Scientists design gold compounds that could unlock new drug manufacturing
Researchers have synthesized a new class of gold-based chemical compounds with unusual structural properties that could accelerate production of pharmaceuticals and materials. The findings reveal how to reliably control the arrangement of gold complexes in solid form—a capability that manufacturers need to scale up promising drug candidates from lab to market.
Originaltitel: Synthesis and characterization of<em> cis</em>-bisdiphenylphosphinoethene gold(I) complexes
<p>A series of solid-state structures of gold(I) complexes using the semi-rigid cis-1,2- bis(diphenylphosphino)ethene (= cis-bdppe) ligand are reported. The proximity of the phosphine donor atoms of the bidentate ligand framework greatly favors formation of mononuclear over di nuclear complexes. Structural analysis and theoretical studies shed further light on counter intermolecular packing motifs in the solid state including interactions of solvent, ligand and counterion fragments.</p>