Gene patterns could predict which children with rare liver disease will deteriorate

Researchers identified genetic markers that distinguish children with alpha-1 antitrypsin deficiency who develop severe liver damage from those who remain stable. The findings could enable earlier intervention and personalized monitoring, potentially reducing costly complications and transplant needs in a rare genetic disorder affecting thousands.

Originaltitel: Fibrosis-Related Gene Profiling in Liver Biopsies of PiZZ α1-Antitrypsin Children with Different Clinical Courses