Scientists map how tumor suppressor protein triggers cancer cell death

Researchers identified how Wig-1 protein orchestrates cancer cell destruction by activating p53 target genes. The finding could unlock new drug strategies for tumors that depend on faulty cell death pathways, a major driver of treatment resistance and relapse.

Originaltitel: Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s (vol 33, pg 4407, 2014)