How to Make Gene-Silencing Drugs Work Better Against Huntington's

Researchers have identified chemical tweaks that dramatically boost the effectiveness of experimental huntingtin-targeting therapies. The findings could accelerate development of treatments for this fatal neurodegenerative disease and inform design strategies for similar gene-silencing drugs across other diseases.

Originaltitel: Chemical Modifications and Design Influence the Potency of <i>Huntingtin</i> Antigene Oligonucleotides