New protein compound shows promise blocking Alzheimer's disease mechanism

Researchers identified how a molecular chaperone called BRICHOS blocks the buildup of amyloid-beta, a protein linked to Alzheimer's disease. The finding could accelerate development of treatments that prevent neurodegeneration by stopping disease progression at its molecular roots—a shift that could reshape how drugmakers approach brain disease.

Originaltitel: Molecular Mechanisms of Amyloid-? Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone