New pathway discovered in immune response to respiratory infections

Researchers have identified a previously unknown mechanism by which immune cells trigger inflammation in the airways in response to bacterial infection. The finding, involving a protein called TLR4 and a signaling molecule called IL-26, could lead to new approaches for treating severe respiratory infections or reducing excessive inflammation—a significant concern for companies developing immunotherapy drugs.

Originaltitel: TLR4-mediated release of heparin-binding protein in human airways: a co-stimulatory role for IL-26