Key enzyme driving heart disease inflammation identified, offering new treatment target

Researchers have pinpointed a specific enzyme—pyruvate dehydrogenase kinase—that fuels the vascular inflammation underlying atherosclerosis and heart attacks. The discovery opens a path for drug developers to intervene earlier in cardiovascular disease, potentially shifting how companies approach prevention therapies and diagnostic strategies.

Originaltitel: Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk