Women Born Premature Face Lower Odds of Having Children

<p>Objective To evaluate if the reduced likelihood of reproducing among women born small for gestational age (SGA), preterm (PT) or with low birth weight (LBW) persists towards the end of their reproductive era and to evaluate their use of medically assisted reproduction (MAR). Design Population-based register study. Setting Sweden. Population/Sample Women born in Sweden between 1973 and 1993 (n = 1 000 148). Methods Data was retrieved from registers, among others the Swedish Medical Birth Register. The study population was stratified into two cohorts, born 1973 to 1983 and 1984 to 1993. The likelihood of giving birth was analysed using a Cox Proportional Hazards model. Main Outcome Measures Giving birth to at least one child. Results Women born SGA, PT or LBW had a lower probability of giving birth (presented as HR), adjusted for sociodemographic factors, with 95% CI: SGA: HR 0.94 (0.93-0.96); PT: HR 0.95 (0.94-0.96); and LBW: HR 0.90 (0.88-0.92) but no reduction was seen for women in the younger cohort born SGA (HR 0.98 [0.95-1.01]). Women born SGA or LBW had a lower chance of childbirth after MAR (SGA 80.3%, LBW 80.0%) compared to women born with normal weight (84.6%, p &amp;lt; 0.001) as well as an increased risk of being treated with oocyte donation (SGA 5.5% vs. 2.5%, p &amp;lt; 0.001; LBW 5.0% vs. 2.5%, p &amp;lt; 0.001). Conclusion The decreased probability of parenthood for women born LBW, SGA, or preterm was even more evident after a longer follow-up time. When pursuing MAR with their own oocytes, they had a lower chance of conceiving.</p>