Researchers Engineer Bacteria to Deliver COVID Vaccine Through Mucosal Route

Scientists modified a common probiotic bacterium to display coronavirus proteins on its surface, then used it to vaccinate mice through the nose and mouth. The approach triggered both systemic and local immune responses, potentially offering a simpler, needle-free alternative to injectable COVID vaccines that could improve global vaccination rates.

Originaltitel: Mucosal immunization with <i>lactiplantibacillus plantarum</i>-displaying recombinant SARS-CoV-2 epitopes on the surface induces humoral and mucosal immune responses in mice