicine in recent years due to its outstanding properties. New data on this reaction could provide useful information for production at new facilities.</p><p><strong>Purpose:</strong> We aim to resolve resonances in the <sup>176</sup>Yb⁢(𝑛,𝛾)⁢<sup>177</sup>Yb reaction for the first time. Previous capture measurement provided data at thermal point and encompassed integral measurements in the range from 3 keV to 1 MeV, where three time-of-flight measurements are available, but with low resolution to resolve the resonances. Transmission measurements from the 1970s resolved and analyzed some resonances.</p><p><strong>Method:</strong> We measure the neutron capture cross section of <sup>176</sup>Yb⁢(𝑛,𝛾)⁢<sup>177</sup>Yb by means of the time-of-flight technique at the Experimental Area 1 of the n_TOF facility at CERN using an enriched <sup>176</sup>Yb<sub>2</sub>⁢O<sub>3</sub> sample and an array of four C<sub>6</sub>⁢D<sub>6</sub> liquid scintillation detectors.</p><p><strong>Results:</strong> We have resolved 164 resonances up to 21 keV, including 96 new ones. We also provide new capture experimental data from 90 eV to 3 keV, and we extend the resolved resonance region up to 21 keV. In addition, resonance decay widths, Γ<sub>𝛾</sub> and Γ<sub>𝑛</sub>, are provided for all resonances together with resonance energies.</p><p><strong>Conclusions:</strong> The <sup>176</sup>Yb⁢(𝑛,𝛾)⁢<sup>177</sup>Yb reaction has been measured, providing resonance parameters for the first time from a few eV to 21 keV. The analysis of the resonances has been carried out and compared with previous works and existing libraries, revealing discrepancies due to the new information on Γ<sub>𝛾</sub> parameters. Our results are consistent with the Γ<sub>𝑛</sub> parameters obtained in transmission measurements.</p>

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