Old Drug Shows New Promise Against Cancer by Hijacking Protein Production

Researchers found that a metabolite of disulfiram, a decades-old alcohol addiction medication, kills cancer cells by disrupting how they make proteins. The discovery could open a new route for cancer treatment using an already-approved, inexpensive drug—potentially accelerating development and reducing costs for patients.

Originaltitel: Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET