New genetic mutation linked to aggressive childhood leukemia could reshape treatment

Researchers identified a previously unknown genetic fusion involving CCDC88C and JAK2 genes in a pediatric leukemia case. The discovery could enable earlier diagnosis and guide development of targeted therapies for this rare but deadly blood cancer subtype.

Originaltitel: Case Report: Whole genome sequencing identifies <i>CCDC88C</i> as a novel <i>JAK2</i> fusion partner in pediatric T-cell acute lymphoblastic leukemia