Researchers find way to stop cancer-fighting cells from attacking each other

Scientists have identified a critical problem undermining a promising new cancer treatment: engineered immune cells designed to kill multiple myeloma tumors are instead destroying each other. A new study reveals how to prevent this self-sabotage by modifying the cells' surface properties, potentially unlocking a therapy that has shown early promise but faced significant hurdles in clinical development.

Originaltitel: Challenges in αCD38-chimeric antigen receptor (CAR)-expressing natural killer (NK) cell-based immunotherapy in multiple myeloma: Harnessing the CD38dim phenotype of cytokine-stimulated NK cells as a strategy to prevent fratricide