New immune protein discovery could reshape neuroinflammation drug development

Scientists identified Collectin-12 as a previously unknown target in microglial immune cells, opening a potential new pathway for treating brain inflammation without triggering cell death. The finding could accelerate development of therapies for neurodegenerative diseases and neuroinflammatory conditions that represent a major clinical and commercial opportunity.

Originaltitel: Proteome integral solubility alteration high-throughput proteomics assay identifies Collectin-12 as a non-apoptotic microglial caspase-3 substrate