Genetic defects in key immune regulators spark rare but serious infections

Researchers have identified how mutations in two immune system proteins—NF-κB1 and NF-κB2—trigger severe, lifelong immunodeficiency disorders. The finding could reshape how clinicians diagnose mysterious recurrent infections and guide development of targeted therapies for patients currently lacking effective treatment options.

Originaltitel: How do nuclear factor kappa B (NF-κB)1 and NF-κB2 defects lead to the incidence of clinical and immunological manifestations of inborn errors of immunity?