Kidney disease triggers muscle wasting through unexpected phosphate mechanism

Researchers identified how chronic kidney disease causes severe muscle loss: phosphate depletion in muscle tissue activates a protein that breaks down muscle fibers. The finding could lead to new treatments for sarcopenia, a costly condition affecting millions of kidney patients and driving disability in aging populations.

Originaltitel: Phosphate depletion in insulin-insensitive skeletal muscle drives AMPD activation and sarcopenia in chronic kidney disease