Two Protein Families May Work Together to Control Cell Inflammation
Researchers have identified potential direct interactions between two protein families that regulate chloride channels in cells—a discovery that could reshape drug development for inflammatory and pain conditions. The finding opens new therapeutic targets, particularly in cardiovascular disease, though scientists say much more testing is needed across other tissues.
Originaltitel: Ca <sup>2+</sup> ‐Activated Cl <sup>−</sup> Channels: Do Bestrophins and <scp>TMEM16A</scp> Interact?
AIM: -activated Cl- conductances. METHODS: In this review, we discuss the possibility that members of the two families, bestrophins and TMEM16A, may interact. RESULTS: independently of membrane potential, and both proteins are importantly associated with inflammation and pain transmission. However, it seems that little testing of a direct interaction of TMEM16A and bestrophins has been published. CONCLUSION: We conclude that there is evidence for direct interaction between TMEM16A and bestrophins in the cardiovascular system, and it will be important to determine whether similar interactions extend to other tissues.