New tool measures tiny particles in blood with unprecedented speed and detail
Researchers have developed a high-throughput profiler that can analyze nano-sized bioparticles—like exosomes and virus particles—far faster and more completely than existing methods. The advance could accelerate diagnostics for cancer, infectious disease, and other conditions by making it practical to screen patient samples at scale.
Originaltitel: High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler
<p>We introduce a method, single-particle profiler, that provides single-particle information on the content and biophysical properties of thousands of particles in the size range 5–200 nm. We use our single-particle profiler to measure the messenger RNA encapsulation efficiency of lipid nanoparticles, the viral binding efficiencies of different nanobodies, and the biophysical heterogeneity of liposomes, lipoproteins, exosomes and viruses.</p>