Muscle disease mutations disable cell's waste-disposal system in different ways

Researchers found that different mutations in the desmin protein—which causes muscular dystrophy—break the cell's autophagy system through distinct mechanisms. The discovery suggests that one-size-fits-all drug approaches may fail, and personalized treatments targeting specific mutations could be necessary to restore muscle function.

Originaltitel: Desmin mutations impact the autophagy flux in C2C12 cell in mutation-specific manner