Life Sciences
4.4
How DNA-Searching Proteins Navigate Shapes the Outcome
Scientists have discovered that the path chromatin remodelers take along DNA determines how nucleosomes—the protein spools that package genes—will move. The finding could improve drug development and gene therapy by revealing how cells regulate which genes get expressed, a critical factor in disease and aging.
Originaltitel: The voyage is as important as the harbor
Abstrakt
<p>To find nucleosomes, chromatin remodelers slide and hop along DNA, and their direction of approach affects the direction that nucleosomes slide in.</p>