Gene defects fuel aggressive esophageal cancer through immune evasion

Researchers identified how broken DNA repair genes drive mutations and suppress immune cell infiltration in esophageal squamous cell carcinoma, a leading cancer globally. The finding could guide development of therapies that restore immune surveillance—potentially improving outcomes for a disease with historically poor treatment options.

Originaltitel: The effects of altered DNA damage repair genes on mutational processes and immune cell infiltration in esophageal squamous cell carcinoma